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ω

• EPA

• EPA DHA

n-3 n-6α-

n-6 ω 6 γ γ

n-3 ω 3 α- EPA( ) DHA()

ω

2g×1 / 2g×2 / 0.6g×3 /

261.30/ 522.60/2 244.80/3

TG -10.9% -22.7% -11.3%

LDL-C -2.10% -1.08% -4.25%

HDL-C +2.44% +4.31% +1.64%

TC -2.71% -3.70% -4.25%

VLDL-C -10.2% -19.75% -8.42%

RLP-C -11.05% -20.61% -5.79%

sd-LDL -6.96% -16.21% +1.07%

Large-LDL +9.51% +16.37% +7.31%

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S600 EPADHA

DHA

NPC1L1 Niemann-Pick C1 like 1 ProteinLPL TG RLP

CoA HMG-CoA

TGTG VLDL

EPA/ DHA/

1 /930mg 750mg

2 /1800mg 1500mg

S600 3 /1800mg -

160mg/4 108mg/4

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VLDL LPL TG IDL RLPHTGL TG

LDL

RLP TG RLP

LDL Large LDL LDL HTGLTG sdLDL small dense LDL sdLDL

LDL LDL 2 5LDL

LDL

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HDL LPL RLP

A-1 ABCA1 ABCA1ABCG1 A-1 preβHDL preβH

DL (FC)(LCAT) (CE)

HDL3

HDL3 CE HDL2 HDL2HDL (SR-B1) TG

VLDL

HDL2 (CETP) VLDL LDL CETG TG HDL2 TG HDL2

HTGL preβHDL HDL3LDL

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1. CoATG

2. CoA βCoA TG

3. β TCA TG4. LPL VLDL

VLDL

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5. CETP VLDL LDL HDL TG CEVLDL LDL CE TG HDL CE TG LDL

LDL-C HDL-C HDL CE

EPA AA PGI3 PGI2TXA3

EPA PPARα PPARPPARα PPARγ

apoBDHA apoB VLDL

TG

NM HDL ABCA j-Tokyo

•

•

•

•

•

•

• ω3

•

•

• LDL

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>

10

20

1000

2M参照...

書き込み

2,160

or or

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nao tera

YouTube 109

30 5 22 30 3 31

or

H28.4.3

薬価・ジェネリックを検索

>>

>>

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本体 識別コードから医薬品名を検索

•◦

β

1 mL/min eGFR

2 CCr

80

( 1 170 cm( 2 50 kg

kg

>>

>>

>> ver.1.0β

>>

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Cre 1.4 mg/dl

計算する

CCr mL/mineGFR mL/min/1.73m2

m2

eGFR mL/min

• CCr eGFR

CCr30mL/min

15mL/min

eGFR90 or

60 8930 5915 29

15

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