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Uso Das Estatinas Na Doença de Alzheimer Uma Revisão
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17/02/2015 iAHInterfacedepesquisaLista
http://bases.bireme.br/cgibin/wxislind.exe/iah/online/ 1/1
BIREME/OPAS/OMSBibliotecaVirtualemSade
Basededados: LILACS
Pesquisa: 601299[Identificadornico]Totaldereferncias: 1
1/1Id: 601299 LILACSExpress
Autor: Silva,AnnelisaFarahdaGirardi,JosMarcosRaposo,NdiaResendeBarbosa.Ttulo: UsodasestatinasnadoenadeAlzheimer:umareviso/Statinsanditsusein
Alzheimerdisease:areviewFonte: HUrev36(3),jul.set.2010.
Idioma: pt.Resumo: ADoenadeAlzheimer(DA),caracterizadapelaperdadamemriaedepelomenos
outrafunocognitiva,setornoufocodeatenoporpartedospesquisadores,tendoemvistaoaumentodesuaprevalncianapopulaomundial.Apresenadasplacasneurticas,formadaspeloacmulodopeptdeobetaamilideedosemaranhadosneurofibrilaressoasprincipaisalteraesneuropatolgicascaractersticasdaDA.Estasalteraessoresponsveispeloprocessodeneurodegeneraoepelodesenvolvimentoprogressivodademncia.EstudosdemonstrammenorprevalnciaeriscoparaaDAemusurioscrnicosdeestatinas,frmacoshipocolesterolmicos.OobjetivodestarevisofoireunirpartedosestudosdaliteraturaqueprevilegiassearelaoentreasestatinaseaDA.Hindciosdequetaisfrmacospodemdesacelerarodeclniocognitivoereduziroritmoevolutivodadoena,atravsdeseusefeitospleiotrpicos,dasatuaesnafunoendotelial,dainibiodasntese?amilideedareduodoimpactodoemaranhadoneurofibrilar.Acreditasequehumaligaosignificativaentreoselevadosnveisdecolesterolnasclulasneuronais,ousodeestatinaseoprognsticodepacientescomaDA.(AU)
AlzheimersDisease(AD),whichischaracterizedbymemorylossandatleastanothercognitivedysfunction,becamefocusedbyresearchersduetoitsincreasingprevalenceinworldspopulation.Neuriticplaques,structuredbytheaccumulationofthepeptidebetaamyloidandtheneurofibrillarytanglesarethemainneuropathlogicalalterationsfoundinAD.Neurodegenerationandtheprogressivedevelopmentofdementiaareaconsequenceofthesealterations.Studiesobservedthatstatins(hypocholesterolemicdrugs)chronicusershavealowerprevalenceandadecreasedriskforAD.TheliteraturewasrevisedtargetingtherelationbetweenstatinsandAD.Thereisevidencethatthesedrugscandeacceleratethecognitivedeclineandreducethediseasesevolutiverhythmthrough:pleiotropiceffects,performanceconcerningendothelialfunction,inhibitionofbetaamyloidssynthesisandreductionofneurofibrillarytanglesimpact.Thus,thereisanoteworthyconnectionregardinghighcholesterollevelsintheneurons,statinuseandtheprognosisofpatientswithAD.(AU)
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