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ONCOGÊNESE SÁBADO 14/03/2015 08:00 h CARCINOGÊNESE

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ONCOGEcircNESE

SAacuteBADO ndash 140320150800 h CARCINOGEcircNESE

A oncogecircnese ou carcinogecircnese eacute um fenocircmeno complexo multifaacutesico e dependente

de fenocircmenos geneacutetico e epigeneacuteticos que levam ao surgimento de ceacutelulas imortalizadas com crescimento autocircnomo com capacidade

de invasatildeo e metaacutestases

MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS

bull ANCORAGEMbull CEacuteLULAS MIGRADORASbull MECbull VASOSbull SIMETRIAbull PERIODICIDADEbull DIFUSAtildeO DE FCbull CEacuteL TRONCO bull CEacuteL SUPRESSORA

MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS

bull POR ALTERACcedilOtildeES DO DNA (MUTACcedilOtildeES)bull POR ALTERAR MECANISMOS DE CONTROLE DA EXPRESSAtildeO GEcircNICA

MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS

bull AUTONOMIA PROLIFERATIVAbull EVASAtildeO DE SINAIS INIBIDORES DE MITOSEbull EVASAtildeO DE APOPTOSEbull EVASAtildeO DE SENESCEcircNCIA REPLICATIVAbull AUTONOMIA DE SOBREVIVEcircNCIAbull INSTABILIDADE GENOcircMICAbull EVASAtildeO DO SISTEMA IMUNEbull INVASAtildeO E CARAacuteTER SUBSTITUTIVObull METAacuteSTASE

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull DA PROLIFERACcedilAtildeO CELULARbull DA DIFERENCIACcedilAtildeO CELULAR

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR

(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

ETAPAS DA CARCINOGEcircNESE

bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)

bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)

bull Progressatildeo (crescimento e metaacutestases)

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

A oncogecircnese ou carcinogecircnese eacute um fenocircmeno complexo multifaacutesico e dependente

de fenocircmenos geneacutetico e epigeneacuteticos que levam ao surgimento de ceacutelulas imortalizadas com crescimento autocircnomo com capacidade

de invasatildeo e metaacutestases

MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS

bull ANCORAGEMbull CEacuteLULAS MIGRADORASbull MECbull VASOSbull SIMETRIAbull PERIODICIDADEbull DIFUSAtildeO DE FCbull CEacuteL TRONCO bull CEacuteL SUPRESSORA

MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS

bull POR ALTERACcedilOtildeES DO DNA (MUTACcedilOtildeES)bull POR ALTERAR MECANISMOS DE CONTROLE DA EXPRESSAtildeO GEcircNICA

MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS

bull AUTONOMIA PROLIFERATIVAbull EVASAtildeO DE SINAIS INIBIDORES DE MITOSEbull EVASAtildeO DE APOPTOSEbull EVASAtildeO DE SENESCEcircNCIA REPLICATIVAbull AUTONOMIA DE SOBREVIVEcircNCIAbull INSTABILIDADE GENOcircMICAbull EVASAtildeO DO SISTEMA IMUNEbull INVASAtildeO E CARAacuteTER SUBSTITUTIVObull METAacuteSTASE

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull DA PROLIFERACcedilAtildeO CELULARbull DA DIFERENCIACcedilAtildeO CELULAR

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR

(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

ETAPAS DA CARCINOGEcircNESE

bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)

bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)

bull Progressatildeo (crescimento e metaacutestases)

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS

bull ANCORAGEMbull CEacuteLULAS MIGRADORASbull MECbull VASOSbull SIMETRIAbull PERIODICIDADEbull DIFUSAtildeO DE FCbull CEacuteL TRONCO bull CEacuteL SUPRESSORA

MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS

bull POR ALTERACcedilOtildeES DO DNA (MUTACcedilOtildeES)bull POR ALTERAR MECANISMOS DE CONTROLE DA EXPRESSAtildeO GEcircNICA

MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS

bull AUTONOMIA PROLIFERATIVAbull EVASAtildeO DE SINAIS INIBIDORES DE MITOSEbull EVASAtildeO DE APOPTOSEbull EVASAtildeO DE SENESCEcircNCIA REPLICATIVAbull AUTONOMIA DE SOBREVIVEcircNCIAbull INSTABILIDADE GENOcircMICAbull EVASAtildeO DO SISTEMA IMUNEbull INVASAtildeO E CARAacuteTER SUBSTITUTIVObull METAacuteSTASE

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull DA PROLIFERACcedilAtildeO CELULARbull DA DIFERENCIACcedilAtildeO CELULAR

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR

(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

ETAPAS DA CARCINOGEcircNESE

bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)

bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)

bull Progressatildeo (crescimento e metaacutestases)

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS

bull POR ALTERACcedilOtildeES DO DNA (MUTACcedilOtildeES)bull POR ALTERAR MECANISMOS DE CONTROLE DA EXPRESSAtildeO GEcircNICA

MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS

bull AUTONOMIA PROLIFERATIVAbull EVASAtildeO DE SINAIS INIBIDORES DE MITOSEbull EVASAtildeO DE APOPTOSEbull EVASAtildeO DE SENESCEcircNCIA REPLICATIVAbull AUTONOMIA DE SOBREVIVEcircNCIAbull INSTABILIDADE GENOcircMICAbull EVASAtildeO DO SISTEMA IMUNEbull INVASAtildeO E CARAacuteTER SUBSTITUTIVObull METAacuteSTASE

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull DA PROLIFERACcedilAtildeO CELULARbull DA DIFERENCIACcedilAtildeO CELULAR

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR

(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

ETAPAS DA CARCINOGEcircNESE

bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)

bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)

bull Progressatildeo (crescimento e metaacutestases)

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS

bull AUTONOMIA PROLIFERATIVAbull EVASAtildeO DE SINAIS INIBIDORES DE MITOSEbull EVASAtildeO DE APOPTOSEbull EVASAtildeO DE SENESCEcircNCIA REPLICATIVAbull AUTONOMIA DE SOBREVIVEcircNCIAbull INSTABILIDADE GENOcircMICAbull EVASAtildeO DO SISTEMA IMUNEbull INVASAtildeO E CARAacuteTER SUBSTITUTIVObull METAacuteSTASE

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull DA PROLIFERACcedilAtildeO CELULARbull DA DIFERENCIACcedilAtildeO CELULAR

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR

(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

ETAPAS DA CARCINOGEcircNESE

bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)

bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)

bull Progressatildeo (crescimento e metaacutestases)

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull DA PROLIFERACcedilAtildeO CELULARbull DA DIFERENCIACcedilAtildeO CELULAR

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR

(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

ETAPAS DA CARCINOGEcircNESE

bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)

bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)

bull Progressatildeo (crescimento e metaacutestases)

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR

(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

ETAPAS DA CARCINOGEcircNESE

bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)

bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)

bull Progressatildeo (crescimento e metaacutestases)

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

ETAPAS DA CARCINOGEcircNESE

bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)

bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)

bull Progressatildeo (crescimento e metaacutestases)

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

ETAPAS DA CARCINOGEcircNESE

bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)

bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)

bull Progressatildeo (crescimento e metaacutestases)

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

SUPRESSAtildeO DE CRESCIMENTO

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

ETAPAS DA CARCINOGEcircNESE

bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)

bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)

bull Progressatildeo (crescimento e metaacutestases)

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

ETAPAS DA CARCINOGEcircNESE

bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)

bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)

bull Progressatildeo (crescimento e metaacutestases)

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

ETAPAS DA CARCINOGEcircNESE

bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)

bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)

bull Progressatildeo (crescimento e metaacutestases)

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

ETAPAS DA CARCINOGEcircNESE

bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)

bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)

bull Progressatildeo (crescimento e metaacutestases)

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

VIAS DA CARCINOGEcircNESE

bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR

bull DEFEITOS NO SISTEMA DE REPARO DO DNA

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

TRANSDUTORES DE SINAIS

EFEITOS

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)

PELA INS DE ONCOGENES VIRAIS

ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA

PROTEINAS ANOcircMALAS

TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

HTLV-1

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

CARCINOGEcircNESE QUIacuteMICA

bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

CARCINOGEcircNESE POR RADIACcedilOtildeES

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

SUPRESSAtildeO DE CRESCIMENTO

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

PT LIGADORAS DE GTP

20 DOS CA HUMANOS

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

CARCINOGEcircNESE POR RADIACcedilAtildeO UV

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

CERATOSE ACTIacuteNICA

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

POacuteLIPOS ADENOMATOSOS

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]

Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13

Fearful Symmetry Subversion of Asymmetric Division in Cancer

Development and Progression

Bajaj J1 Zimdahl B1 Reya T2Author information

AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants

While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that

shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that

have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest

that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers

Cancer Res 75(5) 792-7 copy2015 AACR

copy2015 American Association for Cancer Research

PMID

25681272

[PubMed - as supplied by publisher]