Transcript
Page 1: Revista Fármacos & Medicamentos (Edição 64)

!"#$%&'"()*+,-.'&%*+

!""#$%&'()%*(&

/"0$+1&23*

4&.&()$&5"56*().*1"5#&578&1$#&#"

9".%"$.$:&23*

!+,-./01234$5-$67/85-$59$67/4:3;35459$59$<95324+91/-=$>.-58/[email protected]$9$C97/97$67,92DE32-7$59$F2-.5-$2-+$G454$H-.+4$H4.+42I8/324

J9.91234+91/-$5-$G-1K923+91/-=$4$#-L4$6.4$9$-$#-L-$?974E3-$

!+,-./01234$5-7$6M23,391/97$,4.4$4$N84;35459$5-7$>.-58/-7$H4.+42I8/32-7$

#O+9.-$*P$)$F1-$Q!$)$R8/8:.-S#-L9+:.-S?9T9+:.-$59$U'%'

;(+)&1&2<"+5"5=.*>")*+5,&.'&%?8)$%*+=.*>")*+5"5;(+)&1&2<"+5,&.'&%?8)$%&+5@5A*182<"+5=&."()".&$+5#"54.&(#"+5B*18'"+

A"23*5"'5C"+)&D8"

6*E".)8.&5F+G"%$&1

=-0$(&5HI

Page 2: Revista Fármacos & Medicamentos (Edição 64)
Page 3: Revista Fármacos & Medicamentos (Edição 64)

! " # $ % & ' (!) * + , & % $ * - . ' ( ! " # # # $ % & % ' ( ) * + ) , -. ' ( ) * / - 0 -. ' ( ) # 1 2 3 2 # # # 4

E d i t o r i a l

!"#$%&&#&'!"#()*+,#&-'.&/%$+01+2034#'5%$%&&6"+0

! !"#$%"& %'#()*+%",& -"+./"!0(*%!"& 1"))"& 12+&*+"')-2+/"34$)& 5($&-"6$/& $72,(%+& 2)& 1+2.!$))2)& 1+2#(*%72)8& 9$.+"'#28& "))%/8& 1+2#(*2)&

"#$5("#2)& "2& !2')(/%#2+& -%'",:& ;)*"&<& (/"& #")& +"64$)& 1$,")& 5("%)& "& +$7%).*"& !"#$%&'(!)*+,&%$*-.'(& "=2+#"8& $/&)(")&)$34$)8&"))('*2)&+$9(,"*>+%2)8&#$7%#2&?&)("&%/12+*@'!%"&1"+"&2&"#$5("#2&-('.!%2'"/$'*2&#2)&1+2!$))2)&1+2#(*%72):&A& -"=+%!"3B2& #$& )2,(34$)& 1"+$'*$+"%)8&

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

1>).+$9%)*+28& 12+& /$%2& #2& $)*(#2& #$&$)*"=%,%#"#$8& <& 2(*+2& 1+2!$))2& 5($& -".72+$!$& "& $72,(3B2& #"& !"#$%"& %'#()*+%",&-"+/"!0(*%!":&V&$)*(#2&#$&$)*"=%,%#"#$&<&'$!$))O+%2&1"+"&/"'*$+&2&+$9%)*+2&#2&/$#%.

W2"&X$%*(+"Y

!"#$%&'()*+,(!"#$%&#'(#)&*)+",-*)./0%'#)#)1**"&#'/&*"/)230'%0*45&%(*"%/6)&/)"#7%$(/&!"#$%&'(!)*+,&%$*-.'(

!"/$'*2&1$+"'*$&2)&>+9B2)&+$9(,"*>+%2):&Z2'-2+/$&2&1+2!$))28&<&2&1+%'!%1",&$)*(#2&$C%9%#2&'"&+$'27"3B2&#$&+$9%)*+2&#$&(/&/$#%.!"/$'*2:&L2&"+*%92&#"&)$3B2&X$9%),"3B2&#$)*"&$#%3B2&[J&#"&!!)8&2&,$%*2+&12#$+O&!2'U$!$+&/"%)&"!$+!"&#2&$)*(#2&#$&$)*"=%,%#"#$&#$&,2'9"&#(+"3B2&#$&"!2+#2&!2/&2)&1"+@/$*+2)&#$-%'%#2)&'"&H$.)2,(3B2&'I&\8&#$&D]&#$&^(,U2&#$&DEEK&PH;&'I&\_DEEKR:A,</&#2)&"))('*2)&+$9(,"*>+%2)8&2(*+2&*$/"&$/&1"(*"&1"+"&

2)&1+2-%))%2'"%)&5($&"*("/&'")& %'#`)*+%")& -"+/"!0(*%!")&<&2&9$+$'!%"/$'*2&#2&!2'U$!%/$'*2:&;)*$&<&(/&!2'!$%*2&'272&1"+"&(/"&+$",%#"#$&'B2& *B2&+$!$'*$:&A&"1,%!"3B2&#$&'272)&$'-25($)&'2&/"+!2&#")&#%+$*+%6$)&#"&Q'*$+'"*%2'",&Z2'-$+$'!$&2'&a"+/2'%)"*%2'&PQZaR&$&#2&#2!(/$'*2&#"&b22#&"'#&c+(9&A#/%'%)*+"*%2'&PbcAR&.&WSb&#2&)<!(,2&ddQ&.8&+$1+$)$'*"&(/&'272&#$)"-%2&'2&!2'*+2,$&#")&"*%7%#"#$)&#"&%'#`)*+%"&-"+/".!0(*%!":&e2#"&/(#"'3"&#$)1$+*"&%'!2/1+$$')4$)&$&+$)%)*0'.!%")8&12#$'#2&)$+&"1,%!"#"&#$& -2+/"& %'"#$5("#":&V&"+*%92&#"&)$3B2&T"+"'*%"&$&Z2'*+2,$&#"&f(",%#"#$&"=2+#"&")&+"64$)&1$,")&5("%)&2&9$+$'!%"/$'*2&#2&!2'U$!%/$'*2&<&'$!$))O+%2&$&!2/2&"1,%!O.,2&#$&/"'$%+"&$-$*%7":f(",%-%!"+& 2)& -2+'$!$#2+$)& <& 2(*+"& $*"1"& %/1+$)!%'#g7$,&

$/&(/&1+2!$))2&1+2#(*%72:&L"&)$3B2&e$+!$%+%6"3B2&(/&"+.*%92&$'-2!"&2)&$C!%1%$'*$)&5($8&$/=2+"&)$/1+$&*$'U"/&)%#2&!2')%#$+"#2)&)(=)*@'!%")&%'$+*$)&$/&(/"&-2+/(,"3B2&-"+/".!0(*%!"8&1"))"+"/&"&"1+$)$'*"+&1"1$,&+$,$7"'*$&'2&#$)$/1$.'U2&#2)&/$#%!"/$'*2)8&#$7%#2&?&$72,(3B2&#2&!2'U$!%/$'*2&!%$'*g-%!2:&V& ,$%*2+&12#$+O&!2'!,(%+&5($&2&#$)$'72,7%/$'*2&#2&1+2#(*2&-"+/"!0(*%!28&",</&#2&$)*"=$,$!%/$'*2&#2&%')(./2&-"+/"!0(*%!2&"*%72&$&#"&#$-%'%3B2&#")&$*"1")&!+g*%!")&#2&1+2!$))28&"&#$*$+/%'"3B2&#"&5(",%#"#$&#2)&$C!%1%$'*$)&<&#$&-('#"/$'*",&%/12+*@'!%"&1"+"&"&5(",%#"#$&#2&1+2#(*2&-%'",:A,</&#%))28&'"& )$3B2&X$%"&'2&S2+*",&H"!%'$& Phhh:+"!%'$:

!2/:=+R8&"&[Ji&$#%3B2&#"&!!)&*+"6&2&+$)(/2&#$&(/&*+"=",U2&$,"=2+"#2&1$,2)&",('2)&#2&Z(+)2&#$&S>).T+"#("3B2& .&;)1$.!%",%6"3B2&S+2-%))%2'",%6"'*$&$/&A(#%*2+%"&b"+/"!0(*%!"&.&b2+./"3B2&#$&A(#%*2+$)&1"+"&"&Z"#$%"&Q'#()*+%",&b"+/"!0(*%!"&#2&Q')*%*(*2&H"!%'$8&'2&5(",&)B2&"1+$)$'*"#2)&2)&1+%'!%1"%)&%'#%.!"#2+$)&(*%,%6"#2)&1"+"&"&"7",%"3B2&#$&#$)$/1$'U2&#2)&21$.+"#2+$)&,29g)*%!2)&$&(/&/2#$,2&#$&08#0946%$(&1"+"&"(C%,%"+&'")&%')1$34$)&#$&"(#%*2+%")&#"&5(",%#"#$:&Z2/1,$*"'#2&"&$#%3B28&"&)$3B2&L"7$9($&*+"6&)(9$)*4$)&#$&$%(#$&)2=+$&1$)5(%)"&!,g'%!":

Page 4: Revista Fármacos & Medicamentos (Edição 64)

! ! " # $ % & ' (!) * + , & % $ * - . ' ( " ! # # # $ % & % ' ( ) * + ) , -. ' ( ) * / - 0 -. ' ( ) # 1 2 3 2 ! " # $ % & ' (!) * + , & % $ * - . ' ( " ! # # # $ % & % ' ( ) * + ) , -. ' ( ) * / - 0 -. ' ( ) # 1 2 3 2 # # # 4 5

S u m á r i o

!"#$%&'()*+,

!"

##

!#

$#

%%

&#

'#

'&

''

6)((-78)9:;9<=>7

?-@=7A>BC)

D78-<=>A#64EF

F97&>A>BG-7#-#4()H-&)7#I>(.><;%&=<)7

J>(>9&=>#-#6)9&()A-#:>#K%>A=:>:-

L-(<-=(=0>BC)

?-=>#9)#4)(&>A#M><=9-!"!###$%&'()*$'+,$-%

+>,-@%-

N)(9>A

!"#$%&'()*+,-$,./&0-$,-1,./&+2*3*-+-1,-1,41-*)+"1(&$5,6%$-0&$/,-1,718%+-+9:$,1,;1/&1/,./#1)<=*)$/,-1,>)$%-$,)$",?+-+,@$%"+,@+%"+)A0&*)+

6+B*3C:$,D%+/*31*%$,E,71/&+F01,(+,?6C!,G$%3-H*-1,I1+3*J+-+,1",6+%*/

6%$K1&$/,1,!(/&+3+9L1/,@+%"+)A0&*)+/,M,N$309L1/,6+%1(&1%+*/,-1,O%+(-1/,P$30"1/,

O1%1()*+"1(&$,-$,?$(C1)*"1(&$5,+,Q$B+,.%+,1,$,Q$B$,71/+=*$

!($B+9:$,(+/,P+)*(+/,-1,R/$,P1&1%*(S%*$

T#1%+-$%,U$8</&*)$,(+,?+-1*+,@+%"+)A0&*)+5,-+,>%"+J1(+81",+$,;%+(/#$%&1,-1,41-*)+"1(&$/

61/F0*/+,?3<(*)+

!!

"!

##

$!

Page 5: Revista Fármacos & Medicamentos (Edição 64)

! " # $ % & ' (!) * + , & % $ * - . ' ( ! " # # # $ % & % ' ( ) * + ) , -. ' ( ) * / - 0 -. ' ( ) # 1 2 3 2 # # # 4

56.7879&(:;<)

=-7)#5.'7-8&-

>.':?:@-.

A-(,7;)#6-#5&-867.-8&)#:)#B)89%.76)(#CA5BD

B).-(E7:?

F?:8-G:.-8&)H#F()@(:.:;<)#-#B)8&()?-#6-#F()6%;<)#CFFBFD

I-(J8E7:#-#/7(-&)(7:

KLE87E)9#-#K(:78--9

599%8&)9#M-@%?:&N(7)9

$O-(:E7)8:?

>PO-67;<)

A%O-(,79<)H#B))(6-8:;<)#-#BQ-R7:9

B)8&()?-#6:#S%:?76:6-#CBSD

F()6%;<)

T%(U67E)

5?.)P:(7R:6)

!"#$%&'()

>8@-8Q:(7:

*+,,-./01"'(

B).O(:9

F(-976J8E7:

I:(:8&7:#6:#S%:?76:6-

V7)&-E8)?)@7:

F-9W%79:#X#/-9-8,)?,7.-8&)#CFX/D

Y78:8;:9#-#B)8&:'7?76:6-

A-@%(:8;:#-#A:Z6-#$E%O:E7)8:?

/-O:(&:.-8&)#=L67E)[B7-8&UR7E)

M-E%(9)9#\%.:8)9#CM\D

])@U9&7E:

$'9-(,-H#-.#E:6:#:(&7@)H##:9#^(-:9#6-#B7(E%?:;<)H##E)8R)(.-#:#?-@-86:#:':7P)_

!"#$%&'#(#!!)

!"#$%&'(# )*(+*,-.&/,'#0'#1(*$/2#3%+#*4(%$%0&*05'#%6,%4,/'0*2#,(%$,/+%0&'7#",.4*05'#4'$/89%$#5%#2/5%(*08*:#'#4*4%2#5*$#%+4(%$*$#0*,/'0*/$#$%#+'5/)/,'.#*'#2'0;'#5'$#<2&/+'$#5%=#*0'$:#')%(%,%05'#.+*#;(*05%#'4'(&.0/5*5%#4*(*#'#5%$%03'23/+%0&'#5%# &%,0'2';/*#2',*2#%#,'+42%+%0&*05'#*#,'0&(/>./8?'#5*$#%+4(%$*$#+.2&/0*,/'0*/$7#@#(%3/$&*#!"#$%&'(!)*+,&%$*-.'(/4(%%0,A%#'#%$4*8'#5%#/0)'(+*B

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

&'(/*2#*$$%;.(*5*#4%2*#*+42*#2/>%(5*5%#5%#%64(%$$?'#5%#$%.$#*(&/,.2/$&*$:#>%+#,'+'#4'(#.+*#(%$4'0$D3%2#2/0A*#%F./2/>(*5*#%+#$.*$#'4/0/9%$7H$4%('#F.%#*#!!)#,'0&/0.%#*#')%(%,%(#*#'4'(&.0/5*5%#5%#*&.*2/=*8?'#

4*(*#&'5'$#'$#4(')/$$/'0*/$#5'#$%&'(#5%#)D(+*,'$#%#+%5/,*+%0&'$7I

:'(7-?# K:88%9# L# @(:6%:6)# -.# E7J8E7:9# -E)8`.7E:9#O-?:# Y:E%?6:6-# 6-# >E)8).7:# A<)# ]%70H# -9O-E7:?79&:#-.#2"#$%&'()# O-?:#\:(,:(6#V%978-99# AEQ))?# C>a5D#-#.:8:@-.-8&#O-?)#b=/#CA%U;:Dc#F)99%7#"d#:8)9#6-#-PO-(7J8E7:# E).)#O(-976-8&-H# 67(-&)(# -# @-(-8&-# -.#786Z9&(7:9#R:(.:EJ%&7E:9H#8:E7)8:79#-#.%?&78:E7)8:79H#8)#.-(E:6)#L&7E)H#$KB#-#Q)9O7&:?:(H#8)#V(:97?#-#8:#

5.L(7E:#]:&78:c#5&%)%#-.#-8&76:6-9#6-#E?:99-#6)# 9-&)(_#599)E7:;<)#V(:97?-7(:#6:#b86Z9&(7:#Y:(.:EJ%&7E:#C5VbY5M=5DH#A7867E:&)#6:#b86Z9&(7:#6-#F()6%&)9#Y:(.:EJ%&7E)9#8)#>9&:6)#6-#A<)#F:%?)#CAb+/aAY5M=5D#-#599)E7:;<)#6:#b86Z9&(7:#Y:(.:EJ%&7E:#6-#F-9W%79:#Cb+K>MY5M=5Dc#Y)7#.-.'()#6)#B)89-?Q)#6:#bYF=5#CI-8-'(:Dc#5&%:?.-8&-#78&-@(:#)#B).9:%6-#6:#Y-6-(:;<)#6:9#b86Z9&(7:9#6)#>9&:6)#6-#A<)#F:%?)#CYb>AFDc#e#R%86:6)(#-#,7E-[O(-976-8&-#6:#FQ:(.:?:&78:#B)89%?&78@H#-9O-E7:?70:6:#-.#E)89%?&)(7:#6-#@-9&<)#8)#9-&)(#6-#9:Z6-c

!$F>M

KK

!"#$%&'%(')*+,-'"./+'"'0&*,%#"

AA$

ABB

AB

A5B

M\

FM$/

FM>A

FFBF

FX/

=fK

=5

]$I

TaM

IS

I/bM

YB

>gF

>+I

>=V

/=B

BS

B$=F

B$=

VKB

5M>I

5]=

5/=

I:'(7-?#K:88%9H#R%86:6)(#-#,7E-[O(-976-8&-#6:#FQ:(.:?:&78:#B)89%?&78@

Page 6: Revista Fármacos & Medicamentos (Edição 64)
Page 7: Revista Fármacos & Medicamentos (Edição 64)
Page 8: Revista Fármacos & Medicamentos (Edição 64)
Page 9: Revista Fármacos & Medicamentos (Edição 64)
Page 10: Revista Fármacos & Medicamentos (Edição 64)

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % 3 " ! "

!"#$%&'&()*+$*+($,-.&*/$01&*+&,2-$%$*+%&3!"#$%&'!($)*#&+)%,&)'!-#&&.!/'+!0&12'+3!4#&#+56'7)+!89:;

!<)6&.!-.=/#!>$)?.73!@'&%'!>7#1&#!89-;!

!($)*#&+)/./#!A'&%#!/'!@.&.$,!8(AB@>9;3!C'$/&)$.!8@9;

45+%67&'(')*+,-+./0)*+,1/2/0)*+%8/%3"!"#$

C o r r e s p o n d ê n c i a s

!"#$%&'()'&*+,-$*)'.&'(/%'-0%'&%&%12/$2'&'23+%&2&#$'()1&%&2&*2"-%452&5)&+%#$'-)&!"#$%&'(!)*+,&%$*-.'(&6)+)&2&%78)$1&+%#$'-)9+)*$"%:*28:3+

4,2-&5,)*+*6$+)7-,-8)+*)9#&+$+#&2-*/$+!"#$%&'(!)*+,&%$*-.'(

>!&#*)+%.!!"#$%&'(!)*+,&%$*-.'(!8D--A!EFGHIEJHF;!K!L?.!6LM7)N.O2'!%&)?#+%&.7!/.!9"A!"'?#&N).7!#!P/)%'&.!C%/.Q3!/)&)1)/.!.!#?6&#+.+!#!6&'R)++)'$.)+!/.+!)$/=+%&).+!SLT?)N.3!R.&?.NUL%)N.!#!R.&?'SLT?)N.Q

9*/:;8/5(/A)7N#!V.&M'+.

1;*/(+*/:%<=/>'(;.+:>&$)*.7/'!W).+X.&N'!YL)$%2'9#$.%'!")$%&.-K&1)'!-7.$

?++*8/5@AB+%CD>5;>+E<8;(+*;@FA)7N#!V.&M'+.!I!"9ZI-@![QJG[

<8;(+*>$/&K!@'7)N.+%&'!I!X4M!\]QHH\

<8;(+*@E4::;:(/5(/%/%G+*5@F;:(@%H/:I+5:J./F^#77_!X'$%#)&'!I!X4M!GJQ\\H

4::;:(/5(/%CD>5;>+E<8;(+*;@F-.$/&.!>SL)$'!`Q!X'&#%%'!I!"9YIDa!G\]]J[E]

?+F@)+*@*@0%5/:(@%<8;AB+>L/&#_!X.&)#!-)1L#$.1.!-.)%'3!Z,M)'!CL)b!@#7)N#&3!:.)&!".7)c%'3!:'2'!CL)b!P7).+3!:'&/)!V'%#%3!C.L&'!WQ!X'&#%%'3!CL)+!C'6#b!X.&%)$#b3!9)N.&/'!:'$++'$!#!9'+#7)!V.%)+%.!V.&&#%'

9*+K/(+%L*JM;>+%/%<8;(+*@%8/%4*(/")$%d).!-L#$.1.

4::;5@('*@:%/%?+**/:I+58N5>;@:9L.!@./&#!"d)N'3![e!"P@!GfGGFIGEG!I!-2'[email protected]'!I!-@4#7gZ.ch!8EE;!eJHGIe\[[!PI?.)7h!&#*)+%.i&.N)$#QN'?QM&

9@*@%45'5>;@*4#7QgZ.ch!8EE;!eJHGIe\[[PI?.)7h!&#*)+%.i&.N)$#QN'?QM&

>&%)1'+!#!?.%K&).+!.++)$./.+!$2'!&#R7#%#?!$#N#++.&).?#$%#!.!'6)$)2'!/.!9"A!"'?#&N).7!#!P/)%'&.!C%/.Q

?*D8;(+%8/%M+(+O%%>&SL)*'!9.N)$#!!#!/)*L71.O2'Q

Page 11: Revista Fármacos & Medicamentos (Edição 64)
Page 12: Revista Fármacos & Medicamentos (Edição 64)

! !"#$%&'()*+",$%-$+().")/!&0)1(+%23$2-4)5"$(+)6-$+")57.2$"%)2(),-8(+) 6"+5"9:78$9(4) +-"%$;"2")-.8+-)(,)2$",)<)-)=)2-)(787>+()2-)?@A@4)-5)!"+$,4).")B+".C"4)"D+-,-.8(7)"()57.2()A<)-5D+-,",)>+",$%-$+",4)9(5)D-+,D-98$#",)2-)2-,-.#(%#$5-.8()2-).(#(,).-EF9$(,)-5).G#-%)$.8-+."9$(."%HI+E".$;"2()D-%")J,,(9$"C'()*+",$%-$+")2")0.2K,L

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`+$9(,)N!+FL_-.`+$9(,Q4)()!"#$%&'()*+",$%-$+()2$,Da,)2-)75")b+-")9(575)D"+")78$%$;"C'()2(,)-SD(,$8(+-,)-)2(,)2-5"$,)#$,$8".8-,)>+",$%-$+(,)M7-) 6(+"5)c)/!&0)D"+")D+(,D-98"+)(D(+87.$2"2-,)2-).-EF9$(,4)(6-+-9-.2()9(5D%-8")$.6+"L-,8+787+")2-),-+#$C(,HJ)/!&0)1(+%23$2-)`)75)2(,)5"$,) $5D(+8".L

8-,)-#-.8(,)57.2$"$,)2") $.2K,8+$") 6"+5"9:78$9"4)(6-+-9-.2()(D(+87.$2"2-,)D"+")9(5D+"2(+-,4)

6">+$9".8-,4) 6(+.-9-2(+-,)-)7,7b+$(,)D"+") 8+(9"+)$2`$",4)6(+5"+)"%$".C",)-)6";-+).-EF9$(,)9(5)5"$,)2-)?<)5$%)D+(6$,,$(."$,)2-,8")$.2K,8+$"H)R5)?@AA4)") 6-$+")"9(.8-9-+b)-5)B+".d67+84).")J%-5".&"4)-)")D+(5-,,")`)M7-)()!"#$%&'()*+",$%-$+() 8+"E").(#$2"2-,)-),7+D+-,",)D"+")()-#-.8(e)%(9"%$;"2().()f"%%)g)2()/(5D%-S()2-)RSD(,$CT-,)\-,,-)B+".d67+84)()!"#$%&'()*+",$%-$+(4)M7-),-+b)()K.$9()9(5)-,8-)9(.9-$8().-,8-)"5>$-.8-4)9(5)b+-")2-)h?g)5i4)6(+5"2()D(+)M7"8+()$%&",4)+-9->-+b)E+".2-,)-5D+-,",)9(5)-,8".2-,)2-)E+".2-)D(+8-H)!"+")5"$,)$.6(+5"CT-,),(>+-)()!"#$%&'()*+",$%-$+(4)9(.8"8-)")J*0OP0B0H)/(.6$+")"),-E7$+)(,)2-D($5-.8(,)2",)-5D+-,",)-)$.,8$87$CT-,)M7-),-)6$;-+"5)D+-,-.8-,H

!"#$%&"''()*%+*%,)-.*/!"#$%&'$()$!'*!+%%,-&*./,!0#*%&1$&#*!'*!2('3%)#&*!4*#5,6785&-*!$!'$!2(%75,%!4*#5*-97)&-,%!:+02;<242=!jX-,8")-2$C'()2()!"#$%&'()*+",$%-$+().")/!&0)$.(#"5(,)-5)57$8(,)",D-98(,4)9(5)()"7SG%$()2",) -.8$2"2-,) 2-) 9%",,-) -) 9(5)",) -5D+-,",)M7-) +-D+-,-.8"5) +-"%5-.8-) ") 9"D"9$8"C'()>+",$%-$+").")b+-")6"+5(M7G5$9")-)6"+5"9:78$9"H)J) -SD-98"8$#") `) M7-) () *+",$%) ,-) 8(+.-) 75)D"+9-$+()E%(>"%).(,)D+FS$5(,)".(,H)X()!"#$%&'()*+",$%-$+(4)+-9->-5(,)#$,$8".8-,)-,8+".E-$+(,)-)8-5(,)M7-)"9(%&:L%(,)>-54)`)$,,()M7-)-,D-+"L

E s p e c i a l C P h I P a r i s - F r a n ç a

> ? ! " # $ % & ' (!) * + , & % $ * - . ' ( @ A ! ! ! B 7 ) 7 C # , D E , F $5 C # , D G $ H $5 C # , ! ? I > I

!"#$%&'()*+",$%-$+().)/-,0"12-)3")4!&5)6(+%78$7-)9-"%$:"7")-;)!"+$,)

Page 13: Revista Fármacos & Medicamentos (Edição 64)

!"# $%# &'(!)*+# ,-#-()!# $"# .-(# $/0($(#1('2)0)1(3$%# $(# 4")'(5# %!# 6)!)2(32"!# !7%#'"0"8)$%!#3%#9(6)*:7%#&'(!)*")'%#$"#.-(#-(3")'(# (8"'2(5# 0%34);6"*# "# 0(')3:%!(5#1%'2(32%#0.-1')-%!#(#3%!!(#-)!!7%+<

!"#$#%&'#$())#*&!"#$%&#'(#)&*)+",-.#'/"%01$)=># 9'?@A"3/')0%!5# "B)!2"32"# :;# $"C#

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

+,#-$.&/-%0)1*&$2!#"%'(#'&#'(#)&*)3"#*)&#)!4*'#5*6#'(1)&*)7%'*'0%*&1"*)&#)8$(2(1$)#)+"15#(1$)97:;8+<=>#SIQ,9#/#.-(#"-1'"!(#1P8*)0(#6)3@

0.*($(# (%#T)3)!2/')%# $(#H)O30)(# "# U"0@3%*%F)(#E."#1%!!.)#(#-)!!7%#$"#4)3(30)('#(# 1"!E.)!(# 0)"32)4)0(# "# 2"03%*?F)0(5# %#

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

=%$>1)?#"*4)&1)+*@%4A>1)B"*$%4#%"1

84%*'#)B*A"2(AC)&*)7:;8+

D?*"%)+*0A#01C)&1)E"%$(34%*

Page 14: Revista Fármacos & Medicamentos (Edição 64)

!"#$%$"&'#%'&()*#+%',(-'"'.(/!%+"'#"$%'0*('(.1/(&%'(&$2'1%/$3!31%#+"4'('%&&3.'%'(.1/(&%',%3'&('!"#&"53+%#+"67

!"#$%"&'()*(+,-.&!"#$#%&'%&#()*+),#-+'%&#%#.+/&'.0%(1)-'.%#%(*'2*),).%3-+#2*)&'*#.%&)%4*#)%&#%(1)-#5),#-+'%&)%6789:89':1;<'='*.%'3.1"/$%#$('"1"/$*#3+%+('+('

$/(3#%.(#$"'$%.>=.'1%/%'"&'$=!#3!"&'+%'?<@AB76

/0()$&1(2,"2-.%(*#.3&#-+#%&'%;)<'*)+=*3'%>*3.+413)8C'D%>"/%$E/3"':/3&$253%'3#3!3"*'&*%&'%$3,3+%+(&'

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

:/3&$253%'='*.%' 3#+P&$/3%'#%!3"#%5'0*('(#K(/)%'"'O/%&35'!"."'*.'B%N&'+"'1/(&(#$(4'*.'1/(&(#$('0*('1/(!3&%'&(/'F(3$"'('/(F(3$"'$"+"'+3%67

3()24%&5-(+,"$)-&')46.%&3*#+'*?(*#.3&#-+#%&)%8'*+#!%@/A,3!)89'@"/$(!'S*N.3!%' !".15($%' TU' %#"&' (.'

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

7$2()8-&'-"+,-.%2#*#-+#%!',#*!3)1%&)%6'*,31%()*)%)%B,C*3!)%;)+3-)%89''1%/$3!31%HI"'+%'?"/.35'S*N.3!%'#%':B;<'

='1/3#!31%5.(#$('F"!%+%'#"&'!53(#$(&'0*('1"&&*3'#"'O/%&354'/(%53-%#+"'*.'$/%>%5;"'3#&$3$*!3"#%5'(' $%.>=.'>*&!%#+"'1%/!(3/"&'#"&'1%N&(&'+%'9.=/3!%' D%$3#%' ('#"&'+(.%3&' 1%N&(&' 1%/%'"&'0*%3&'%'?"/.35'(&$2';%>353$%+%'%'!".(/!3%53-%/'&(*&'1/"+*$"&6'C'#()E!3"'+%'(.1/(&%'&('>%&(3%'#%'&N#$(&('+('.%$=/3%'0*N.3!%'F%/.%!G*$3!%'('!".(/!3%53-%."&'(&&(&'3$(#&'!".'%&'1/3#!31%3&'(.1/(&%&6'91/(&(#$%."&'#%':B;<'+*%&' 2/(%&'+(' %$*%HI"' +%' (.1/(&%4' 0*(' =' %' 1%/$(' +('.%$=/3%&M1/3.%&'('%'1%/$(',($(/3#2/3%6'9'1%/$(',($(/3#2/3%'%'?"/.35'$/%>%5;%'!".'"*$/"'."+(5"'0*('='"'1/"+*$"' $(/.3#%+"'(' $%.>=.'>*&!%'+(&(#,"5,(/' 1%/!(/3%' #"&' 1%N&(&' +%'9.=/3!%'D%$3#%'('"*$/"&'1%N&(&6'9'1/(&(#H%'#"'B%,35;I"'O/%&35(3/"'='.*3$"'3.1"/$%#$(4'1"3&'/(P#('$"+%&'%&'(.1/(&%&4'!/3%#+"'*.'>5"!"'0*('%$/%3'&3)M#3F3!%$3,%.(#$('"&'1%/$3!31%#$(&'+%'F(3/%'('!/3%'*.'3#$(/(&&('!%+%',(-'.%3"/'&">/('0*(.'&I"'"&'1/"+*$"/(&'('"'0*('(5(&'(&$I"' F%-(#+"'#"'O/%&356'C&'%&32$3!"&'$(.'&('3#$(/(&&%+"'>%&$%#$(4'%&&3.'!"."'(.1/(&2/3"&'+('"*$/"&'1%N&(&'!"."'</I4'R/=!3%'('XN/3%6'9'?"/.35' /(%53-%'(&&(' $31"'+(' $/%>%5;"'+(#$/"'+"'O/%&354'1/3#!31%5.(#$(4'#%&')/%#+(&'(.1/(&%&'+(')(#=/3!"&'('#%&' 3#M$(/#%!3"#%3&6' [' *.'."+(5"' +(' #()E!3"' 0*('"1(/%."&'(',(#+(."&'1%/%'"*$/"&'!53(#$(&'+%'9.=/3!%'D%$3#%6'C'/(&*5$%+"'$(.'&3+"'>%&$%#$('1"&3$3,"6'9':B;<'='>%&$%#$('1/"+*$3,%67'

7-9"):%-#&1":)4#0()-.&2#*#-+#%!',#*!3)1&)%D3E3.F'%>4(./1).%&)%G#-3H%G1'<)1

I'F'%J*).,'-+)-'0%&'%K3'1=+/.

L&3-3*%63-'++30%&)%:*=%G#-C*3!'.

B/2/.+'%G#*)1&3

>"*3.+3)-'%J*'++)0%&)%8M!',#&

K#)+#%N1#3,%#%O/<#,%P3-)*&3

E s p e c i a l C P h I P a r i s - F r a n ç a

Page 15: Revista Fármacos & Medicamentos (Edição 64)

!"#!"#$%&###$%&'(&$)*#')#+,-.#/0%*12&13#4#)#35$0%6)7809#:6;)*<3'63#)#=3'&5#35$0%6)#(>$?;*)?#@3*)6&'0?)?#1;%)?#$)%)# 601)#)#:<4%&()#A)6&')B#<)?#(0<#)#1;$*&()780#1)#C>D%&()#3<#:'>$0*&?#0?#'3@E(&0?#3<#F<D&60#<;'1&)*#)G)'7)%80#<;&609#H3%3<0?#;<#35(313'63#13#$%01;780#G&?)'10#)#35$0%6)780#$)%)#)#I;%0$)#3#0;6%0?#<3%()10?#(0<0#)#JC%&()#10#K;*B#0#.%8#3#)#H;%L;&)9#"#M%)?&*#63<#?&10#G&?60#(0<0#;<#,)N?#3<#L;3#->#13<)'1)#3#6)<D4<#0'13#->#$%01;60?#13#L;)*&1)139#:#=3'&5#4#;<)#3<$%3?)#OPPQ#')(&0')*#L;3#0$3%)#(0<#63('0*0@&)#&'63%')(&0')*B#(3%6&C&()1)#$3*)#:RS.K:B#0;#?3T)B#3?6>#-)D&*&6)1)#)#G3'13%#<;'1&)*<3'639U

!"#$%&"'()*"%+()(,)-.%!"#$%&#'!$'(&)&*'($+,-"&*'!.'/"&0.1'!:#M&0*)D#$)%6&(&$)#1)#+,-.#/0%*12&13#(0<#)#

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

/-0)-%1"2(#.%+$#$(%$'!$'$23&#%.45&'!.'/"&0.1!Z0;G3#<)&?#$%0(;%)#$0%#$)%(3%&)#$)%)#35$0%V

6)780#10#L;3#'0?#0;6%0?#)'0?9#:#M&0*)D#)$%3?3'6)#$%01;60?#&'0G)10%3?#3#()1)#G3W#<)&?#?3#&'?3%3#'0#<3%()10#&'63%')(&0')*B#0C3%3(3'10#'0G&1)13?9#.?60#(-)<)#)#)63'780#13#$063'(&)&?#$)%(3&%0?#3;%0$3;?#3#13#0;6%)?#%3@&[3?#10#<;'10B#(0<0#0?#I<&%)10?#J%)D3?B#L;3#6)<D4<#$)%6&(&$)<#1)#+,-.9U

!"3"%4)-#2"5*-5".'!"#$%&#'!.'/"&0&%6*'!&'/#.*"0!:#M&0*06;?#10#M%)?&*#131&()V?3#)#*&(3'(&)<3'60#

3#\#35$0%6)780#13#$%01;60?#C)%<)(Y;6&(0?#$)%)#0?#<3%()10?#1)#:<4%&()#A)6&')B#1)#JC%&()#3#10#"%&3'63#]41&09#:64#-0T3B#0?#$%01;60?#3%)<#35V(*;?&G)<3'63#$%01;W&10?#')#+-&')B#')#K;4(&)B#')#K;N7)#3#3<#,0%6;@)*#3B#)@0%)B#&%3<0?#$%01;W&%#'0#M%)?&*B#C)G0%3(3'10#)#35$0%6)780#$)%)#)#:<4%&()#A)6&')9#"#,)G&*-80#M%)?&*3&%0B#$0%#?;)#1&<3'?80#13'6%0#1)#C3&%)B#)6%)&#<;&6)?#$3??0)?9#:#3<$%3?)#)$%0G3&6)%>#)#+,-.#$)%)#C3(-)%#G>%&0?#)(0%10?#$)%)#35$0%6)7809#^#;<#$0'60#13#$)%6&1)9U

6(7#"5%+(7(8),5,.%.**$**&#'!$'(&)&*'($+,-"&*'!.'76#&8.#9.#!:#+,-.#4#;<#3G3'60#3?$3(&)*9#:#I;%0C)%<)#

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`Q#10?#(0'6)60?#6%)'?C0%<3<V?3#3<#'3@E(&0?9#:#I;%0C)%<)#(0<$%0;#3<$%3?)?#')#:%@3'6&')#3#'0#a%;@;)&#3#$%0?$3(6)#(0<$%)%#0;6%)?#3<$%3?)?#3<#0;6%0?#$)N?3?9#:?#)L;&?&7[3?#&'&(&)%)<V?3#3<#bPPc#3#0#0DT36&G0#4#)63'13%#)# 601)#)#:<4%&()#A)6&')#3#)#:<4%&()#10#K;*9#a6&*&W)<0?#)#3?6%;6;%)#1)#3<$%3?)#3#C;6;%)<3'63#6)*G3W#(0'(3'6%3<0?#)#$%01;780B#<)?#)#&14&)#4#?3<$%3#;6&*&W)%#)#3?6%;6;%)#*0()*9U#

:60"&';.(.<.='!.'>$("2

?@9&($'A(!#.!$='!&'B$!0$@

C&1$#*&('D$%#6(+.#&='!.'>$("2

B.#-&':#='!.'DE.#9.1'$'?E$<E.#'FE.(!$='!.'?6('

A(.'D.60.'/#.(-&='G.6#.'>&9$*'$':.(!"#.'D$#$"#.='!.'/"&0.1

H.0$(%"(.'/."+&##".='!.'I"('B.*%$#

:&*J'K&##$".'!.'?"0).='!.'A/LMNLOL

Page 16: Revista Fármacos & Medicamentos (Edição 64)

!"#$%&'"("(%)%*!"#$%&'$()$!'*!+*,-$".*#/*!"#$%&'()*%+,%# -# ',%# (,.+(/%#!"#$%&'#

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

+#,-.&/%(%0"1.*!'&#$)0#*!'*!1,*()*!'*!20$.#&(3$#!4(3$,.$&/!'$!4)*1$5$#&5*!'*!6$##*!76"8!"#I7(*+14N(+# B4N(&*(1,#5(17#.%+%#7#)%51F

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

23435)%&6.1$#73.&8.$",9#*!3$#$()$!'$!($395&0%!&('-%)#&*&%!'*!20$.#&(3$#!4(3$,.$&/!"#I7(*+14N(+# B4N(&*(1,#(/6<# 07,.&(6%427#

SZ[#%47/#2(#(O1/69401%# (,#4M5(&# N&7J%&# (#47#

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`"^$B@"a:#)%+%#(/6%/#47F5%/#(,.+(/%/#-#',%#N+%42(#7.7+6'412%2(#2(#N%4*%+(,# 6(,.7#2(# 1,.&(,(46%=>7#2(#',%#.&%46%#47#I+%/1&:!

:"$#"&;#,<#"&=$)#>&?"("$4%*!3$#$()$!'$!/*#5*%!$!1*)$()$%!'*!:$',$;!R#7J?(6157#27#b(2&(c#4%#K)*B#d7+&2e12(#

-# .+7/.(06%+# 4(NY017/:# GO.%421+(,7/;# 47/#.+YO1,7/#,(/(/;#%#(O.7+6%=>7#.%+%#7/#.%M/(/#2%#",-+10%#f%614%:#^%#K)*B#51/16%,7/# 87+4(F0(27+(/;#074*(0(,7/#.7+618Y&17/#(#5(+1810%,7/#%#270',(46%=>7#4(0(//<+1%#.%+%#%#<+(%#+(N'F&%6Y+1%:#R#)%51&*>7#I+%/1&(1+7;# &70%&13%27#4%#<+(%#0(46+%&#2%#8(1+%;#-#1,.7+6%46(#.71/#7#)%M/#515(#',%#/16'%=>7#(074g,10%#.+151&(N1%2%#(#*<#07421=h(/#2(#%6(42(+#%#5<+17/#7'6+7/#,(+0%27/:Q#

;#(%1.&@$5#1#&9.&219$"9.*!3$#$()$!'$!(0<0%!($395&0%!'*!:$',$;!R#b(2&(c#(/6<#J(,#.7/10174%27#47#,(+0%27#

J+%/1&(1+7#(,#6(+,7/#2(#N(4-+107/#(#J'/0%;#4%#K)*B;#4757/#.+72'67/;#4>7#%.(4%/#(,#N(4-+1F07/#(#.+72'67/#.%+%#07,.&(,(46%+#7#.7+618Y&17#2%#(,.+(/%;#,%/#6%,J-,#.+72'67/#E'(#%142%#4>7#/>7#07,(+01%&13%27/#47#,(+0%27#J+%/1&(1+7;#E'(# /(# (40%1O(,#4%/# &(N1/&%=>7#2%#"^$B@":#G,.+(/%/#(/6+%4N(1+%/#(/6>7#J'/0%427#(,.+(F/%/#47#I+%/1&#.%+%#%&70%+(,#/('/#.+72'67/;#(#7#)%51&*>7#I+%/1&(1+7#4%#K)*B#-#',%#.746(#(46+(#(//%/#(,.+(/%/:Q##

AB,#%&23435)%&:"C"#$"*&1#$%&'$()$!'*!=*>0#<&'*!"#.%+6101.%=>7#2%#f%J7+512%#4%#K)*B#-# 1,F

.7+6%46(#(#7#7J?(6157#-#J'/0%+#146(+,(21<+17/#2(#/M46(/(#E'M,10%#.%+%#%#.+72'=>7#2(#,(210%,(4F67/#5(+610%&13%27/;#(O%6%,(46(#.%+%# &(5%+#(//(/#

?&5*#'0!@0$,.0A!'*!B0#/&,!C-D/&5*

=-&E!FGH<&,*A!'*!IB?J

J*&#0!K*/*/0)0A!'*!+*,-$".*#/*

J0%L!?0>$#)0!"$#$&#*A!'*!2&0,*>

:*#&($)$!:&(&$#0!$!:*#5$,*!6**'

E s p e c i a l C P h I P a r i s - F r a n ç a

Page 17: Revista Fármacos & Medicamentos (Edição 64)

!"#$%&$'!(%!)*+,-%-+)+.%-*!/0+1+2-3!/45)+.%-*!/$!%)+6+&7!#)+ !&,)%#-"#$+,)%+8)"9%$9-%+-*+ !"':*#%!-*+;-%&)<7=&!8-*+$+ ;-%&-8>7#!8-*+<7$+,%$#$"'$&+*$+ !"*$%!%+"$**$+&$%8-')+&7"'!-/0+?)"#-%+7&+$*#-"'$+,%@,%!)+6+&-!*+8)&,/$A)B+,)%6&+$&+7&+2-3!/45)+6+&7!#)+&-!*+*!&,/$*+$+&-!*+!"#$%$**-"#$0+C7-"#)+D*+,$%*,$8#!3-*+'$+$A,)%#-E5)B+-+&-!)%!-+'-*+$&,%$*-*+,$"*-&+$&+,)**7!%+<7-/!'-'$+,-%-+$A,)%#-%+,-%-+&$%8-')*+%$97/-')*+$+"5)+$A,)%#-%+,-%-+&$%8-')*+'$+F-!A-+<7-/!'-'$B+,)%#-"#)+-+!"G#$"E5)+'-+H-F)%3!'-+6+'$*$"3)/3$%+,%)'7#)*+8)&+-+$*#-F!/!'-'$+$+-+<7-/!'-'$+"$8$**(%!-*+,-%-B+7&+'!-B+$A,)%#-%+,-%-+&$%8-')*+%$97/-')*0I+

!"#$%&'()*+)#,,#-!"#$%&'$()$%*#"%+&%!",!-,.%+,JK+L-/$"-+#%-F-/4-+8)&+!&,)%#-E5)B+'!*#%!F7!E5)+

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

.%/0'!123++3'4#56#-')$%*#"%+&%!",!/**'0#,12'!3$,*#.%#$,!"%!4%5%+"%"'$%*!%!67)'$&,"'$%*!"%!6+*87'*!9,$7,0:8&#0'*!;/3469/4<J1+8)"#-#)+$;$#7-')+"-+O24P+6+)+&-!)%+F$G

"$;=8!)+ $+ -+&-!)%+ %$-/!Y-E5)+<7$+ $A!*#$+ ,-%-+)*+ !&,)%#-')%$*+F%-*!/$!%)*+$+)*+-**)8!-')*+'-+K.ZPUKZ0+K8%$'!#)+$&+7&-+;$!%-+'$+"$9@8!)*+$+")*+8)"#-#)*+$;$#7-')*0+K+O24P+6+7&+F)&+;@%7&+'$+'!*87**5)+ #-&F6&+$&+ %$/-E5)+-)+-*,$8#)+#68"!8)0+K+!&,/$&$"#-E5)+'$+%$9!*#%)+")+.%-*!/+6+7&+')*+,)"#)*+'$+&-!)%+'!*87**5)+"$**$+$3$"#)+$+6+7&-+,%$)87,-E5)+'$*#-8-'-+!"8/7*!3$+,$/)*+!"3$*#!')%$*+$*#%-"9$!%)*0I

73+2#&+3$8/'93$,3/-!)$%*#"%+&%!",!=,+>,!?@,$7,JK+O24P+6+7&+')*+$3$"#)*+&-!*+;)8-')*+"-+!"G

':*#%!-+;-%&-8>7#!8-+$+-+,-%#!8!,-E5)+'-*+$&,%$*-*+F%-*!/$!%-*+6+8-'-+3$Y+&-!*+-#!3-0+K8%$'!#-G*$+")+8%$*8!&$"#)+')+&$%8-')+ ;-%&-8>7#!8)+,-%-+)*+,%@A!&)*+-")*0+K*+,$%*,$8#!3-*+ *5)+,)*!#!3-*0+1+,$%;!/+'-*+$&,%$*-*+$A,)*!#)%-*+$*#(+8-'-+3$Y+&$/4)%B+*5)+$&,%$*-*+'$+-/#-+#$8")/)9!-B+#)'-*+$A#%$&-&$"#$+!&,)%#-"#$*+,-%-+)+")**)+"$9@8!)0I

:3&;%'!$,%$)%'<#+;5)%&-!)$%*#"%+&%!",!?@,$7,AJ1+)FS$#!3)+ '$+ ,-%#!8!,-%+ '-+O24P+ 6+ $*#-%+

S7"#)+D*+%$,%$*$"#-'-*B+)%!$"#-"')+8/!$"#$*+"-*+3!*!#-*+$+ #$"#-"')+'$*8)F%!%+,%)'7#)*+")3)*B+3-/)%!Y-"')+-*+,-%8$%!-*+<7$+,)**7=&)*B+)+<7$+6+!&,)%#-"#$+"-*+%$,%$*$"#-E[$*0+\(+VN+-")*+%$,%$*$"#-&)*+ -*+ $&,%$*-*+ ")+.%-*!/+ $+ !*#)+6+&7!#)+ !&,)%#-"#$+ ,-%-+ 8)"*)/!'-%+&-!*+ )*+8)"#-#)*0+1+2-3!/45)+.%-*!/$!%)+$*#(+&-!)%+')+<7$+$&+)7#%-*+$'!E[$*+$+6+,%-Y$%)*)+3$%!;!8-%+<7$+)+.%-*!/+$*#(+8%$*8$"')+8)&)+$A,)%#-')%0+1+2-3!/45)+.%-*!/$!%)+6+7&+/)8-/+'$+$"8)"#%)+$"#%$+ ,-%8$!%)*+ $+ $*,$%)+ <7$+ 8%$*E-+ -!"'-+

BC.5#,!D,7,$E'F!"'!G%".%H

/A",..,!I%@7%F!",!/3469/4

I%.*'+!?%.%E$#+#F!",!J8$'K,$7,

L,+"%$.,+>*!M,+&,*F!",!=,+>,!?@,$7,

/+"$N,!%!9%$+,+",!G,$O8%*!?#+&'F!G,$,+,&,!%!B%$,K#7

G,$0'!P8#+&2'F!I#.0%!Q'7'R,+%!%!B%$,K#7!3$,+0'!I%&'

Page 18: Revista Fármacos & Medicamentos (Edição 64)

!"#$%&%'(&%)"*"%!"#$%&!+,&$"$%-,"$#.&#,"$%/0.1"23"$% +","% &4+0,1"560% &% +,0$+&7560%80%!&,7"30%#81&,8"7#08".9:

!"#$%&'()*+,"%-),."#%/),01,2%!"#$%&&#"'(#')*"&#'(%'$+",-).+'%')##"(%/+(#"'(#'0+1#"+23".#'4/+562.)#'(%'7/&*,#&'8+",+)9*2.)#':0478;'(+'<#/2.$6).+'=/.>%"&.(+(%'?+235.)+'(#'@.#'A"+/(%'(#'B*5':<=?C@B;;<%=>?@%$(,A#(%&!%(!%&$B0,50%708*(810%&81,&%

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

&03)$(%4()567#2'D%"%/2%'(%'8()17.,09'(+'=/.E#'F*6,.)+'8+",+)9*2.)+;>%L8#60%K(V!#7"% @",!"7P(1#7"% +",1#7#+"% 3"%

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

7/(G&2".+&'8+",#H*6,.)+'%'8+",+)9*2.)+'I"+&.5%."+&J'K%&2+H*%'/#'?%/-".#'7/2%"/+).#/+5>%&4&!+.0%3&%"80$%"81&,#0,&$G%0%N"/#.)60%J,"$#.&#,0G%70!2

+0$10%+0,%&!+,&$"$%B",!0'(V!#7"$%&%B",!"7P(1#7"$%%#8$1"2."3"$%80%J,"$#.G%/&!%$&%$(+&,"830%80%'(&$#10%'("81#3"3&%&%'(".#3"3&G%"1,"#830%"$$#!%103"$%"$%"1&85R&$%30%!&,7"30%#81&,8"7#08".%8"%MN)?%X0,.3Y#3&%Z[\[G%&$1&%"80%,&".#U"3"%&!%N",#$G%@,"85"9]$1&%&/&810G%'(&%D%708$#3&,"30%0%!"#0,%30%!(830%80%

$&10,G%,&".#U"30%"8(".!&81&%8"%](,0+"G%D%)0*&%(!"%#!+0,21"81&%/#1,#8&%+","%"%#83F$1,#"%-,"$#.&#,"%&%"%+",1#7#+"560%3"$%&!+,&$"$%3&/&,S%,&B.&1#,%,&$(.1"30$%708$#3&,S/&#$%8"%-"."85"%70!&,7#".%30%$&10,G%+0#$%)0(/&%"%+",1#7#+"560%3&%!"#$%3&%\9^[[%&4+0$#10,&$%&%(!"%!D3#"%"7#!"%3&%Z_%!#.%/#$#1"81&$G%0%'(&%3&!08$1,"%"%#!+0,1W87#"%&%"-,"8AP87#"%!(83#".9]!%Z[\[G%)0(/&%+",1#7#+"560%,&70,3&%3&%&4+0$#10,&$%&%3&%

/#$#1"81&$%-,"$#.&#,0$G%&%&!%(!"%S,&"%-"$1"81&%+,#/#.&A#"3"%&%3&%A,"83&%/#$#-#.#3"3&%+","%0$%/#$#1"81&$G%0%'(&%7&,1"!&81&%A&,0(%#8F!&,"$%0+0,1(8#3"3&$%3&%8&AQ7#0$9]!%(!"%&4+&,#P87#"%#80/"30,"G%".D!%3"%"$$&$$0,#"%3&%

+,0B#$$#08"#$%-#.V8AO&$G%$"."$%,&$&,/"3"$%+","%,&(8#R&$G%!"#$%&"$#G%#!+,&$$0,"$%&%0(1,0$%$&,/#50$G%&%0%1,"3#7#08".%7"B&U#8)0%-,"$#.&#,0G%0%N"/#.)60%J,"$#.&#,0%70810(%70!%(!"%3#$+0$#560%3&%&$1"83&$%!03&,80$%&%3&%BS7#.%/#$(".#U"560G%&%70!%(!"%S,&"%70!(!%+","%(1#.#U"560%30$%&4+0$#10,&$%'(&%B0#%7&8S,#0%3&%3#/&,$0$%&87081,0$%&%0+0,1(8#3"3&$%3&%8&AQ7#0$9%

L'H*%'!#(%C&%'%&!%"+"'!+"+'MNOOP'%,'8"+/Q$*"2RM0!%0%"+0#0%3"%>AP87#"%J,"$#.&#,"%3&%N,0!0560%3&%

]4+0,1"5R&$%&%?8/&$1#!&810$%`>N]a2J,"$#.bG%3"%@#8"87#"230,"%3&%]$1(30$%&%N,0*&10$%`@?H]NbG%"%+",1#7#+"560%3"%>AP87#"%H"7#08".%3&%I#A#.W87#"%E"8#1S,#"%`>HI?E>b%&%0%,&$+".30%3"$%&81#3"3&$%,&+,&$&81"1#/"$%30%$&10,%#83($1,#".%-,"$#.&#,0c%>$$07#"560%30$%="-0,"1Q,#0$%@",!"7P(1#70$%H"7#08"#$%`>=>H>MbG%3"%>$$07#"560%J,"$#.&#,"%3"$%?83F$21,#"$%3&%K(V!#7"%@#8"G%J#01&780.0A#"%&%$("$%]$+&7#".#3"23&$%`>J?@?H>bG%3"%>$$07#"560%3"%?83F$1,#"%@",!"7P(1#7"%3&%N&$'(#$"%`?Hd]e@>eC>bG%30%E#83#7"10%3"%?83F$1,#"%3&%N,03(10$%@",!"7P(1#70$%80%]$1"30%3&%E60%N"(.0%`E?HfLE@>eC>b%&%3"%>$$07#"560%J,"$#.&#,"%3"$%?83F$1,#"$%3&%C&3#7"!&810$%g&8D,#70$%`N,Q2g&8D,#270$bG%)"/&,S%"%0+0,1(8#3"3&%3&%"-,#,%80/"$%+",7&,#"$%&%,&B0,5",%0%70!D,27#0%&41&,#0,%-,"$#.&#,09]!+,&$S,#0%-,"$#.&#,0G%80$%/&!0$%8"%

MN)?%Z[\\G%&!%@,"8hB(,1G%>.&!"8)"9

'$%()!*+,%("-.+/$#.0+1$%$"#$+$2$-3#!4.+5(+677.-!(89.+,%(7!:$!%(+5(+;"5<7#%!(+=(%*.>3?*!-(+$+5$+;"73*.7+=(%*(-@3#!-.7+A6,;BC;=;D

!"""""#

4'"%>.&2+'!$%&'()*!#+,-('&+./)*'"%+5.S#*'+')#1%"2*"+'(#'%>%/2#'+')#/>.2%'(+'4I7F=787

E s p e c i a l C P h I P a r i s - F r a n ç a

O T ! $ % & ' ( ) *!# + , - ( ' & + . / ) * U V ' ' ' L * 2 * 1 " # W X # > %, 1 " # W K % S %, 1 " # ' M N O N ! $ % & ' ( ) *!# + , - ( ' & + . / ) * U V ' ' ' L * 2 * 1 " # W X # > %, 1 " # W K % S %, 1 " # ' M N O N ' ' ' O Y

Page 19: Revista Fármacos & Medicamentos (Edição 64)

!"#$%&'"()%(!"#)"*+#&"(,(-%./0'1)"()1(23"0/45"()".(6%73&4".(87%.'1)".(9%01(:"%;7&#<%7(=#<%0;%&*

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

.)$%+/%4)(+).R(')9%)F/3/&/%*)$%&,'/(0/$%*%")$$'@','+*5+/%+/%&)(0*3%&).%*,0*%0/&(),)?'*9%*.",'*3%*$%"3#"3'*$%"3)+2-K/$%)2%./$.)%,*(-*3%"3)+20)$9%$/.%*%(/&/$$'5+*+/%+/%"/$*+)$%'(=/$0'./(0)$%+'3/&')(*+)$%S%,'(D*%+/%"3)+2-C)G%T%&,'/(0/%'($0*,*5$/%()%&).",/B)%'(+2$03'*,%"*3*%.*(0/3%$2*%)"/3*-C)%"3)+20'=*9%)0'.';*(+)%$/2$%3/&23$)$U9%+/$0*&*%*%+'3/0)3*%+*%F:@3'&*%+*%6)/D3'(?/3%1(?/,D/'.9%>',&/%V).)W*(/G>*%6)/D3'(?/3%1(?/,D/'.9%*%:3/*%+/%</$/(=),='./(5

0)%+/%>/?#&')$%1(+2$03'*'$%P%&)($'+/3*+*%2.*%/$03*50P?'*%"*3*%*%&)($),'+*-C)%+/%2.%(/?#&')%3/(0:=/,%/%$2$0/(0:=/,9%)F/3/&/(+)%2.*%$),2-C)%&).",/0*%"*3*%*%)"/3*-C)9%&).%&)(03*0)$%+/%.P+')%/%,)(?)%"3*;)9%")$$'@','0*(+)%*)$%"*3&/'3)$%$/%&)(&/(03*3/.%/.%*0'='5+*+/$%+/%"/$O2'$*%/%+/$/(=),='./(0)%/%&)./3&'*,';*5-C)%+)$%$/2$%"3)+20)$9%/(O2*(0)%*%6)/D3'(?/3%&2'+*%+*%*0'='+*+/%./')9%)2%$/A*9%F*@3'&*-C)%/%$2"3'./(0)%+)$%"3)+20)$%"*3*%)%./3&*+)G!%2('+*+/%1469%&3'*+*%/$"/&'F'&*./(0/%"*3*%*%.)+*5

,'+*+/%+/%0/3&/'3';*-C)9%=/.%$/%$).*3%S$%03*+'&')(*'$%:3/*$%+/%(/?#&')$%+*%/."3/$*9%4)($2./3%X/*,0D&*3/%7./+'&*./(0)$%'$/(0)$%+/%"3/$&3'-C)89%H3/$&3'"0')(%Y/+'&'(/$%7./+'&*./(0)$%=/(+'+)$%$)@%"3/$&3'-C)%.P+'&*8%/%!('.*,%X/*,0D%7E*Z+/%!('.*,8G%X)A/9%)$%(/?#&')$%+*%:3/*%+/%146%3/$")(+/.%")3%&/3&*%+/%[\%+)%F*023*./(0)%+*%6)/D3'(?/3%1(?/,D/'.%()%.2(+)9%)%/O2'=*,/(0/%*% %]LL%.',DK/$GH*3*%?*3*(0'3%0)+*%/B&/,N(&'*%/%$/?23*(-*%*)$%&,'/(5

0/$9%*%/."3/$*%'(=/$0'2%.*'$%+/%^E_%[I%.',DK/$%()$%Z,0'.)$%*()$9%0*(0)%(*%*02*,';*-C)%0/&(),#?'&*%+)$%$/2$%"3)&/$$)$%/%(*$%'($0*,*-K/$%+*%F:@3'&*%O2*(0)%(*%O2*,'F'&*-C)%+*%/O2'"/G%Q`$$*%/$03*0P?'*%/B'?'2%/$F)3-)$%+*%&)."*(D'*%/%F)&)%/.%+/$/(=),=/3%3/&23$)$%*,0*./(0/%/$"/&'*,';*+)$9%*,'*(+)%0)+)%()$$)%!"#!$%&'!%*%(/&/$$'+*+/$%/$"/&RF'&*$%+*%0/3&/'3';*-C)U9%+/0*,D*%>',&/G!%F:@3'&*%(*&')(*,%P%2.*%+*$%

.*')3/$%/%.*'$%.)+/3(*$%+)%a32")%()%.2(+)9%$/(+)%3/$")($:=/,%"/,)%0/3&/'3)%.*')3%=)5,2./%+/%"3)+2-C)%/%*0/(+/%+/.*(+*$%/$"/&RF'&*$%+)$%*02*'$%[%&,'/(0/$%+/%146%@/.%&).)%+)$%03N$%()=)$%"3)5A/0)$%O2/%+/=/3C)%$/3%*"3)=*+)$%()$%"3#B'.)$%./$/$G%Q<'*(0/%+/$0/%&/(:3')9%/$0'.*.)$%*.",'*3%*%"3)+2-C)%/.%.*'$%MI%.',DK/$%+/%2('+*+/$U9%*F'3.*%)%?/3/(0/%+/%>/?#&')$%1(+2$03'*'$%+*%/."3/$*9%!2?2$0)%a/3*,+'GQT%4)(+).R(')%&D/?*%"*3*%*%()$$*%/."3/$*%&).)%

2.*%/$03*0P?'*%"*3*%*.",'*3%*%&*"*&'+*+/%"3)+20'=*%/%)%=),2./%+/%(/?#&')$9%+'$")('@',';*(+)%*)%$/?./(0)%F*35.*&N20'&)%"3)+20)$%&).%O2*,'+*+/%/%$/?23*(-*G%Y*'$%+)%O2/%'$$)9%()$$)%&,'/(0/%")+/3:%F)&*3%)$%/$F)3-)$%(*$%"3#"3'*$%/$03*0P?'*$%+/%./3&*+)9%/(O2*(0)%+/,/5?*%*%"3)+2-C)%*%/$"/&'*,'$0*$%+)%$/0)3G%T203*%?3*(+/%=*(0*?/.%P%O2/%D:%2.*%/."3/$*%'($0*,*+*%/.%()$$)%&).",/B)%'(+2$03'*,%$/?2'(+)%/$0/%.)+/,)9%/%&/30'F'&*+*%"/,*%!>b1E!9%&)."3)=*(+)%*%/F'&'N(&'*%+)%&)(&/'0)%+/%&)(+).R(')%'(+2$03'*,9%3/$$*,0*%!202$0)G!,P.%+'$$)9%*%&3/+'@','+*+/%/%*$%&/30'F'&*-K/$%+*%

F:@3'&*%@3*$',/'3*%")3%*?N(&'*$%3/?2,*0#3'*$%/B0/3(*$9%*02*,./(0/%&)."3//(+/(+)%*$%*?N(&'*$%`23)"P'*$%71(?,*0/33*%/%!,/.*(D*89%!3?/(0'(*%/%4),).@'*(*%P%2.%*03*0'=)%"*3*%)%./3&*+)9%A2(0*./(0/%&).%)%3/$"/'0)%*)$%*$"/&0)$%P0'&)$9%$)&'*'$%/%*.@'/(0*'$G

:71.&0(%*()%.'1>/%X:%)203*%()='+*+/%+*%2('+*+/%*,/.C%()%63*$',c%QT%

&).",/B)%'(+2$03'*,%F)'%/$&),D'+)%"*3*%*%"3)+2-C)%+/%*,?2($%./+'&*./(0)$9%D)A/%F*@3'&*+)$%(*%`23)5"*9%O2/%$/3C)%03*($F/3'+)$%"*3*%)%63*$',%()$%"3#B'5.)$%*()$G%!%F*@3'&*%@3*$',/'3*%$/3:%3/$")($:=/,%"/,*%/B")30*-C)%+/$0/$%"3)+20)$%"*3*%)%./3&*+)%,*0'()55*./3'&*()9%/23)"/2%/%*$':0'&)G%>)=)$%'(=/$0'./(0)$%$/3C)%3/*,';*+)$%"*3*%*+/O2*-C)%+)%'&%!%*)$%=),2./$%3/O2/3'+)$9%*,P.%+/%0/3.)$%3/&/@'+)9%/.%*?)$0)%Z,0'.)9%*%*?N(&'*%3/?2,*0#3'*%*,/.C%"*3*%&/30'F'&*-C)%+*$%,'(D*$%+/%$#,'+)$%"*3*%/B")30*-C)%*)%&)(0'(/(0/%/23)"/2U9%*(2(&'*%!2?2$0)G

?&0$%(@"*"A1#%

B C ! " # $ % & ' (!) * + , & % $ * - . ' ( D E ( ( ( F / ' / G 7 " H ? " 3 %* G 7 " H I % J %* G 7 " ( K L B L ! " # $ % & ' (!) * + , & % $ * - . ' ( D E ( ( ( F / ' / G 7 " H ? " 3 %* G 7 " H I % J %* G 7 " ( K L B L ( ( ( B M

Page 20: Revista Fármacos & Medicamentos (Edição 64)
Page 21: Revista Fármacos & Medicamentos (Edição 64)
Page 22: Revista Fármacos & Medicamentos (Edição 64)

L e g i s l a ç ã o

! !"#$%&'($!"#"$%&#'()%&*+"$,'-&.)#"$/).)$

("%&.('),'0)12"3$ #&4'#)%&*+&$ .&56'7+.)#"$ *)$869*(')$:)('"*),$ #&$;'6',<*(')$=)*'+>.')$?8:;@=8A3$)/.&57&*+)$"$/.)0"$#&$4),'#)#&$'*#'()#"$*)$ &%-),)6&%B$87$ 4).'&#)#&7$ #&$/.)0"7$#&$4),'#)#&$&*("*+.)#"7$&*+.&$"7$#'C&.&*+&7$%&#'()%&*+"7$"D$)+E$%&7%"$&*+.&$%&#'()%&*+"7$7'%',).$"D$6&*E.'("$72"$6.)*#&73$/".+)*+"3$"$FD&$G>$/".$+.>7$#&77)$#&+&.%'*)12"$"D$#&C'*'12"$#"$/.)0"$#&$4),'#)#&H$I$/.)0"$#&$4),'#)#&$#&$D%$/."#D5+"$ )$ 7&.$ ("%&.('),'0)#"$ *"$J.)7',$

Circular para:

)*+,

-./

01 ,1

22

300-*4/

!"#$%&'(#)*#+&,-)&)*#)*#./#$%().0(#&#1*%#2(/*%2-&,-'&)(#3(#4%&1-,#5#)*0*%/-3&)(#$(%#./#*10.)(#)*#*10&6-,-)&)*#)*#,(37&#).%&89(#)*#&2(%)(#2(/#(1#$&%:/*0%(1#)*;-3-)(1#3&#<*1(,.89(#3#=#>?#)*#@A#)*#B.,C(#)*#@DDE#F<G#3=>H@DDEI#>JK

5 5 ! " # $ % & ' (!) * + , & % $ * - . ' ( 6 7 8 8 8 4 & " & 9 # $ : ; $ < => 9 # $ : / = ? => 9 # $ 8 5 @ A @ ! " # $ % & ' (!) * + , & % $ * - . ' ( 6 7 8 8 8 4 & " & 9 # $ : ; $ < => 9 # $ : / = ? => 9 # $ 8 5 @ A @ 8 8 8 5 B

!"#$%&'()*+,-$,./&0-$,-1,./&+2*3*-+-1,-1,41-*)+"1(&$5,6%$-0&$/,-1,718%+-+9:$,1,;1/&1/,./#1)<=*)$/,-1,>)$%-$,)$",?+-+,@$%"+,@+%"+)A0&*)+*CDE#%$8F$!GG$!

Page 23: Revista Fármacos & Medicamentos (Edição 64)

!" #$%$&'()*#+" ,+&" -'" $.%-#+" #$"

$.%*/(0(#*#$" #$" 0+)1*" #-&*23+"#$"

*4+&#+"4+'"+.",*&5'$%&+."#$6()(#+."

)*"7$.+0-23+")"8"9:"#$";<"#$"=-0>+"

#$";??@"A7B")89C;??@D"9E

F"$.%*/(0(#*#$"#$",&+#-%+."6*&'*4G-H

%(4+."#$,$)#$"#$"6*%+&$."*'/($)%*(."

4+'+" %$',$&*%-&*:"-'(#*#$:" 0-I"$"

+-%&+."$.%-#+."&$0*4(+)*#+."*+",&J,&(+"

,&+#-%+:"/$'"4+'+",&+,&($#*#$."6K.(H

4*."$"L-K'(4*."#$".-/.%5)4(*."*%(M*."$"

$N4(,($)%$."6*&'*4G-%(4+.:"6+&'*"6*&H

'*4G-%(4*"$".-*"4+',+.(23+:",&+4$..+"

#$"6*/&(4*23+:"%(,+"$",&+,&($#*#$."#+."

'*%$&(*(."#$"$'/*0*1$'"9E

F"O&1*)(I*23+"P-)#(*0"#*"Q*R#$"

AOPQD"#$6()$"$.%*/(0(#*#$"6*&'*4G-%(4*"

4+'+"*"4*,*4(#*#$"#+",&+#-%+"6*&'*H

4G-%(4+"#$"'*)%$&".-*.",&+,&($#*#$."

L-K'(4*.:"6K.(4*.:"'(4&+/(+0J1(4*."$"

/(+6*&'*4G-%(4*."#$)%&+"#+."0('(%$."

$.,$4(6(4*#+." #-&*)%$" +" ,&*I+" #$"

M*0(#*#$";E

O."$).*(+."#$"$.%*/(0(#*#$"&$*0(I*#+."

)+"S&*.(0:"4-=*"40*..(6(4*23+"!"*"I+)*"

40('T%(4*"UV:"#$M$'".$1-(&"%&G."$.%-#+."

4+)%$',0*#+.")*"7B")8"9C;??@W

" B.%-#+"#$"B.%*/(0(#*#$"F4$0$&*#*W"

F4$0$&*" *" #$1&*#*23+"L-K'(4*"

$C+-"'+#(6(4*2X$." 6K.(4*." #$"

-'" ,&+#-%+" 6*&'*4G-%(4+" $'"

4+)#(2X$." 6+&2*#*." #$" *&'*H

I$)*'$)%+E"O."#*#+."+/%(#+.:"

=-)%+" 4+'" *L-$0$." #$&(M*#+."

#+." $.%-#+."#$" 0+)1*"#-&*23+:"

.3+"-%(0(I*#+.",*&*"*M*0(*&"$6$(%+."

L-K'(4+." $" 6K.(4+.",&+0+)1*#+."

$'"4+)#(2X$.")3+"*4$0$&*#*."$"

,*&*" *M*0(*&" +" (',*4%+"#$" 4-&H

%*."$N,+.(2X$."*"4+)#(2X$."6+&*"

#*L-$0*."$.%*/$0$4(#*.")+"&J%-0+"

#+",&+#-%+:"L-$",+#$'"+4+&&$&"

#-&*)%$"+"%&*).,+&%$Y

" B.%-#+"#$"B.%*/(0(#*#$"#$"Z+)1*"

[-&*23+W"V$&(6(4*"*."4*&*4%$&K.%(H

4*."6K.(4*.:"L-K'(4*.:"/(+0J1(4*."

$"'(4&+/(+0J1(4*."#$"-'",&+#-%+"

6*&'*4G-%(4+"#-&*)%$"$:"+,4(+H

)*0'$)%$:" #$,+(." #+",&*I+"#$"

M*0(#*#$"$.,$&*#+E"O."&$.-0%*#+."

.3+"-%(0(I*#+.",*&*"$.%*/$0$4$&"+-"

4+)6(&'*&"+",&*I+"#$"M*0(#*#$"#$"

-'",&+#-%+"/$'"4+'+"&$4+'$)#*&"

*."4+)#(2X$."#$"*&'*I$)*'$)%+Y

" B.%-#+"#$"B.%*/(0(#*#$"#$"F4+'H

,*)>*'$)%+W"V$&(6(4*"$"4+)6(&'*"

.$"+",&+#-%+"6*&'*4G-%(4+"'*)%!'"

*."4*&*4%$&K.%(4*."6K.(4*.:"L-K'(H

4*.:"/(+0J1(4*."$"'(4&+/(+0J1(4*."

4+)6+&'$"+."&$.-0%*#+."+/%(#+."

)+."$.%-#+."#$"$.%*/(0(#*#$"#$"

0+)1*"#-&*23+E

\F"O&1*)(I*23+"

P-)#(*0"#*"Q*R#$"

AOPQD"#$6()$"

$.%*/(0(#*#$"

6*&'*4G-%(4*"4+'+"

*"4*,*4(#*#$"#+"

,&+#-%+"6*&'*4G-%(4+"

#$"'*)%$&".-*."

,&+,&($#*#$."

L-K'(4*.:"6K.(4*.:"

'(4&+/(+0J1(4*."$"

/(+6*&'*4G-%(4*."

#$)%&+"#+."0('(%$."

$.,$4(6(4*#+."

#-&*)%$"+",&*I+"#$"

M*0(#*#$";]E

! ! ! " # $ % & ' (!) * + , & % $ * - . ' ( " # $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ ! 2 3 2 ! " # $ % & ' (!) * + , & % $ * - . ' ( " # $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ ! 2 3 2 $ $ $ ! 4

Page 24: Revista Fármacos & Medicamentos (Edição 64)

L e g i s l a ç ã o

!""#"$ #"%&'("$ ")($ *#+,-.+'("$ #/$01/+*+"$ (&$ #/$ "+,+"$ 0,-/2%-0+"3$0(/$0(4%*(,#$'#$ %#/5#*+%&*+$ #$'#$&/-'+'#$*#,+%-6+$#$'#6-'+/#4%#$7&+8,-9-0+'+"$#$6+,-'+'+"$5+*+$:+*+4%-*$+$;(/(:#4#-'+'#$#$+$'-"%*-<&-=)($'+$%#/5#*+%&*+$#$'+$&/-'+'#$#/$%('("$("$5(4%("$#/$7&#$+"$+/("%*+"$9-0+/$+0(4'-0-(4+'+"$'&*+4%#$($#"%&'(>?$ 0(/5*(6+=)($ '+$ #"%+<-,-'+'#$

#$ +$'#%#*/-4+=)($'($5*+.($'#$6+8,-'+'#$'("$5*('&%("$ 9+*/+0@&%-0("$(<A#%("$'#$*#:-"%*($"+4-%2*-(3$'#6-'($+$"&+$-/5(*%140-+3$4)($")($+5#4+"$#B-:@40-+$'+$?CDEF?3$/+"$%+/<G/$")($#B-:-'("$5(*$(&%*+"$+&%(*-'+'#"$"+4-%2*-+"3$ 0(/($ 5#,($H#*0+'($I(/&/$'($F&,$ JH!KILFMNO3$5#,+$!&*(5#+4$?:#40P$9(*$%;#$!6+,&+%-(4$(9$H#'-0-4+,$Q*('&0%"$J!H!?O3$5#,+$R(('$+4'$S*&:$?'/-"%*+%-(4$JRS?O3$5#,+$L*:+4-.+=)($H&4'-+,$'+$F+T'#$JLHFO3$#4%*#$(&%*+">L"$#"%&'("$'#$#"%+<-,-'+'#$%+/<G/$

")($ 4#0#""2*-("$ 5+*+$ ("$ '-6#*"("$5*(0#""("$5U"8*#:-"%*(">$S#$+0(*'($0(/$ +$ K#"(,&=)($ 4V$ WX3$ '#$ Y$ '#$(&%&<*($'#$Z[[\$JKSI$WX][\O$^3$+"$/('-9-0+=_#"$*#,+0-(4+'+"$`$,(0+,$'#$

9+<*-0+=)(3$`$#7&-5+/#4%(3$+($5*(80#""($'#$5*('&=)(3$+("$#B0-5-#4%#"3$`$-40,&")($'#$4(6($+0(4'-0-(4+/#4%(3$+($ 92*/+0(3$ +($ %+/+4;($ '($ ,(%#3$+($5*+.($'#$6+,-'+'#3$+("$0&-'+'("$'#$ 0(4"#*6+=)(3$ `$ +%&+,-.+=)($ '#$#"5#0-9-0+=_#"$#$+("$/G%('("$+4+8,a%-0("$'($5*('&%($ +0+<+'($'#6#/$"#*$+6+,-+'+"$#$6#*-9-0+'+"$7&+4%($+$4#0#""-'+'#$'+$*#+,-.+=)($'($#"%&'($'#$#"%+<-,-'+'#$'#$+0(*'($0(/$0+'+$/('-9-0+=)($#46(,6-'+>?$*#+,-.+=)($'($#"%&'($'#$#"%+<-,-8

'+'#$G$'#$#B%*#/+$-/5(*%140-+$5+*+$+"$-4'T"%*-+"$9+*/+0@&%-0+"3$5(-"$4($/(/#4%($'($*#:-"%*(3$5U"8*#:-"%*($#$*#4(6+=)(3$'#6#*)($"#*$0(4"-'#*+'("$#$+5*#"#4%+'("$'#5#4'#4'($'#$0+'+$0+"($ #"5#0a9-0($ #$ '#$ +0(*'($ 0(/$0+'+$5*(0#""(>

!"#$%&#'($)($)*"+$+,-#b('($/#'-0+/#4%($5(""&-$*#:-"%*+'($

($,-/-%#$'#$#"5#0-9-0+=)($5+*+$($%#(*$'($5*-40a5-($+%-6($#$G$5(""a6#,$7&#$(0(**+$&/+$%#4'@40-+$'#$7&#'+$'($%#(*$'&*+4%#$($#"%&'($'#$#"%+<-,-'+'#3$+5*#"#4%+4'($+($9-4+,$'($#"%&'($&/+$5(*0#4%+:#/$'#$7&#'+$#/$*#,+=)($+($

/(/#4%($-4-0-+,3$5(*G/$+%#4'#4'($+$#"5#0-9-0+=)($'($5*('&%(>$D2*-("$")($("$ 9+%(*#"$ *#,+0-(4+'("$`$ %#4'@40-+$'#$7&#'+$#$4#0#""-%+/$"#*$+6+,-+'("$#$#"%&'+'("3$'#"'#$+$9(*/&,+=)($#$($5*(0#""($'#$9+<*-0+=)($'($5*('&%(3$+$0+*+0%#*a"%-0+$'($+%-6(3$($/+%#*-+,$'#$#/<+,+:#/3$#4%*#$(&%*(">$L$5(4%($/+-"$-/5(*%+4%#$+$"#*$0(4;#0-'($%+,6#.$"#A+$+$5(""-<-,-'+'#$'+$9(*/+=)($'#$5*('&%("$'#$'#:*+'+=)(3$'#$"&<"%1480-+"$*#,+0-(4+'+"$(&$'#$-/5&*#.+">HG%('($-/5(*%+4%#$5+*+$+6+,-+*$+$

"#:&*+4=+$#$+$#9-020-+$'($/#'-0+/#4%($G$($/(4-%(*+/#4%($'#$9(*/+=)($'#$5*('&%("$'#$'#:*+'+=)(3$7&#$5('#/$:#*+*$5#*'+$'#$+%-6-'+'#$%#*+5@&%-0+$(&$+%G$/#"/($'#$%(B-0-'+'#>L"$5*('&%("$ '#$ '#:*+'+=)($ ")($

-/5&*#.+"$*#"&,%+4%#"$'#$+,%#*+=_#"$7&a/-0+"3$ 7&#$ 5('#/$(0(**#*$ 4($5*(0#""($'#$9+<*-0+=)($'($92*/+0($#$'($/#'-0+/#4%(3$4($+*/+.#4+/#4%($8$"(<$#9#-%("$'+$,&.3$'+$%#/5#*+%&*+3$'($5c$#$'+$&/-'+'#$8$#$4($%*+4"5(*%#$(&$ +-4'+$4+$ -4%#*+=)($'($ 92*/+0($0(/$($#B0-5-#4%#$#](&$0(4%+%($0(/$+$#/<+,+:#/$5*-/2*-+>$M/+$ '+"$ 5*-40-5+-"$ 0+&"+"$ '+$

d?$*#+,-.+=)($'($#"%&'($'#$#"%+<-,-'+'#$G$'#$#B%*#/+$-/5(*%140-+$5+*+$+"$-4'T"%*-+"$9+*/+0@&%-0+"3$5(-"$4($/(/#4%($'($*#:-"%*(3$5U"8*#:-"%*($#$*#4(6+=)(3$'#6#*)($"#*$0(4"-'#*+'("$#$+5*#"#4%+'("$'#5#4'#4'($'#$0+'+$0+"($#"5#0a9-0($#$'#$+0(*'($0(/$0+'+$5*(0#""(>e

. / ! " # $ % & ' (!) * + , & % $ * - . ' ( 0 / ( ( ( 1 % & % 2 " # 3 4 # 5 )6 2 " # 3 7 ) 8 )6 2 " # ( . 9 : 9 ! " # $ % & ' (!) * + , & % $ * - . ' ( 0 / ( ( ( 1 % & % 2 " # 3 4 # 5 )6 2 " # 3 7 ) 8 )6 2 " # ( . 9 : 9 ( ( ( . ;

Page 25: Revista Fármacos & Medicamentos (Edição 64)
Page 26: Revista Fármacos & Medicamentos (Edição 64)

L e g i s l a ç ã o

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

+!.%456*(6#*<,6(0$6#*()*()3,%(%456*)#$G* ,)'%.!6"%(6* F* #)30,%"4%* (6#*-)(!.%-)"$6#?* <6!#* <6()* 6.6,,),*

%* +6,-%456*()*<,6(0$6#* $AC!.6#* )H60*%*<),(%*<%,.!%'*60*$6$%'*(%*%$!9!2(%()*$),%</0$!.%*(6*+G,-%.6?*#)"(6*!-<6,$%"$)*&0#.%,*6*!#6'%-)"$6*)*%*.%,%.$),!>%456*(%#*<,6<,!)(%()#*+8#!.%*)*708-!.%?*%##)30,%"(6*%*#)30,%"4%*&!6'A3!.%*%*<%,$!,*(%*()$),-!"%456*(6#*"89)!#*()* #)30,%"4%*%.)!$G9)!#*)*()*'!-!$)#*()*70%"$!+!.%456?*.6-*,)'%456*F*<6#6'63!%*(!G,!%*I:;%,%*6*()#)"96'9!-)"$6*)*%*9%'!2

(%456*()*-)$6(6'63!%#* !"(!.%$!9%#*()* )#$%&!'!(%()?* <,).6"!>%2#)* %*,)%'!>%456*()* $)#$)#*()*)#$,)##):*J*6&K)$!96*(6#*)"#%!6#*()*()3,%(%456*+6,4%(%*1*<,6-69),*0-%*()3,%(%456*()*<)70)"%*)C$)"#56?* %9%'!%"(6*6*.6-<6,$%-)"$6* (6* +G,-%.6* )* (6*-)(!.%-)"$6*-)(!%"$)* %#* .6"(!24@)#*-%!#* #)9),%#?* #0+!.!)"$)* <%,%*()#)"96'9),*)*9%'!(%,*%*-)$6(6'63!%*

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

!".'0!*6#*)+)!$6#*.%0#%(6#*<)'%*9%,!%456*

RE-<6,$%"$)*+%$6,*,)+),)"$)*F*!()"$!+!.%456*(6#*<,6(0$6#*()*()3,%(%456*)#$G*,)'%.!6"%(6*F*#)30,%"4%*(6#*-)(!.%-)"$6#?*<6!#*<6()*6.6,,),*%*+6,-%456*()*<,6(0$6#*$AC!.6#*)H60*%*<),(%*<%,.!%'*60*$6$%'*(%*%$!9!(%()*$),%</0$!.%*(6*+G,-%.6?*#)"(6*!-<6,$%"$)*&0#.%,*6*!#6'%-)"$6*)*%*.%,%.$),!>%456*(%#*<,6<,!)(%()#*+8#!.%*)*708-!.%?*%##)30,%"(6*%*#)30,%"4%*&!6'A3!.%*%*<%,$!,*(%*()$),-!"%456*(6#*"89)!#*()*#)30,%"4%*%.)!$G9)!#*)*()*'!-!$)#*()*70%"$!+!.%456?*.6-*,)'%456*F*<6#6'63!%*(!G,!%*I:S

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( " # $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ ! 2 3 2

Page 27: Revista Fármacos & Medicamentos (Edição 64)

!"#$%&'%("$)("*#!"#)&+!"!%#,-)".!/#"'(/'(+"!/0*#!"#/1+!"23/*#!"#4/$56+7%#%#!"# 7)78%$+9+6+!"!%#:#;+!(56+7%#'/(#%1$%.7"#<"(+"23/#!/7#<"6/(%7#!%#=8+>!/?9"7%*#-)%# 73/#8/.!+2@%7# $A'+8"7#!%#!%B("!"23/#!%#4=(&"8/7#CD#E%B)%#!%4+.+23/# (%7)&+!"# !/7# '(+.8+'"+7#$%7$%7#%1%8)$"!/7#%#"<"6+"!/7#!)(".$%#/#%.7"+/F# G+!(56+7%F#H#=B)"#I#8/.7+!%("!"#8/&/#)&#!/7#'(+.8+'"+7#8"$"6+7">!/(%7#%&#(%"2@%7#!%#!%B("!"23/*#B%(".!/#-)%9("#!"#&/6I8)6"#!%#4=(&"8/#'%6"#"23/#!"#=B)"# >#"#=B)"#I#)&#(%"B%.$%#JD

# K1+!"23/F#H#!%B("!"23/#/1+!"$+<"#I#)&"#!"7#'(+.8+'"+7#8")7"7#!%#+.7$"9+6+!"!%#!%#4=(&"8/7D#L%"23/#-)%#/8/((%#."#'(%7%.2"#!%#/1+>BM.+/*#8/&#/#B".;/#!%#/1+BM.+/#/)#'%(!"#!%#;+!(/BM.+/#ND

# O/$56+7%F# H# 6)P# QR# "4%$"# "7#6+B"2@%7# -)A&+8"7# 4/(.%8%.!/#%.%(B+"# '"("# "# 7%'"("23/# !/7#%6I$(/.7# 8/&'"($+6;"!/7# %.$(%#/7#!/+7#=$/&/7#!%77"#6+B"23/#CD

# S7$"9+6+!"!%#TI(&+8"F#H#".=6+7%#$I(&+8"# '/77+9+6+$"# )&"# "&'6"#4"+1"#!%#"'6+8"23/#'"("#&%!+!"7#!%# '(/'(+%!"!%7# 4A7+8"7*# 8/&/#%7$)!/# !%# (%"2@%7# -)A&+8"7*#"<"6+"23/#!"#%7$"9+6+!"!%#$I(&+8"*#!%$%(&+."23/#!"#8/&'/7+23/#!%#&"$%(+"+7#%#!%7%.</6<+&%.$/#!%#&%$/!/6/B+"#"."6A$+8"#CD

U)(".$%# "# %1%8)23/#!/7# %.7"+/7#!/7#$%7$%7#!%#!%B("!"23/#4/(2"!"#I#+&'/($".$%#8/.7+!%("(#"#)$+6+P"23/#!/#'6"8%9/#'"("#"<"6+"(#"#+.$%(4%(M.8+"#!/7# %18+'+%.$%7*# /# 4=(&"8/# +7/6">!/*#%#."#4/(&)6"23/#!/#'(/!)$/*#I#+&'/($".$%#'"("#/9$%(# +.4/(&"2@%7#

(%4%(%.$%7#:7#(/$"7#!/7#'(/!)$/7#!%#!%B("!"23/*# +.8/&'"$+9+6+!"!%#!/#4=(&"8/#%#%18+'+%.$%#%#"#8/.4+(&"23/#!"# %7'%8+4+8+!"!%# !"#&%$/!/6/B+"#"."6A$+8"#'"("#/#!/7%"&%.$/#!/#"$+</D

!"#$"#%"#&"'()*'+#%'+,)+-."%)+-./%)/-./'01$*'/U%.$(%#/7#$%7$%7#"<"6+"!/7#./7#%7>

$)!/7#!%#%7$"9+6+!"!%#I#!%$%(&+.".$%#8/.;%8%(#"#"'"(M.8+"#!/#'(/!)$/*#/#$%/(#!/#'(+.8A'+/#"$+</#%#/7#6+&+$%7#&+8(/9+"./7D# H# -)".$+4+8"23/# !%#'(/!)$/7# !%# !%B("!"23/# $"&9I&#'/!%(=#7%(#.%8%77=(+"#!%'%.!%.!/#!"# 8"("8$%(A7$+8"# !/# "$+</# /)# !/#&%!+8"&%.$/D#H6I&#!/7#$%7$%7#!%7>8(+$/7#%1+7$%&#"7#'"($+8)6"(+!"!%7#%#%7'%8+4+8+!"!%7#!/7#$%7$%7#!%#"8/(!/#8/&#8"!"#4/(&"#4"(&"8M)$+8"D#H6B).7#!%77%7#$%7$%7#7%(3/#"'(%7%.$"!/7#!%#

!"#$%&'()(*+,$%-.(/0#10%2.(032#0*+.&%4.40(0(%3"5.67"'

!"#$%&'(%$%)*+

!"#$%&'()*"#$+,- .'"/,0$!/'1*"$+,-

!"#$%&!'(")*"+(,-&(.&$.!"#$%&!'(".)*"+(,-&(.&$.!"#$%&!'("./0"1$#$%&!'("1$#$%&!'(".2("-1(3+(.0

!"23!'("!1#3(1!'$2!10"(%!'$2!10"(,!'("!1+"*1!'$%-""(3!'$2!11-&!'("!1.#!)$1-&!'("!1./4&3(0/"(3-&$1-&!'("!1.1!"$!5(

!"#$1-$+2#$+,3!#*1$+,6*$5-!2-%!.+*1!3!5(

#$%'(4".1$53(%-&!'("1$53(%-&!'("

!"#$.!+#'4$!",-

-)(0(%!'(".%-53!5(1-0(%!'(".%-53!5(

!"#$56"7$+,-

!7'"#'-3+!40$,8!-+9(!4'-3

0-"()5!'("0-23(+-#3!5(

&$1"2#$+,-/$1-5!35!3!5(.&$.'("2-&$1

!"#$%&'()*$%+,'&-.,/0123454'67894'57'%2:;'<=='>'?5/'@78A48@43B73C'>'DE'>'+0EF'=GHII>JHH!KL7F'MM'NJJO'HP<Q><P=='>'!4RF'MM'NJJO'HP=P>IJGP7>S4C8F'TK3SC8UTK3SC8/VKS/W3'

,9#4,-

#$%'$5-1-&$./4&3(0/"(3-&$*%&$0-"-%!5(.&$.'-%0(

14,09#,-3",8,-

$5!2/$&3-%!./0"+"*%-53!'$2!1+"*3!'$2!1.&-/4&3(0/"(3-&$1(&!+-%-"2)$*&($2/$&3-%!./0"2)$*&($2/$&3-%!.)*"+!5(

Page 28: Revista Fármacos & Medicamentos (Edição 64)

L e g i s l a ç ã o

!"#$%&#'()$*+%,&-"#.$&+'$"/(0#%/1+"&%& %-2*3%45",& %& *$-"#06/3*%& '& %&3"/0#*7)*45"&-%#%& %& ('8)#%/4%&'& %&9)%2*+%+'&+"&$'+*3%$'/0":;&-#*$'*#"&0'(0'&%&('#&%-#'('/0%+"&

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

-"*(&'(0'&.&)$&!%0"#&3%-%B&+'&%3'12'#%#& ")&+'&+*$*/)*#& %& >'2"3*+%+'&+'& #'%4F'(:&A(& -#*/3*-%*(& #'%4F'(&'/>"2>*+%(& /%& +'8#%+%45"& +'& !<#1$%3"(&(5"&%&C*+#G2*('&'&%&"H*+%45"&'&%$7%(&-"+'$&('#&3%0%2*(%+%(&-"#&<3*+"(&'I")&7%('(:&J'&%3"#+"&3"$&%&K'("2)45"&/L&MNIOMMP,&-%#%&%(&!"#$%(&

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

()(-'/(F'(&.&)$&0'(0'&9)'&%-#'('/10%&3"$"&"7?'0*>"&>'#*!*3%#&"&=/+*3'&+'& ('+*$'/0%45":&T$%& ()(-'/(5"&*+'%2&-"(()*&3"$"&3%#%30'#=(0*3%(&%&+*$*/)*45"&+%&>'2"3*+%+'&+'&('-%1#%45":&;&-#"+)0"& #'+*(-'#("&+'>'&%-#'('/0%#& %(-'30"& C"$"8Q/'"& '&+)#%/0'&%&%#$%B'/%8'$&/5"&-"+'#<&C%>'#&3#'(3*$'/0"&+'&3#*(0%*(:A&32%#*+%+'&'$&("2)4F'(&.&)$&0'(0'&

9)'& '(0<& #'2%3*"/%+"& @& %-%#Q/3*%&+"& -#"+)0",& /"& 9)%2& %& %>%2*%45"&+%&3"#&+'&2=9)*+"(&.&'H'3)0%+%&-"#&

3"$-%#%45"&+%&("2)45"&("7&%/<2*('&1&-#'-%#%+%&3"/!"#$'&*/(0#)4F'(&+%&$"/"8#%!*%&1&'&("2)4F'(&-%+#5"&+'&3"#:&A(&("2)4F'(1%$"(0#%&+'>'$&('#&-#'-%#%+%(& +'&$"+"& %& %-#'('/0%#&3"2"#%45"&('$'2C%/0'&@&+%&("2)45"&+'&#'!'#Q/3*%&'(-'3*!*3%+%&NN:&;& 0'(0'&+'& ('-%#%45"&+'& !%('&'$&

'$)2(F'(&'&3#'$'(&"7?'0*>%&%>%2*%#&"&-#"+)0"&3"/0*+"&/%&'$7%2%8'$&-#*$<#*%&'&>'#*!*3%#&('&C<&%&('-%#%45"&+'&!%(':&U"#&+'!*/*45",&'$)2(5"&.&%&$*(0)#%&'/0#'&+"*(&2=9)*+"(&*$*(3=>'*(&'$&9)'&)$&+'2'(&V%&!%('&+*(-'#(%W&'/3"/0#%1('&/%& !"#$%&+'& !*/"(&82G7)2"(&/"& ('*"&+"&")0#"& 2=9)*+"& V%& !%('& 3"/0=/)%W,&!"#$%/+"&)$%&$*(0)#%& '(0<>'2:&A(&'$)2(F'(,&$%*(&3"/C'3*+%(&3"/(*(0'$&+'&<8)%&'&G2'":&A(&'$)2(F'(&(5"&*/(10<>'*(&0'#$"+*/%$*3%$'/0'&',&3"$&"&0'$-",&0'/+'$&%&#'0"#/%#&-%#%&"&'(0%+"&'(0<>'2&+'&G2'"&('-%#%+"&+%&<8)%:&;(&%8'/0'(&'$)2(*!*3%/0'(&V")&()#!%30%/0'(W&(5"&()7(06/3*%(&%+*3*"/%+%(&@(&'$)21(F'(&-%#%&%)$'/0%#&%&()%&'(0%7*2*+%+'&3*/.0*3%& 0"#/%/+"1%(& #%B"%>'2$'/0'&'(0<>'*(&'&C"$"8Q/'%(&NO:A&+)#'B%&.&)$&0'(0'&9)'&+'0'#$*/%&

%& #'(*(0Q/3*%&$'36/*3%&+"&3"$-#*1$*+"&%"&'($%8%$'/0":&J'&%3"#+"&3"$& %& X%#$%3"-.*%& Y#%(*2'*#%,& %&

ZA&!*/%2*+%+'&+"&0'(0'&.&%>%2*%#&-#*$'*#%$'/0'&('&%&'$7%2%8'$&-#*$<#*%&.&%+'9)%+%&%"&-#"+)0"&',&%2.$&+*((",&8%#%/0*#&9)'&"&-#"+)0"&/5"&-'#+')&)$*+%+'&+'>*+"&%"&!#%(3"&('$*1-'#$'<>'2:[

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % ! 3 4 3 ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % ! 3 4 3 % % % ! 5

Page 29: Revista Fármacos & Medicamentos (Edição 64)
Page 30: Revista Fármacos & Medicamentos (Edição 64)

L e g i s l a ç ã o

!"""""#

!"#$%&'( )'*++'*! "! #$%&'%&(! )*! +%$*,-.%! ./&'01$.%2! 3)2%!4/.5)$0.&%&)!6$%7!8'9%0!:468;<!)03)-.%2.01%!)*!2.&)$%/=%!-($3($%1.5%!3)2%!4/.5)$0.&%&)!&)!>(#.! &%0!8$'7)0! :4>8;?!@1'%2*)/1)! "! +%$*%-A'1.-(! $)03(/0,5)2! 3)2%!-(($&)/%=B(!&(0! )01'&(0! &)! )01%9.2.&%&)! &)!*)&.-%*)/1(! 0C2.&(0! /%! ./D&E01$.%!+%$*%-A'1.-%?

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

)*9%2%#)*!)!&)!1$%/03($1)?N./%2*)/1)<!I,!1)01)!&)!&.00(2'=B(<!

G')! &)1)$*./%! %! 3($-)/1%#)*!&%!G'%/1.&%&)!&)!3$./-L3.(!%1.5(<!&)-2%D$%&(!/(!$C1'2(!&(!3$(&'1(<!2.9)$%&(!/(!*).(!&)!&.00(2'=B(<!&)/1$(!&(!3)$L(&(!&)! 1)*3(!)03)-.+.-%&(!/%!*(/(#$%+.%!&)!-%&%!3$(&'1(<!G'%/&(!(!*)0*(!"!0'9*)1.&(!F!%=B(!&)!%3%D$)2I%#)*!)03)-L+.-%<!0(9!-(/&.=O)0!)P3)$.*)/1%.0!&)0-$.1%0?!H!1)01)!5.0%!&)*(/01$%$! 0)!(!3$(&'1(!%1)/&)!F0!)P.#A/-.%0!-(/01%/1)0!&%!*(/(#$%+.%!&(!*)&.-%*)/1(!3%$%!-(*3$.*.&(0!)!-,30'2%0! JQ?!@0!)03)-.+.-%=O)0!&(!1)01)!&)!&.00(2'=B(!5%$.%*!-(/+($*)!

(!+,$*%-(<!(!*).(<!(!&.03(0.1.5(<!%!-2%00.+.-%=B(!+%$*%-A'1.-%<!)/1$)!('1$%0?H'1$(0!1)01)0!('!)01'&(0!%&.-.(/%.0!

3(&)$B(!0)$! $)-(*)/&%&(0!3%$%!(0!)01'&(0!&)!)01%9.2.&%&)<!-(/0.&)$%/&(D0)!+%1($)0!)!%32.-%9.2.&%&)0!)03)-L+.-%0!&)! %-($&(! -(*! -%&%! 3$(&'1(! ('!+($*%!+%$*%-A'1.-%?R.%/1)!&(0! 1)*%0!%3$)0)/1%&(0<!(!

(9S)1.5(!&)01)!%$1.#(!"!&)*(/01$%$!%!.*3($1M/-.%!&(!)01'&(!&)!)01%9.2.&%&)!&)!*)&.-%*)/1(!)!%3$)0)/1%$<!&)!+($*%!$)0'*.&%<!%2#'/0!1)01)0!G')!./1)#$%*!('!G')!3(&)*!./1)#$%$!)00)!)01'&(<!)01%9)2)-.&(0! ('! $)-(*)/&%&(0! %!3%$1.$!&%0!2)#.02%=O)0!5.#)/1)0?

J?!6$%0.2?!T)0(2'=B(!/U!VJ<!&)!WX!&)!S'2I(!&)!WVVY?!Z'.%!3%$%!%!$)%2.D7%=B(!&)!)01'&(0!&)!)01%9.2.&%&)?

W?![\H?!Z((&!R.01$.9'1.(/!]$%-D1.-)0!:ZR];!+($!]I%$*%-)'1.-%20!]$(&'-10?!R.03(/L5)2!)*^!I113^__`` ?̀̀ I(?./1_*)&.-./)0_0)$5.-)0_)P3)$1-(**.11))0_3I%$*3$)3_a@bcVdeT)5WcZR]&$%+1?3&+?!@-)00(!)*!JY?VX?WVJV?

K?!6$%0.2?!T)0(2'=B(!TR8!fU!Qe<!&)!Vd!&)!H'1'9$(!&)!WVVX?!R.03O)!0(9$)!%!$)%2.7%=B(!&%!%21)$%=B(<!./-2'0B(<!0'03)/0B(!)!-%/-)2%*)/1(!3C0D$)#.01$(!&)!*)&.-%*)/1(0!)!&,!('1$%0!3$(5.&A/-.%0?

Q?!g/1)$/%1.(/%2! 8(/+)$)/-)! (/!\%$*(/.0%1.(/!:g8\;!(+!1)-I/.-%2!$)G'.$)*)/10! +($! $)#.01$%1.(/!(+!3I%$*%-)'1.-%20!D!b1%9.2.1h!i)01./#!(+!f)`!R$'#!b'901%/-)0!%/&!]$(D&'-10!aJ@!:TW;<!WVVK?!R.03(/L5)2!)*^! I113^__```?.-I?($#_-%-I)_-(*3(_KdKDWjWDJ?I1*2?!@-)00(!)*!JX?VX?WVJV?

!"#"$%&'()*+,(-.(/0$1#(')*

Y?!b.25%! klT<! @25)0! mRb<! b(%$)0!>NT<!]%00(0!T8b<!N%$.%!@T<!T(2.*!f)1(!]n?!>(&)2(0!&)!%5%2.%=B(!&%! )01%9.2.&%&)! &)! +,$*%-(0! )!*)&.-%*)/1(0!3%$%! %! ./&E01$.%!+%$*%-A'1.-%?!T)5.01%!&)!8.A/-.%0!N%$*%-A'1.-%0!6,0.-%!)[email protected]%&%?<!WVVXoKV:W;^JWXDJKY?

d?!@/0)2!\8<!](3(5.-I!fZ<!@22)/Dn$!mp?!N%$*%-(1"-/.-%^!+($*%0!+%$*%D-A'1.-%0!q!0.01)*%0!&)!2.9)$%=B(!&)!+,$*%-(0?!e?!)&?!]($1(!@2)#$)^!@$1*)&o!WVVj?!]?!jjY?

j?!N2($)/-)!@i<!@11`((&!R?!]$./-L3.(0!+L0.-(DG'L*.-(0!)*!+%$*,-.%?!K?)&?!bB(!]%'2(^!l&'03o!WVVK?!3?!jJJ?

e?!>($.`%r.!8<!6$)0-%/0./!lZ<!\.(r%!f<!>%.(/-I.!N<!>%1.(2.!Z?!l01'&(!&%!&)#$%&%=B(!&(!+,$*%-(!f%9'D*)1(/%!3($! +(1C2.0)!&.$)1%?!@-1%!b-.?!WVVJo!WK:K;^dYJDQ?

X?!N%$*%-(3".%!6$%0.2).$%?! Q?! l&?!bB(!]%'2(^!@1I)/)'<!JXee?!p?J?W!R)1)$*./%=B(! &)! p(2'*)! )*!

N($*%0!N%$*%-A'1.-%0?

JV?!N%$*%-(3".%!6$%0.2).$%?!Q?!l&?!bB(!]%'2(^!@1I)/)'<! JXee?!p?W?JX?!R)1)$*./%=B(!&(!3\?

JJ?!N%$*%-(3".%!6$%0.2).$%?!Q?!l&?!bB(!]%'2(^!@1I)/)'<!JXee?!p?W?JW!8($!&)!mLG'.&(0?

JW?!]Tgbi@?! m?!f(#').$%?! @mplb<!@?!8($$).%?!i"-/.-%!N%$*%-A'D1.-%! )! N%$*,-.%!Z%2"/.-%?! Q?!)&?!m.09(%^!N'/&%=B(!8%2('01)!Z'29)/r.%/<!JXXW?

JK?!N%$*%-(3".%!6$%0.2).$%?!Q?!l&?!bB(!]%'2(^!@1I)/)'<!JXee?!p?J?K?J?!R'$)7%!:JXee;?

JQ?!N%$*%-(3".%!6$%0.2).$%?! Q?! l&?!bB(!]%'2(^!@1I)/)'<!JXee?!p?J?Y!R)1)$*./%=B(! &(! 1)*3(! &)!&.00(2'=B(!3%$%!-(*3$.*.&(0!)!-,30'2%0!:JXee;?

JY?!T)5.0O)0^! @$1.#(! $)5.0%&(! 3($!@2./)!8%$&(0(<!l&'%$&(!T%*%2I(!)!i(0I.(!g&%?

! " ! $ % & ' ( ) *!# + , - ( ' & + . / ) * # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % 3 " 4 " ! $ % & ' ( ) *!# + , - ( ' & + . / ) * # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % 3 " 4 " % % % 5 6

Page 31: Revista Fármacos & Medicamentos (Edição 64)
Page 32: Revista Fármacos & Medicamentos (Edição 64)

I n s t a l a ç õ e s e P r o j e t o s F a r m a c ê u t i c o s

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % " 3 4 3 ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % " 3 4 3 % % % ! !

!!"#$%&"'()*+,* -)./'0,-*1"$,23,$"%-4*

)-*&)25,&%+)-*-)$)-4*6)+%!%&)/7-,*"*

1"$3%$*+)*6"$&)*$,8/."39$%)*,-3"#,.,&%+)*

,6*:;;<4*=/,*+,3,$6%2"4*1"$"*3)+"-*

"-*,61$,-"-*+)*6,$&"+)*#$"-%.,%$)4*

&)2+%'0,-*+,!%2%+"-*"+,=/"+"6,23,*

1"$"*"*!"#$%&"'()*+,-3,-*6,+%&"6,23)-**

%61)$3"23,-*1"$"*"*-">+,*5/6"2"*,4*

&,$3"6,23,4* )-*6,+%&"6,23)-* =/,*

6"%-*-".?"6*?%+"-*2)*6/2+)@

A*=/,*2()*5"?%"*2"*$,8/."'()*,$"*

"*=/"23%!%&"'()*+)*2B?,.*+,* $%-&)*"*

=/,* ,-3"?"6* -/C,%3)-* )-* 1"&%,23,-*

=/,* ,-3"?"6* -/#6,3%+)-* D* 3,$"1%"*

%2!/-%)2".* "* 1"$3%$* +"*/3%.%E"'()*+"*

-)./'()*1"$,23,$".*,6*-%-3,6"*"#,$3)4*

&)6)*6,+%&"6,23)*)/*&)6)*?,B&/.)@*

F* G,-)./'()* 2H* IJ* KGLM* 2H* IJN*

+"*F8O2&%"*P"&%)2".* +,*Q%8%.R2&%"*

S"2%3T$%"* KFPQUSFN* 2()* -)6,23,*

,-3"#,.,&,/* "-* &)2+%'0,-* 3$"2-%397

$%"-* 1"$"* "* "+"13"'()*+)-* -%-3,6"-*

+,* !"#$%&"'()*+"-* ,61$,-"-4* &)6)*

,-3"#,.,&,/*"-*$,-1)2-"#%.%+"+,-*+,*

3)+"*"*&"+,%"4*%2&./-%?,*2"*3$"3"3%?"*

+"+"*D-*%2?,-3%8"'0,-*+)-*"&%+,23,-*

,2?).?,2+)*"-*S)./'0,-*V"$,23,$"%-*+,*

W$"2+,*Q)./6,*KSVWQN*2)*/-/T$%)*1,.)*

5)-1%3".4*1)%-*)*,.,6,23)*1$)1/.-)$*

+"*.,8%-."'()*1"$"*6)+%!%&"'0,-*+"-*

SVWQ*!)%*,X"3"6,23,*)*1$,--/1)-3)*

!"#$%&'()%*+,#-.#/,01*2./#3%'.45.'%(/6#,/#),47.)(-,/#/,',/6#8,-($(),19/.#%#3%'5('#-,#8%'),#'.:10%5;'(,#./5%&.0.)(-,#.8#<==>6#?1.#-.5.'8(4%6#3%'%#5,-%/#%/#.83'./%/#-,#8.')%-,#&'%/(0.(',6#),4-(*2./#-.$(4(-%/#%-.?1%-%8.45.#3%'%#%#$%&'()%*+,#-./5./#8.-()%8.45,/##(83,'5%45./#3%'%#%#/%@-.#718%4%#.6#).'5%8.45.6#,/#8.-()%8.45,/#?1.#8%(/#/%0A%8#A(-%/#4,#814-,BC

Circular para:

566

78&17767

9:

;;

!"#$%&#'(%()*'&+,+-.%'(/+"0+123&41+'(5(6#,3-.%'(!+"%*&%"+4'(7%(8"+*7%'(9#,30%'(<+=+%>'?2%@A?BC

7D1

6:E8@9

Page 33: Revista Fármacos & Medicamentos (Edição 64)
Page 34: Revista Fármacos & Medicamentos (Edição 64)

I n s t a l a ç õ e s e P r o j e t o s F a r m a c ê u t i c o s

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # " $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ 2 3 4 3 ! " # $ % & ' (!) * + , & % $ * - . ' ( # " $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ 2 3 4 3 $ $ $ ! 5

!"#$%"#&#'()*&#+&,"-*(./#-.#(-0%)1&#"'.#2'.-!"3#+&'45#-1&#5"-)%'.!&6#2'.-!"#"5#0%-71&#!.)#*&-!(78")#!"#0.9'(*.71&# !&#5&!"/&# :(2"-,"# !"#)(),"5.#.9"',&# "3# ,.59453#2'.-!"#"5#0%-71&#!.#0./,.#!"#*&-;"*(5"-,&)#-.# +&-,.3# -&)# ;&)+(,.()3# !"# *&5&#5.-(+%/.'# "# (-0%-!('# .# <=>?# "5#*&-!(78")#)"2%'.)@#A),"#*&-B%-,&#!"#0.,&'")#*'(.:.#%5#

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

9&/).)@#S+R)#'"/"59'.'#&#+.)).!&3#4#-"*"))T'(&#)"#0./.'#!&#+'")"-,"@#U./.K)"#)&9'"#&)#5.(&'")#!").0(&)#

'"/.*(&-.!&)#L)#(-),./.78")#(-!%),'(.()#"#.&#0%-*(&-.5"-,&#!"#+/.-,.)#0.'K5.*N%,(*.)#+'&!%,&'.)#!"#)&/%78")#+.'"-,"'.()3# -&# *.)&# !"# 2'.-!")#:&/%5")3#5.)# $%"# )"# .5+/(.# "5#/(-;.)#2"'.()#.#(-),./.78")#!"!(*.!.)#.#<&/%78")#=.'"-,"'.()#!"#="$%"-&)#?&/%5")# V<==?W3# '")+"(,.-!&K)"#.)#!":(!.)# +'&+&'78")# !"# +"$%"-&)#:&/%5")3#&%#)"B.3#.)#<=>?#"#.)#<==?@X-(*(.K)"#:./&'(P.-!&#%5.#!&*%K

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

!(),'(9%Q!&# "5#2.9.'(,&)# -.# 0&'5.#!"#"59./.2"-)@#D&-)(!"'.K)"# $%"# .# ")*&/;.# !&#

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

]U./.K)"#)&9'"#&)#5.(&'")#!").0(&)#'"/.*(&-.!&)#L)#(-),./.78")#(-!%),'(.()#"#.&#0%-*(&-.5"-,&#!"#+/.-,.)#0.'5.*N%,(*.)#+'&!%,&'.)#!"#)&/%78")#+.'"-,"'.()3#-&#*.)&#!"#2'.-!")#:&/%5")3#5.)#$%"#)"#.5+/(.#"5#/(-;.)#2"'.()#.#(-),./.78")#!"!(*.!.)#.#<&/%78")#=.'"-,"'.()#!"#="$%"-&)#?&/%5")#V<==?W3#'")+"(,.-!&K)"#.)#!":(!.)#+'&+&'78")#!"#+"$%"-&)#:&/%5")3#&%#)"B.3#.)#<=>?#"#.)#<==?@̂

Page 35: Revista Fármacos & Medicamentos (Edição 64)

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # " $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ 2 3 4 3 ! " # $ % & ' (!) * + , & % $ * - . ' ( # " $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ 2 3 4 3 $ $ $ ! 5

!"#"$%&'(#)"#$*%)"$+*,"-+"$.$/,'(#0)"-)*$1&*$*$"$'2"-)"$%*3"$'2()"+"$%(4#*$&,$)*##*-($1&*$#*5-"$"26&-%$")#/4&)(%78*-9(2$"1:;<*#($'#(<&-+($1&*$-=($

*%)*3"$>(-)",/-"+($>(,$?6&"$+*$"2)"$,/-*#"4/2/+"+*$ *$ 1&*$ -=($ '(%%&"$>(-)",/-"9@*%$ <;%/>(01&;,/>"%$ *$(#6A-/>"%$ /,'(#)"-)*%$ -($ )*##*-(B$(#/&-+"%$ +"$ '#C'#/"$ ")/D/+"+*$E&0,"-"$ -($ 2(>"2B$ *,$ "26&,$ )*,'($'C%0")/D/+"+*$/-+&%)#/"27F*)*#,/-"#$ %*$ "$'2"-)"$ %*#?$ D*#0

)/>"2$(&$E(#/G(-)"2$ )",4.,$.$&,"$+*>/%=($/,'(#)"-)*$"$%*#$)(,"+"$*,$

<&-9=($+"$?#*"$+/%'(-;D*2$D*#%&%$($)","-E($+($ *,'#**-+/,*-)($1&*$%*$1&*#$>(-%)#&/#7$!(+*0%*$>(-%)#&/#$)",4.,$'2"-)"%$

1&*$#*>*4",$<(#-*>/,*-)($+*$?6&"$"$ '"#)/#$ +($ %/%)*,"$,&-/>/'"2$ +*$"4"%)*>/,*-)(7$ !(#.,B$ *%)"$ ?6&"$.$ )#")"+"B$,(+/</>"-+($ "$ *%)"9=($+*$'#(+&9=($+*$?6&"$'"#"$/-3*9=(B$'(/%$ %*#?$ -*>*%%?#/($ #*)/#"#$ ($ 1&*$<(/$ "+/>/(-"+($ "$ *%)"$ ?6&"$ '"#"$)(#-?02"$ '()?D*2B$ '(/%$ "$ ?6&"$'"#"$/-3*9=($ >(,'(#)"$ "'*-"%$ -;D*/%$/-</-/)*%/,"/%$ +*$,/-*#"4/2/+"+*$ *$

6"%*%$ +/%%(2D/+(%B$ *$ )",4.,$&,"$4"/H;%%/,"$ >(-+&)/D/+"+*$ *2.)#/>"B$!E$"+*1&"+($*)>7I%$,.)(+(%$ +*$ (4)*-9=($ +*%)"$

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

'#(D"$ +*$ <(#,"9=($ +*$ 4/(</2,*%$*H/6*$+"$*-6*-E"#/"$&,"$/,'(#)"-)*$/-)*#<">*$>(,$"$>/L->/"$<"#,">L&)/>"B$'(/%$($>(-E*>/,*-)($+"$*-6*-E"#/"$

678'9:9;<.88(>"2M1&/'",*-)($N$OPQR")*#/"2O)/2/+"+*%S*#)/</>"9@*%

=9'.)>9>8R").#/"%0'#/,"%R")*#/"2$+*$*,4"2"6*,R")*#/"2$%*>&-+?#/(M%'*>/</>"9@*%S*#)/</>"9@*%

!*%%("2$N$T#*/-",*-)(I'*#"9@*%

R*+/>",*-)(%$/-3*)?D*/%

UI%$,.)(+(%$+*$(4)*-9=($+*%)"$?6&"$'"#"$/-3*9=($%=($+/<;>*/%$'"#"$"%$*,'#*%"%B$'(/%$"$2*6/%2"9=($'#*>(-/G"$1&*$*%)"$?6&"$+*D*$")*-+*#$($'*#</2$<;%/>($1&;,/>(B$4/(2C6/>($*$,/>#(4/(2C6/>($>(-%)"-)*$-"%$<"#,">('./"%$*&#('./"%$*$",*#/>"-"%$")&"2/G"+"%7V

?>@&)9$4$A$B8C&./9$D9E)F*

Page 36: Revista Fármacos & Medicamentos (Edição 64)
Page 37: Revista Fármacos & Medicamentos (Edição 64)
Page 38: Revista Fármacos & Medicamentos (Edição 64)
Page 39: Revista Fármacos & Medicamentos (Edição 64)

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % 3 4 5 4 ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % 3 4 5 4 % % % ! 6

!"#$%#&'()*$%#!&+,-.*.$%#./#&$#($%#./0&%(1#&$ 2(-$ !"#$ &"#$ 3+&43-+&$*$ #15#$ !06$)-&)#$2(-$ -7+&'*)$ -$-&'-8*)$3+3#&9$:$ -!;-!5*.+*$ /#,-$'(,#$,-&,-$2(-$&-8*)$%#!&+,-.*,*&$'#,*&$*&$!(*!%-&$,*&$%+<!%+*&$-&/-=%+*1+>*,*&$-$*,8*%-!'-&6$&#?$/-!*$,-$'#.!*.$#$/.#8-'#$()$)#&*+%#$&(?$#($&(/-.,+)-!&+#!*,#$ %*.#$ -$ /#(%#$-@+%+-!'-6$2(*!,#$!"#$)*1$*%*?*,#$-$!"#$3*1+,A3-19:&$1-;+&1*BC-&$/-.'+!-!'-&$D$/.#,(=

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

,-$)-+#&$@+1'.*!'-&$2(-$%#!&+,-.*)$&-/*.*,*)-!'-$ #&)#&-$ +!3-.&*$ -$,-&'+1*B"#9$K*%+#%4!+#$*!A1#;#$-$/-1#&$@J.(!&$ +!'-.@*.)*%#/-+%#&$ &-;(-)$

#&$%*)+!5#&$-!'.-$*&$/#&&+?+1+,*,-&$,-$-&'-.+1+>*B"#$/#.$!"#$%&''$#($/-1#$(&!()$*#+6$,#+&$%#!%-+'#&$2(-$!"#$%#!%#..-)$-$2(-$&"#$*%-+'#&$%#)#$3A1+,#&9$:$ '-!,<!%+*$*/#!'*$2(-$*$0!+%*$3-.'-!'-$/#&&43-1$/*.*$,-@+!+.$&-$#$)-,+%*)-!'#$+!8-'A3-1$,-3-$#($!"#$ &-.$ -&'-.+1+>*,#$/#.$!"#$%&''6$ -$-&'*$3-.'-!'-$3*.+*!'-$F6$!*$3-.,*,-6$*$'-.)#1*?+1+,*,-$,#$/.+!%4/+#$*'+3#$-$&-(&$*,8(3*!'-&6$2(*!,#$!-%-&&A.+#&6$-$!"#$)*+&$#$/#!'#$,-$*)#1-%+)-!'#$,*$-)?*1*;-)9E&&-$ '-)$ &+,#$#$,-&*@+#$,*&$ -)=

/.-&*&6$ /#+&$ !"#$ 5A$ '-%!#1#;+*&$,+&/#!43-+&$ !#$L.*&+1$ /*.*$ *'-!,-.$*$ -&'*&$,-)*!,*&6$ &-!,#$!-%-&&A=.+#6$ @.-2M-!'-)-!'-6$ 2(*!,#$ !"#$)*!,*'J.+#6$1#%*1+>*.$'-%!#1#;+*$,-$@#.)*B"#6$,-$-!3*&-6$,-$-!%5+)-!'#$-$,-$@-%5*)-!'#$,-$%#!'<+!-.-&$!#$-7'-.+#.6$ +!+%+*!,#$()$ +)/#.'*!'-$/.#%-&&#$,-$*/.#7+)*B"#$-$,-$&+!=%.#!+&)#$,-$%(1'(.*&$!*$)#!'*;-)$,-$()$/*.2(-$ %#)/1-7#$/-1*$ &(*$/.J/.+*$-&/-%+@+%+,*,-9N-)/.-$#?8-'#$,-$,03+,*&6$*&$2(-&=

'C-&$,+)-!&+#!*+&$,*&$('+1+,*,-&$-$#&$,-&-!%#!'.#&$,-$+,+#)*&$-&'"#$&-)=/.-$-)$,-&'*2(-6$*)-*B*!,#$'#.!*.$#$/.#8-'#$()$)#&*+%#$ +!-7-2M43-1$

2(*!,#$!"#$)(+'#$?-)$;-.-!%+*,#9O(-$*$+!,0&'.+*$@*.)*%<('+%*$('+=

1+>-$ -&'-$ '+/#$,-$-7/-,+-!'-$!"#$F$!#3+,*,-9$H#+$!#3+,*,-6$-!'.-'*!'#6$/*.*$#&$-)/.--!,-,#.-&$-)$NPQR$2(-$&-$,-/*.*.*)$%#)$-&'*$.-*1+,*=,-6$#($&-8*6$*$+)/#&&+?+1+,*,-$,-$&-.$/.#,('+3#$*$/#!'#$,-$/-.)*!-%-.$!#$)-.%*,#$&-)$()$+)/#.'*!'-$*;.-=;*,#$ '-%!#1J;+%#$ 2(-$)+!+)+>-$ *$+!%#./#.*B"#$,-$)"#=,-=#?.*$,+.-'*$/.+!%+/*1)-!'-$!*&$@*&-&$%.+'+%*&$,#$/.#%-&&#6$#$2(-$/#'-!%+*1+>*$#$.+&%#$,*$%#!'*)+!*B"#9S*$@*?.+%*B"#$,-$NPQR$*$-&'-.+1+=

>*B"#$'-.)+!*1$F$)(+'#$+)/#.'*!'-9$T$ /.#,('#$ */.-&-!'*$ ,+)-!&C-&$,-&%#)(!*+&$&-$%#)/*.*,#&$*$#('.#&$+!8-'A3-+&$-$&J1+,#&$-$*$/.#?*?+1+,*=,-$ ,-$ %#!'*)+!*B"#$ -&'A$ &-)/.-$/.-&-!'-6$ &-!,#$)(+'#$?-)$)#!+='#.*,*$!*&$?#*&$/1*!'*&$ -7+&'-!'-&$!#&$ P*4&-&6$ /#.F)$ '#,*$ *$ %*,-+*$1#;4&'+%*$ '*)?F)$/#,-$ *;.-,+.$ *&$NPQR$-6$-3-!'(*1)-!'-6$'-)=&-$!*$/#!'*$()$ .-&(1'*,#$-)$,-&*%#.,#$%#)$*$@#'#;.*@+*$,#$/.#,('#$*#$&*+.$,*$@*?.+%*B"#9E)$()*$-)/.-&*$-&'.('(.*,*$+!,(&=

'.+*1)-!'-6$*$@(!B"#$-)-.;-$,-$&(*$/.J/.+*$3#%*B"#6$,-3-!,#$'*)?F)$

US*$@*?.+%*B"#$,-$NPQR$*$-&'-.+1+>*B"#$'-.)+!*1$F$)(+'#$+)/#.'*!'-9$T$/.#,('#$*/.-&-!'*$,+)-!&C-&$,-&%#)(!*+&$&-$%#)/*.*,#&$*$#('.#&$+!8-'A3-+&$-$&J1+,#&$-$*$/.#?*?+1+,*,-$,-$%#!'*)+!*B"#$-&'A$&-)/.-$/.-&-!'-6$&-!,#$)(+'#$?-)$)#!+'#.*,*$!*&$?#*&$/1*!'*&$-7+&'-!'-&$!#&$P*4&-&6$/#.F)$'#,*$*$%*,-+*$1#;4&'+%*$'*)?F)$/#,-$*;.-,+.$*&$NPQR$-6$-3-!'(*1)-!'-6$'-)=&-$!*$/#!'*$()$.-&(1'*,#$-)$,-&*%#.,#$%#)$*$@#'#;.*@+*$,#$/.#,('#$*#$&*+.$,*$@*?.+%*B"#9V

Page 40: Revista Fármacos & Medicamentos (Edição 64)

I n s t a l a ç õ e s e P r o j e t o s F a r m a c ê u t i c o s

!"#$%"&'($)%#'&*#)#+&,-!./')0#$&/!#)# %"!$&1!)2/+/3)3"# 3&# 4)2%/')1."#!&*"1."#."%*/1)#5()13&#&#$%&3(.&#6#/14(13/3&#'&*#!('"!!&#1&#$)'/"1."789#(*)# /*$&%.)1."#'&*2/1):;&#

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

$%""13/*"1.&#?/!)#+('%)./?/3)3"#"#)#'&13/:;&#!"#$%&'(%#)##$)%)#&#.%E1!/.&#3"#*"%')3&%/)0#'&*&#*"3/')*"1.&!0#

1"!."#*(13&#,+&2)+/@)3&0#6#&#5("!/.&#5()+/3)3"0#.;&#/*$&%.)1."#5("#3"?"#"!.)%#"*#(*)#$)(.)#3"#3/!'(!!;&7#F#%"!$&1!)2/+/3)3"#3&!# 4&%*(+)3&%"!#3"#"*$%""13/*"1.&!#/1/'/)#'&*#)!#"!'&+<)!#5("#!;&#4"/.)!#)/13)#1)#4)!"#$%6D$%&>".&0#'&*&#)#$%&!$"':;&#3)#."13=1'/)# 3"# '&1."/1"%/@):;&0# 3"#%"!/1)!#)!'"13"1."!#"#%"!/1)!#3"!'"1D."!0#3"#!/.():;&#%",(+).G%/)#1&#C)-!0#"#'&*&#1;&#3/@=D+&0#)!#'&13/:A"!#3"#*"%')3&0# !"# '&*$%)3&%0# ?"13"3&%#&(#"5(/+/2%)3&7F# '&*2/1):;&# /1)3"5()3)# 3)!#

"1,"1<)%/)!#$&!!-?"/!#"#)#5()!"#)(D!=1'/)#3)#"1,"1<)%/)# 4)%*)'=(./')#'&*&#"!$"'/)+/3)3"#3"# 4).&0# .&%1)#&#$%&'"!!&#*(/.)!#?"@"!#')%&#5()13&#1;&# /1)$%&$%/)3&7#H)%&#$&%5("#!;&#*(/.&!#&!#/1."%"!!"!#"B/!."1."!#"*#$%&D>".&!#3"#,%)13"!#3/*"1!A"!7#F#'/=1'/)#4)%*)'=(./')#1;&#6#)+,&#"*$-%/'&0#6#')+'(+)3)0#$&%#/!!&#(./+/@)D!"#)#5()1D./3)3"#!(4/'/"1."#$)%)0#)#*&."#3)#'&/!)#4)%*)'=(./')0#5("#$&3"#!"%#*)!')%)3)#!"#4&%*(+)3)0#'&1!/3"%)13&D!"#&(#1;&#)!#1"'"!!/3)3"!#/1.%-1!"')!#3&#$%&>".&0#

'(/3)13&D!"#$)%)#3"/B)%#!)-3)!#$)%)#)(*"1.&#3"#3"*)13)!#"#5("#)#+/1<)#3"#4)2%/'):;&#!">)#!(4/'/"1."*"1."#4+"B-?"+#$)%)#)'&+<"%#(*#"?"1.()+#)(*"1.&#3"#$&%.4G+/&!#3)#"*$%"!)#"# /1'+(!/?"#$%&3(.&!# /1'%"*"1.)/!#'&*#!/1"%,/)#%"+)./?)#&(#)2!&+(.)7I#1"'"!!9%/&# "1."13"%0# %",(+)3&%#

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

4(1:;&#3"#*6.&3&!#)+."%1)./?&!#$)%)#

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

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # ! $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ 2 " 3 "

Page 41: Revista Fármacos & Medicamentos (Edição 64)
Page 42: Revista Fármacos & Medicamentos (Edição 64)

I n s t a l a ç õ e s e P r o j e t o s F a r m a c ê u t i c o s

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # ! $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ " 2 3 2 ! " # $ % & ' (!) * + , & % $ * - . ' ( # ! $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ " 2 3 2 $ $ $ 4 5

!"#$%"$%"#&%#%"$%'()(&*&%#+*,$*&!"#%-#.'!"*#%#/%'"!#.%)!"#%".%+(*)("$*"#%-#01*)(&*&%#&!"# (,2%$3/%("4#-*"#+12!#%,$%,&(-%,$!#"%#$%-4#%"$%#+!,+%($!#+!-!# "!5'%.12*&!#01%#%"$*$("$(+*6-%,$%# !# '%01("($!# ,7!# !8%'%+%# *"#9*'*,$(*"#,%+%""3'(*"#%-#81,:7!#&!#$*-*,;!#&!"# )!$%"#%<("$%,$%"4#.*'*#!"# $%"$%"#&%# %"$%'()(&*&%4#.!&%,&!#"%'# *.)(+3/%)# ,!# +*"!#&!"#-!,($!6'*-%,$!"# &!# *+!-.*,;*-%,$!#&!#,=/%)#&%#+!,$*-(,*:7!#*!#)!,9!#&%#$!&!#!#.'!+%""!>?"$%# @#!1$'!# +*.=$1)!#&*#;("$A'(*#

&*"# "!)1:B%"# (,2%$3/%("4#-*"# 01%#+%'$*-%,$%#%"$*'3#%-#$!&*"#*"#.*1$*"#&%#&("+1""7!#%#.15)(+*:B%"#'%91)*$A6'(*"#&*#C*'-*+!.@(*#D'*"()%('*#%#&*#EFGHIE#%,$'%#JKLK#%#JKLL>

67(.)89:*$;8)8/<')7=8M%/(&!# *# +'($(+(&*&%# &*# INOG#

&1'*,$%# *# 8*5'(+*:7!4# "%#,7!#;!16/%'# 1-#.'!+%""!# '!51"$!# +!-#1-#(-.!'$*,$%# *9'%9*&!# $%+,!)A9(+!4#

*# .'!5*5()(&*&%#&%#!#.'!&1$!# "*('#+!,$*-(,*&!#@#.!$%,+(*)-%,$%#-*(!'>I%#.!'#1-#*".%+$!#,7!#%<("$%#1-#

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

01%#*+*5*'3#.!'#/*)!'(T*'#!# (,/%"$(6-%,$!#01%#8!(#'%*)(T*&!#,!"#.*'01%"#(,&1"$'(*("# %# ,*# "1*# !'9*,(T*:7!4#*.)(+*,&!4#"%-.'%#01%#+!-.%$%,$%4#!#+!,+%($!#&%#)(5%'*:7!#.*'*-@$'(+*4#

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

91)*$A'(!#01%#%"$3#"%,&!#&%"%,/!)/(&!#%#&%)%#.*'$(+(.*'6"%4#"%2*#,*#C*'-*+!6.@(*#D'*"()%('*4#"%2*#,*"#M('%$!'(*"#%#I%+'%$*'(*#&*#C*'-*+!.@(*#D'*"()%('*#"%&(*&*#,*#EFGHIE>

!"#"$%&'($)*'+(#@#9'*&1*&!#%-#8*'-3+(*#%#5(!01=-(+*#.%)*#[,(/%'"(&*&%#?"$*&1*)#N*1)("$*#\]V)(!#&%#^%"01($*#C();!_#X[F?INY4#.A"69'*&1*&!#%-#01*)(&*&%#.%)*#[,(/%'"(&*&%#&%#I!'!+*5*#X[FHI`Y4#^DE#%-#9%"$7!#%-.'%"*'(*)#.%)*#C1,&*:7!#O%$V)(!#G*'9*"#XCOGY4#.A"6^DE#%-#9%"$7!#%-.'%"*'(*)4#,%9A+(!"#%#)!9="$(+*#.%)*#[,(/%'"($a#!8#Q*)(8!',(*#X?"$*&!"#[,(&!"#&*#E-@'(+*#6#?[EY>#E$1*)-%,$%#@#/(+%6.'%"(&%,$%#&*#E""!+(*:7!#D'*"()%('*#&%#N'!&1$!'%"#&%#I!6)1:B%"#N*'%,$%'*("#XEDPEINY#%#&('%$!'#&*#I%9-%,$*#C*'-*+U1$(+*>

!/////)

Page 43: Revista Fármacos & Medicamentos (Edição 64)
Page 44: Revista Fármacos & Medicamentos (Edição 64)

G a r a n t i a e C o n t r o l e d a Q u a l i d a d e

! ! ! " # $ % & ' (!) * + , & % $ * - . ' ( " ! # # # $ % & % ' ( ) * + ) , -. ' ( ) * / - 0 -. ' ( ) # 1 2 3 2 ! " # $ % & ' (!) * + , & % $ * - . ' ( " ! # # # $ % & % ' ( ) * + ) , -. ' ( ) * / - 0 -. ' ( ) # 1 2 3 2 # # # ! 4

! 5&()6%78)!"#$%&"'#" ()'*+,-(#" .#-/#012,(0#3"

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

,-(.#/0#1$#'*()"*$#.*.23('4/(.#*/(*%"*#/3(2/%5(62%47*'.4('84(/472'%2(7"#%4/(04'02#%4/(62$*%#9*72'%2(6202'%2/3(7*/(%*7!:7(4"%64/(.2(26*/(16202.2'%2/3(0474(*/(.*(#'/12;84(23(7"#%4(2/120#*$72'%23(4/(.4(04'%64$2(2/%*%</%#04(.4(16402//4=>

Circular para:

99:;;

;<

=< >?$/

@)(6A#B)&-&#-#CD%()#/E#F)(-&&)

G?H=

>I/

H+=

!"#"$%&'("$)*+,*+-*$."%&("$)*/+'+0*1'+2#'+"+*+0*1*+3"4'5&*

Page 45: Revista Fármacos & Medicamentos (Edição 64)

! ! ! " # $ % & ' (!) * + , & % $ * - . ' ( " ! # # # $ % & % ' ( ) * + ) , -. ' ( ) * / - 0 -. ' ( ) # 1 2 3 2 ! " # $ % & ' (!) * + , & % $ * - . ' ( " ! # # # $ % & % ' ( ) * + ) , -. ' ( ) * / - 0 -. ' ( ) # 1 2 3 2 # # # ! 4

!"#$%&$'($)*"+,*($#*#-." )/%"#$*%"*0,*$%."-%01"2-0/3*)#/")4/"%/3-)0-"3,$0/%" &/)&-$0/%" 2-(*0$5*3-)0-" 2-6&-)0-%."3*%"0*3783"/,02/%"#-"-2*%"'2-&-#-)0-%."&/3/"*%"#*"$)%'-94/"-."3,$0/"-%'-&$*(3-)0-."/%"#/"&/)02/(-"-%0*0:%0$&/"#/"'2/&-%%/;<"'2/&,2*"#-"&/)%/($#*94/"#-%%-%"

&/)&-$0/%" =/$"5$5-)&$*#*"*"-2*"5*($6#*94/."3*%" 0*3'/,&/" %-"/70-5-"/"):5-("#-"%->,2*)9*"'-2%->,$#/"'/2+,-"/"*(5/"3*$/2" &/)%$%0-" -3"/=-2-&-2"%->,2*)9*"*/%"'*&$-)0-%"+,-",0$($?*3"/%"3-#$&*3-)0/%" -" )4/" *'-)*%" /"&/)02/(-"#/"'2/&-%%/"'2/#,0$5/;"@3"*>/%0/" #-" ABBC." *" $)$&$*0$5*"

#*%" DEF" #/" %8&,(/" GGH." (*)9*#*"'-(*"F//#"*)#"I2,>%"!#3$)$%02*0$/)"JFI!K")/20-"*3-2$&*)*."%-25$,"'*2*"(-372*2"+,-"*$)#*"%-"-%01"(/)>-"#/"*(5/;"@%0-"-3'2--)#$3-)0/">*)L/,"#$3-)%4/" $)0-2)*&$/)*(")/"%-$/"#*"H)0-2)*0$/)*(" M/)=-2-)&-"N*23/6)$?*0$/)" JHMNK" -" *'2-%-)0/,"3*0-62$*($?*94/" )*%" %,*%" !"#$%&#'%(" #-"+,*($#*#-"$#-)0$=$&*#*%"&/3"*"(-02*"

O;"@%0*%"#$2-02$?-%"=/2*3"%,73-0$#*%"*"&/)%,(0*%"'P7($&*%"-"$)0-2)*($?*#*%"'-(*"EL*23*&-,0$&*(%" *)#"Q-#$&*("I-5$&-%"!>-)&R"JEQI!K"S*'/)-%*."*"@,2/'-*)"Q-#$&$)-%"!>-)&R"J@Q@!K"-,2/'8$*"-"'-(*"'2T'2$*"FI!;"U->,)6#/" *" )/5*" 5$%4/." *" +,*($#*#-"+,-")4/"'/#-" %-2" *)*($%*#*." 0*3'/,&/"'/#-"%-2"=*72$&*#*."%-"*)0-%")4/"=/2"&/)&-7$#*."/"+,-"8"-V'2-%%/"&/3/")"*&#+,-.,-$%(#!'"JHMN"OWK;!"+,*($#*#-"8"-%02,0,2*#*"#,2*)6

0-" *" &/)&-'94/" #/"3-#$&*3-)0/"-" #/" %-," '2/&-%%/." &/3"5$%0*%" */"#-%-3'-)L/" 0-2*'X,0$&/" '2-5$%0/")/%"'*&$-)0-%;"I-'/$%" 8"#-%-)5/(65$#*."'-23*)-)0-3-)0-"'2/#,?$#*."3*)0$#*"-"*'-2=-$9/*#*")/"%-$/"#-",3" %$%0-3*" #-" +,*($#*#-" 2/7,%0/"JHMN"OCBK;"@%0-"%$%0-3*"'/%%,$"#/$%"=*&$($0*#/2-%Y" /" >-2-)&$*3-)0/" #/"2$%&/"-"#/"&/)L-&$3-)0/;M*#*",3*"#-%0*%"3/#$=$&*9Z-%"0-3"

>-2*#/"#P5$#*%"-"'2/5/&*#/"$)&-20-6?*%")/%"-%0*7-(-&$3-)0/%"$)#,%02$*$%"=*23*&X,0$&/%Y"["+,-"8"$%%/\"M/3/"

]!"+,*($#*#-"8"-%02,0,2*#*"#,2*)0-"*"&/)&-'94/"#/"3-#$&*3-)0/"-"#/"%-,"'2/&-%%/."&/3"5$%0*%"*/"#-%-3'-)L/"0-2*'X,0$&/"'2-5$%0/")/%"'*&$-)0-%;"I-'/$%"8"#-%-)5/(5$#*."'-23*)-)0-3-)0-"'2/#,?$#*."3*)0$#*"-"*'-2=-$9/*#*")/"%-$/"#-",3"%$%0-3*"#-"+,*($#*#-"2/7,%0/"JHMN"OCBK;"@%0-"%$%0-3*"'/%%,$"#/$%"=*&$($0*#/2-%Y"/">-2-)&$*3-)0/"#/"2$%&/"-"#/"&/)L-&$3-)0/;̂

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

%$%0-3*"#-"+,*($#*#-"=*23*&X,0$&*."/"'2$3-$2/"2-(*0$5/"*/">-2-)&$*3-)0/"#/"2$%&/">*)L/,"&-20*"=*3$($*2$#*#-."'/$%" )4/" 8" ,3" &/)&-$0/" )/5/" -."*(83"#$%%/." *" HMN"O_"8"#-#$&*#*"-V&(,%$5*3-)0-" *" -(-;"[" %->,)#/."'/283."/">-2-)&$*3-)0/"#/"&/)L-6&$3-)0/."8"04/")/5/"-"/7S-0$5/"+,-">-2*21"3,$0*%"#P5$#*%"-"$)&-20-?*%;"U-)#/"*%%$3."3-2-&-",3*"'2/=,)#*"

Page 46: Revista Fármacos & Medicamentos (Edição 64)

G a r a n t i a e C o n t r o l e d a Q u a l i d a d e

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( " ! # # # $ % & % ' ( ) * + ) , -. ' ( ) * / - 0 -. ' ( ) # 1 2 3 2 ! " # $ % & ' (!) * + , & % $ * - . ' ( " ! # # # $ % & % ' ( ) * + ) , -. ' ( ) * / - 0 -. ' ( ) # 1 2 3 2 # # # ! 4

!"#"$%&'()(*+'*+$%&'!+%),+'*&$-+."*)/&$"$0-&12*&($+$"$0-&%+((&(345&$6$ -"-&$%&'(*"*"-7(+8$'"($+,7

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

"'C.)(+8$ (+,$"$ )'*+'=5&$1+$+(@&*"-$+((+$0-&%+((&$1+$-+<.+95&3

5-(-6789.-6&)#:)#7)6;-78.-6&)F+@2'1&$"$1)-+*-)G$ HIJ$KLM8$@+7

-+'%)",+'*&$1&$%&'!+%),+'*&$6$2,$+'<&A2+$()(*+,C*)%&$0"-"$"$"A2)()=5&8$"$ "'C.)(+8$ &$ "-,"G+'",+'*&$ +$ "$1)((+,)'"=5&$ 1"$ )'<&-,"=5&$ -+."7%)&'"1"$%&,$0-&12*&(8$0-&%+((&($+$%&,0&'+'*+(3N"-"$ +'*+'1+-$ +(*"$ 1+<)')=5&$ 6$

'+%+((C-)&$%&'()1+-"-$1&)($"(0+%*&($A2+$'+."$+(*5&$%&'*)1&(8$&2$(+#"O$"$)'<&-,"=5&$+$"$(+AE:'%)"$"A2)()=5&$$ "'C.)(+$ $ "-,"G+'",+'*&$ $

1)((+,)'"=5&3$ P"*&($ &2$1"1&($ (5&$)'<&-,"=>+(3$4&$ +'*"'*&8$ "$ )'<&-7,"=5&$(&,+'*+$0&((2)$(+'*)1&$"&$(+$*-"'(<&-,"-$+,$%&'!+%),+'*&8$)(*&$68$A2"'1&$6$%&,0-++'1)1"$+$"1A2)-)1"$0+.&$+(*21&$&2$0+."$+90+-):'%)"3Q.6,$ 1)((&8$ "$ )'<&-,"=5&$ 1+/+$

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

1&$ %&'!+%),+'*&$ 6$ %"0*"-$ <"*&($ +$1"1&(8$ %&,0-++'1:7.&(8$ <).*-C7.&(8$%&.&%C7.&($"$1)(0&()=5&$1&($ )'1)/B712&($0"-"$&($A2")($0&1+,$(+-$R*+)($+$@2"-1C7.&($+'A2"'*&$0&((",$+9)(*)-$)'*+-+(("1&($'+.+(3

<)(#=%-#>#6-7-??@(89# 9# A-?&B)#:)#7)6;-78.-6&)CQ$)')%)"*)/"$1"($VNP$1&$(6%2.&$WWH$

'+%+(()*"$ A2+$ "($ 1+%)(>+($ 1+/",$+(*"-$(2(*+'*"1"($'"$%):'%)"$+$2*).)7G"-$2,$+'<&A2+$;"(+"1&$'"$"'C.)(+$1&$ -)(%&3$?(("($12"($0-+,)(("($ (5&$),0&((B/+)($1+$%&+9)(*)-+,$(+,$A2+$

%),+'*&$+(*+#"$,+(,&$0+-1)1&8$ (+$&($ )'1)/B12&($A2+$&$1+*)'!",$'5&$+(*)/+-+,$,")($'"$+,0-+("3S8$0&-*"'*&8$+/)1+'*+$"$'+%+(()1"1+$

1+$ *-"'(<&-,"-+,$ 1"1&($ +$ )'<&-7,"=>+($ +,$%&'!+%),+'*&8$ %&,$"$<)'".)1"1+$1+$2*).)GC7.&$<2*2-",+'*+8$(+$<&-$'+%+((C-)&3$

D.'8&)#:-#9EF879GB)#:)#7)6;-78.-6&)Q$ (+AE:'%)"$ 1&$ @+-+'%)",+'*&$

1&$%&'!+%),+'*&$XH8A%(9#3Y8$1+(1+$"$"A2)()=5&$1&($1"1&($"*6$"$1)((+7,)'"=5&$1"($)'<&-,"=>+(8$1+/+$(+-$"0.)%"1"$1+$,"'+)-"$()(*+,C*)%"$"&$.&'@&$1+$ *&1&$&$%)%.&$1+$/)1"$1&($0-&12*&(8$&2$(+#"8$1+(1+$"$%&'%+0=5&$"*6$"$%+(("=5&$1"$%&,+-%)".)G"=5&3$

H8A%(9#3#I$5-(-6789.-6&)#:)#7)6;-78.-6&)#9)#F)6A)#:)#787F)#:-#,8:9#:-#%.#.-:879.-6&)

J)67-EGB)

P"*&(

9=%8?8GB)# #96@F8?-# #9(.90-69.-6&)# #:8??-.869GB)

P"*&( P"*&( P"*&( P"*&(

K(96?L-(M6789 N9F8:9GB) <():%GB) O%?E-6?B)

Page 47: Revista Fármacos & Medicamentos (Edição 64)
Page 48: Revista Fármacos & Medicamentos (Edição 64)

G a r a n t i a e C o n t r o l e d a Q u a l i d a d e

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # ! $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ 2 3 4 3

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

G')# -$%).#'$#'$-$*?)>?0/$*%)#&"."#"#&.)'3+,)H@#?">0'"+,)#$#&.)'3+,)#.)%0*$0."# "%I# "# '$-()*%0*3"+,)# '"#4"5.0("+,)#')#&.)'3%)#"#0*4)./"+,)#C$."'"#*"# 4"-$#'$# ()*($&+,)# -$.K#'$&3."'"#$#"&$.4$0+)"'"6F#?)>3/$#'$#0*4)./"+,)#*$($--K.0)#

&"."# "# C$-%,)# "'$B3"'"# '"# B3">01'"'$# '$# 3/#/$'0("/$*%)# (.$-($#$-&$%"(3>"./$*%$6# 7>I/# '0--)@# I#&.$(0-)# ()*-$.?K1>)# $# $T&"*'01>)#()*%0*3"/$*%$6#M/#)3%."-#&">"?."-@#LK#3/#()*L$(0/$*%)#(3R"#C$-%,)#I#*$($--K.0"#'$-$*?)>?$.6#U$/#C$-%,)#')#()*L$(0/$*%)#")#>)*C)#')#(0(>)#'$#?0'"#*,)#LK#-$C3."*+"#'"#B3">01'"'$@#'"#$40(K(0"#$#'"#-$C3."*+"#')#&.)'3%)6#M/#.$-3/)@#I#*$($--K.0)#-$#$-%.3%3.".#3/#-3&$.#EFE#B3$#()*-0C"#"./"8$*".#)#%)')@#)#()*L$(0/$*%)#0*$.$*%$# ")# &.)'3%)@# &"."# &)'$.#C$.$*(0K1>)6

5/6789'8:;*$<*$=.).9>?8/.9'*$<*$>*9@.>?/.9'*P"*%)#)#/$'0("/$*%)#()/)#)#-$3#

&.)($--)#&.)'3%0?)#"--)(0"')#C$."/#0*4)./"+A$-#'3."*%$#"-#$%"&"-#')#(0(>)#'$#?0'"@#/"-#$-%"-#0*4)./"+A$-#*$($--0%"/#-$.#)5%0'"-#G0'$*%040("'"-#$#("&%"'"-H@#"--0/0>"'"-#G()*L$(0'"-@#>0'"-#$#()/1&.$$*'0'"-H@#()*-$.?"'"-#G".B30?"'"-#$#"%3">08"'"-#B3"*')#()..$-&)*'"/H#$#3%0>08"'"-#G40(".$/#'0-&)*2?$0-H6#9--)#.$B3$.#"# 0*%$.?$*+,)#'$# 0*'0?2'3)-#()/#)-# "'$B3"')-# ()*L$(0/$*%)-#%I(*0()-#$#')%"')-#'$#/$0)-#%I(*0()-6#

J#?$.'"'$#B3$#)-#/$0)-#%I(*0()-#*,)#-,)#0/&.$-(0*'2?$0-#&"."#"#C$-%,)#')#()*L$(0/$*%)@#/"-#3/"#5"-$#'$#'"')-#0*4)./"%08"'"#I#"#4)./"#/"0-#&.K%0("#'$# 4"8O1>)6#E).I/@#$/#/30%)-#("-)-#I#&)--2?$>#)3#.$()/$*'K?$>#()/$+".#'$# 4)./"#/"*3">@#()/#"# 40*">0'"'$#'$#"'B30.0.#"#$T&$.0O*(0"#*$($--K.0"#$#'$&)0-# 0*4)./"%08".#)# -0-%$/"#B3$#'$/)*-%.)3#"#-3"#$40(K(0"#&.K%0("67# 0/&>"*%"+,)#'$#3/# -0-%$/"#'$#

C$.$*(0"/$*%)#')#()*L$(0/$*%)#&)'$#'$-()/&).1-$#*"-# -$C30*%$-# "+A$-@#()/#'$/)*-%."#"#A?=&)8$2S

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

996#Y$-0C*"+,)#')#C$-%).S#"#&.0/$0."#%".$4"# '"# $B30&$# '$# %."5">L)# -$.K#"# *)/$"+,)# ')# 0*'0?2'3)# B3$# 0.K#C$.$*(0".#)#-0-%$/"6#U$#4).#&)--2?$>#*)/$".#')0-#&.)40--0)*"0-@#3/#.$-&)*1-K?$>#&.0*(0&">#$#3/#-3&>$*%$@#/30%)#/$>L).@#$/#%$./)-#'$#-$C3."*+"X9996#Y$40*0+,)#')-#("/&)-#'$#0*4).1

/"+,)#.$>$?"*%$-S#"#-$C3*'"#%".$4"#'"#$B30&$#'$#%."5">L)#-$.K#"#'$40*0+,)#&.$>0/0*".#')-#("/&)-#'$# 0*4)./"1+,)#.$>$?"*%$-#*)#C$.$*(0"/$*%)#')#()*L$(0/$*%)@#&).#$T$/&>)S# M%"&"#'$#()*($&+,)S#

#1 M-%"5$>$(0/$*%)#'"# 4D./3>"@#B3$#0*(>30S

#» :"."(%$.2-%0("-#')-#()/&)1*$*%$-#G42-0("-#$#B32/0("-HX

#» E.)&).+,)#')-#()/&)*$*%$-X

#» 9*%$."+A$-#$*%.$#)-#()/&)1

A?=&)8$2$B$5/6789'8:;*$<.$&/$C?C'./8$<.$=.).9>?8/.9'*$<*$>*9@.>?/.9'*

D*9>.6:;*

E)89CF.)G9>?8

H87?<8:;*

I)*<&:;*

J&C6.9C;*:0(>)#'$#?0'"#')#&.)'3%)

F.C"*08"+,)#'"#$B30&$'$#%."5">L)

!)/$"+,)#')#C$-%). Y$40*0+,)#')-#("/&)-#'$#0*4)./"+,)

Z$?0-,)#$#"%3">08"+,)

7.B30?)#'"-#0*4)./"+A$-#.$>$?"*%$-

:)>$%"#$#40>%."C$/

9*4)./"+A$-

Page 49: Revista Fármacos & Medicamentos (Edição 64)

!"#"$%&'()*+,+$-.+%'''/0.12.01'''0345-400

!"!#"$%&"$'()*%+"%,*!,"')-*%.*/0(1%*2%!-*34

%» 56#*+*$%+"%(!(17$"4

%» 8$#(9717+(+"

%: 8$#(9"1",70"!#*%+*%'/*,"$$*;%<2"%(9/(!=">

%» 8#('($%"%'*!#*$%,/?#7,*$%+"%,*!#/*1";

%» 8<27'(0"!#*$;

%» @7$#"0($%+"%,*!#/*1"A

% 8#('(%+"% #/(!$."/B!,7(>% C!,12$-*%+"%!*D*$%,*!E",70"!#*$%"%0*:+7.7,()-*;%<2(!+*%,*//"$'*!+(;%+*$%,*!E",70"!#*$%(+<27/7+*$%!(%"#('(%+"%,*!,"')-*A

% 8#('(%+"%D(17+()-*>

%: F"/7.7,()-*%+(%(+"<2()-*%+*$%,*!E",70"!#*$% (+<27/7+*$%!($%"#('($%+"%,*!,"')-*%"%+"%#/(!$."/B!,7(4

%: F"/7.7,()-*%+(%,('(,7+(+"%+"%,*!#/*1"%+*%'/*,"$$*%0*!7#*:/(!+*%*$%'*!#*$%,/?#7,*$4

%: F"/7.7,()-*%+(%,('(,7+(+"%+*%'/*,"$$*A

% 8#('(%+"%'/*+2)-*>

%: G"$21#(+*$%+*%0*!7#*/(0"!#*%+*%'/*,"$$*4

%: G"$21#(+*$% +*% ,*!#/*1"% +(%<2(17+(+"4

%: HD(17()-*%+*%'/*,"$$*% &$"=2:/(!)(%+(%<2(17+(+"34%

%: HD(17()-*%+*$%+"$D7*$;% /",1(:0()I"$%"%!-*%,*!.*/07+(+"$4

%: HD(17()-*%+(%"$#(9717+(+"A

% 8#('(%+"%$2$'"!$-*%+(%'/*+2)-*%*2%+"$,*!#7!2()-*%+(%,*0"/,7(:17J()-*>

%: HD(17()-*%+($%/",1(0()I"$4

%: HD(17()-*%+(%"$#(9717+(+"A

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

80%/"$20*>%% P0%0*+"/!*%$7$#"0(%+"%<2(17+(+"%$*0"!#"%#"/L%$"!#7+*%$"%7!,*/'*/(/%*%="/"!,7(0"!#*%+*%,*!E",70"!#*4

% Q/()($% (*% ="/"!,7(0"!#*% +*%,*!E",70"!#*% $-*%'*$$?D"7$%+":

Page 50: Revista Fármacos & Medicamentos (Edição 64)

G a r a n t i a e C o n t r o l e d a Q u a l i d a d e

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % 3 " 4 " ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % 3 " 4 " % % % 5 6

!"#$%#&'()#%)*)#' %+'!",-!")#' %'

!.+')/)0")12.'*.'-3/%0'*%'4"#!.5

' 6'.(7%8"/.'*.'9%4%-!")+%-8.'*.'

!.-:%!"+%-8.';'.'*%'<.##="4' >'

*"#<.#"12.'=+'()-!.'*%'*)*.#'

!.+' 8.*.#'.#'*)*.#'%')#' "-?.4@

+)1$%#'4%0%/)-8%#'4%!.0:"*)#').'

0.-9.'*%'8.*.'.'!"!0.'*%'/"*)'*%'

=+'<4.*=8.5

' 6'%A!%##.'*%' "-?.4+)12.';' 82.'

4="+'!.+.')' #=)'!)4,-!")&'<.4'

"##.';'-%!%##B4".'*%?"-"4'!)+<.#'

*%' "-?.4+)12.&'.'C=%'-2.'C=%4'

*"D%4'C=%'-2.'#%'<.##)' E%'*%/%F'

!.0%8)4@#%'"-?.4+)1$%#'4%0%/)-8%#'

-2.'!.+<4%%-*"*)#'-%#8%#'!)+<.#5

' G'!.0%8)'%')'?"084)9%+'*)#'"-?.4@

+)1$%#'9%4)*)#'-.#'*"#8"-8.#'*%@

<)48)+%-8.#'*=4)-8%')#'*"?%4%-8%#'

%8)<)#'*.'!"!0.'*%'/"*)'*.'<4.*=8.'

#2.' 4%)0"D)*)#' <%0.' 9%#8.4' E.='

9%#8.4%#F' *.' #"#8%+)&' -.+%)*.'

<.4'=+)'%C="<%'+=08"*"#!"<0"-)4'

E<.4' %A%+<0.&' .'+%#+.'C=%' ;'

4%#<.-#B/%0'<%0.'9%4%-!")+%-8.'

*)#'+=*)-1)#FH'I#8)#'"-?.4+)1$%#'

#2.' "-84.*=D"*)#' %+'=+'()-!.'

*%'*)*.#5

' J.44%#<.-*%' 8)+(;+').'9%#8.4'

)' 4%/"#2.' %' )' )8=)0"D)12.' *)#'

"-?.4+)1$%#'*.'()-!.'*%'*)*.#&'

#%'?.4'-%!%##B4".&'%+'?=-12.'*%'

-./.#'!.-:%!"+%-8.#'.='*%'+.@

*"?"!)12.'*.#'%A"#8%-8%#5

' 6'<)<%0'*.'9%#8.4';'!438"!.&'<.4'

"##.'*%/%'#%4'-.+%)*.'=+'<4.?"#@

#".-)0'!.+'?.4+)12.'%'%A<%4",-!")'

!.+<4./)*)5

' 6'#"#8%+)'*%/%'#%4'<4%?%4"/%0+%-@

8%&' "-?.4+)8"D)*.&'!.+' 4%!=4#.#'

)<4.<4")*.#'<)4)'8.4-)4')!%##3/%0'

)'8.*.#'.#'+%+(4.#'*)'%C="<%5

' 6'9%4%-!")+%-8.'*.'!.-:%!"+%-8.'

<.##="'#=)'()#%'-)'!.-!%<12.'*)'

?"-)0"*)*%'*.'<4.*=8.&'#%')+<0")'

!.+'.#'*)*.#'*.'*%#%-/.0/"+%-8.'

8%!-.0K9"!.'%'*.'<4.!%##.'<4.*=@

8"/.H'G0;+'*"##.&'!.+<.48)'*)*.#'

4%0)!".-)*.#'!.+')#'"-?.4+)1$%#'

)!%4!)'*%'*%#/".#'8;!-"!.#'%'*)#'

4%!0)+)1$%#' *%' !0"%-8%#' %' *%'

=#=B4".#H' I##%' ()-!.'*%'*)*.#'

<.*%' #%4' 8)+(;+' %+<4%9)*.'

-)'<4%#%4/)12.'%'-)'*"?=#2.'*%'

.=84)#' "-?.4+)1$%#&' !.+.'<.4'

%A%+<0.&' )#' *%4"/)*)#'*%' !.-@

94%##.#'.=')=0)#5

' 6'9%4%-!")+%-8.'*.'!.-:%!"+%-8.'

-2.'*%/%4")'#%4'=+'-./.'%#8.4/.'

-.' !)+"-:.' *)' #%9=4)-1)' *)'

C=)0"*)*%'.=&'%+'.=84)#'<)0)/4)#&'

+)"#'<)<%0H'L##.'-2.'8%4")'#%-8"*.'

)09=+H'6'#%=')0/.'/%4*)*%"4.';'

!.0%8)4'%'<4%#%4/)4')#'"-?.4+)1$%#'

M8%"#'<)4)')'%+<4%#)5

' N.*)'"+<0)-8)12.'*%')09.'-./.'9%4)'

*M/"*)#'%'<4.(0%+)#'*%'4%0)!".-)+%-8.'

.49)-"D)!".-)0'%'.'9%4%-!")+%-8.'

*.'!.-:%!"+%-8.'-2.'<.*%4")'#%4'

=+)'%A!%12.H !/////)

!"#$%&'"()(&;'94)*=)*.'%+'?)4+B!")'%'(".0.9")&'!.+'*.=8.4)*.'%+'?)4+B!")'<%0)'O-"/%4#"*)*%'*%'P)4!%0.-)'EI#<)-:)FH'G8=)0+%-8%';'!.-#=08.4'*)'"-*M#84")'

?)4+)!,=8"!)'%+')##=-8.#'*%')!.-#%0:)+%-8.&'C=)0"*)*%&'/)0"*)12.5')!)*,+"!.'

:.-.4B4".'*)'G!)*%+")'*%'Q)4+B!")'*.'P4)#"0'%'+%+(4.'*)#')##.!")1$%#'!"%-@

83?"!)#'N:%'R:)4+)!%=8"!)0' )-*'S%)08:!)4%'T!"%-!%#'T.!"%8U&'R)4%-8%4)0'V4=9'

G*+"-"#84)8".-'ERVGF&'G*/%4#%'I/%-8#'Q.00.W"-9'L++=-"D)8".-'EGIQLF'%'XYZ.4*"!H

*+,#"&-.&/"#)(("';'94)*=)*.'%+'94)*=)*.'%+'?)4+B!")'%'(".C=3+"!)&'+%#84%'%+'8%!-.0.9")'C=3+"!.@?)4+)!,=8"!)'%'*.=8.4'%+'!",-!")'*.#')0"+%-8.#'<%0)'Q)!=0*)*%'

*%'J",-!")#'Q)4+)!,=8"!)#'*)'O-"/%4#"*)*%'*%'T2.'R)=0.'EQTQ[OTRFH'G8=)0+%-8%'

;'<4.?%##.4'!.0)(.4)*.4'*%'#=<%4/"#2.'%'9)4)-8")'*)'C=)0"*)*%'*)'Q)!=0*)*%'*%'

J",-!")#'Q)4+)!,=8"!)#'*)'O-"/%4#"*)*%'*%'T2.'R)=0.'EQJQ@OTRF&'/"!%@<4%#"*%-8%'

%A%!=8"/.'*.'T"-*"!)8.'*)'L-*M#84")'*%'R4.*=8.#'Q)4+)!,=8"!.#'-.'I#8)*.'*%'T2.'

R)=0.'ETLZVOTQGX\GF'%'#%!4%8B4".'9%4)0'*)'G!)*%+")'Z)!".-)0'*%'Q)4+B!")H

' OT'QVGH'R:)4+)!%=8"!)0'J]\RT'

?.4'8:%'^_#8'!%-8=4U'@'G'4"#`@()#%*'

)<<4.)!:H' Q"-)0' 4%<.48H' ^aabH'

E:88<c[[WWWH?*)H9./FH

' LJSH'R:)4+)!%=8"!)0' *%/%0.<@

+%-8H'LJS'S)4+.-"#%*'N4"<)48"8%'

]="*%0"-%H'deH' ^aafH' E:88<c[[

WWWH"!:H.49FH

' LJSH'd=)0"8U'4"#`'+)-)9%+%-8H'

LJS'S)4+.-"#%*'N4"<)48"8%']="@

!"#"$%&'()*+,(-.(/0$1#(')*

*%0"-%H'dgH'^aafH'E:88<c[[WWWH

"!:H.49FH

' LJSH'R:)4+)!%=8"!)0'C=)0"8U'#U#@

8%+H'LJS'S)4+.-"#%*'N4"<)48"8%'

]="*%0"-%H'd_aH'^aaeH' E:88<c[[

WWWH"!:H.49FH

' OT' QVGH'd=)0"8U' TU#8%+#'G<@

<4.)!:'8.'R:)4+)!%=8"!)0'J]\R'

X%9=0)8".-#H']="*)-!%'?.4'L-*=#@

84UH'^aahH'E:88<c[[WWWH?*)H9./FH

Page 51: Revista Fármacos & Medicamentos (Edição 64)
Page 52: Revista Fármacos & Medicamentos (Edição 64)

T e r c e i r i z a ç ã o

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % " 3 4 3 ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % " 3 4 3 % % % ! 5

! 6(*+7'89+!"#$%&'(%()"(*+",-*($.*+"/%-0%12$3

.'1*+" .)0"%&1%45%(*"467)'+")&)7%(*+"4*+"8&.'0*+"%4*+9":*4.-';$6-%0",%-%"'++*"*+"8&.'0*+"%7%45*+"4%+".<14'1%+"()"%4=&'+)"(*+"/=-0%1*+")"(*+",-*($.*+>"*+" )#$',%0)4.*+" )" +$%+" '4*7%5?)+".)14*&@A'1%+>" %" '0,&)0)4.%5B*" ()"1*4.-*&)+" 4*" ,-*1)++*>" %"0)&C*-'%"(%" #$%&'(%()" (*+" /*-4)1)(*-)+>" *+"'0,*-.%4.)+"%7%45*+"(%+"4*-0%.'7%+"-)A$&%.@-'%+>"4*+"#$%'+"%"!A241'%"D%31'*4%&"()"E'A'&F41'%"G%4'.=-'%"H!DEIG!J")+.="'4+)-'(%>")4.-)"*$.-*+")&)0)4.*+9"!,)+%-"(%"0)&C*-'%"4%"#$%&'(%()")"

(*" 1*4C)1'0)4.*" .<14'1*31')4.6/'1*")K)-1'(*+" +*;-)"*+" I4+$0*+" L%-0%312$.'1*+"!.'7*+"HIL!J>"4B*"C="4*-0%+")+,)16/'1%+"()"M*%+"N-=.'1%+"()" L%3;-'1%5B*" HMNLJ" ,%-%" *+" )K1',')4.)+"$.'&'O%(*+"4*+",-*($.*+"/%-0%12$.'1*+9":*0"*" %7%45*" (*" 1*4C)1'0)4.*"

1')4.6/'1*" +*;-)"*+",-*1)++*+" /%-0%312$.'1*+>"<"1%(%"7)O"0%'+"4)1)++=-'*"%0,&'%-"*"1*4C)1'0)4.*"+*;-)",-*($.*+")",-*1)++*+>"()+()"*"()+)47*&7'0)4.*"

!"#$%#%&'&()#%*#%+#(,-+.$-(/#%+.-(/01.+#%2#34-%#2%54#+-22#2%1&4$&+67/.+#28%9%+&*&%'-:%$&.2%(-+-22;4.#%&$5<.&4%#%+#(,-+.$-(/#%2#34-%54#*7/#2%-%54#+-22#28%*-2*-%#%*-2-('#<'.$-(/#%1&4$&+#/9+(.+#%-8%(-2/-%+#(/-=/#8%#2%-=+.5.-(/-2%-2/>#%2-(*#%$&.2%-%$&.2%.(2-4.*#2%-%&'&<.&*#2%+#$#%/-(*#%.$5#4/?(+.&%-%.$5&+/#%(&%@7&<.*&*-%2-$-<,&(/-2%&#%ABCDE

Circular para:

:;

:&<=

>;

=?&1

:&<

@@

A::A:

=B1

C?D>

!"#$%&'()*+,-$.,/0)*#*1(&1.,#+%+,+,23+4*-+-1,-$.,5%$-3&$.,6+%"+)73&*)$.EFG*%:FHGI(+

Page 53: Revista Fármacos & Medicamentos (Edição 64)
Page 54: Revista Fármacos & Medicamentos (Edição 64)

T e r c e i r i z a ç ã o

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # " $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ 2 3 4 3

!"#$"%&'(%)*%&+,-+),.',+%&)',/'&-+&.+,/%*0*,)',.+,.'1&+.,)2&+$"*.+,+$"*.+*).,#*2&.+ ,+ "3"4*"2&.+ %&$&+ ',)2&+*$0&#'5)%*"+,+*$0"%'&+)"+67"4*2"2,+.,$,48")',.+"&+9:;<+

567898.:'.;<$9=;;=>*=$>&#"+.,$0#,+',)8"$+.*2&+%&)?

.*2,#"2".+ .7>.'5)%*".+ *),#',.+ ,$+7$"+ !&#$74"@1&+ !"#$"%A7'*%"-+ &.+,/%*0*,)',.+0&..7,$+0"0,4+#,4,3")',+)&+2,.,$0,)8&+2&.+$,2*%"$,)'&.<+B.+$&'*3&.+ 0,4&.+ 67"*.+ "&.+ ,/%*?0*,)',.+ ',)8"+ .*2&+ "'#*>7C2"+ 7$"+*$0&#'5)%*"+#,4"'*3"-+,/04*%"?.,+0&#D

+ E,)&'"3"?.,+*$0&#'5)%*"+#,4"'*3"+"&+ 9:;+ F;G9H+ ,+67".,+),)87$"+"&.+,/%*0*,)',.I+

+ G&7%&.+ %#*'(#*&.+ 2,+ 67"4*2"2,+0"#"+&.+,.'72&.+2,+,.'">*4*2"2,I

+ G&7%"+ ',%)&4&J*"+ "04*%"2"+ K.+

")L4*.,.+2,+M&)'#&4,+2,+N7"4*2"2,I

+ G&7%&+%&)8,%*$,)'&+%*,)'C!*%&+.&>#,+*).7$&.+!"#$"%A7'*%&.D

+? N7"4*!*%"@1&+2,+!&#),%,2&#,.I

+? M"#"%',#*O"@1&+2&.+ !L#$"%&.+,+,/%*0*,)',.I

+? 9$07#,O".-+0#&%,..&.-+,.0,%*?!*%"@P,.-+$,'&2&4&J*".<

+ Q,4"@1&+ *)2R.'#*" S!&#),%,2&#+0&7%&+2,.,)3&43*2"I

+ G&7%"+*)',#!,#A)%*"+2"+*)2R.'#*"+)"+2,',#$*)"@1&+2,+,.0,%*!*%"@P,.+2&.+,/%*0*,)',.<+

?=;.$>.$')=:;8@A*G"74"'*)"$,)',+ &+ %&)8,%*$,)'&+

%*,)'C!*%&+0"..&7+"+*)',#!,#*#+)"+0,#?%,0@1&+2"+67"4*2"2,+2&.+,/%*0*,)',.+,+ )"+ #,4"@1&+ %&$+"+ 67"4*2"2,+ 2&+$,2*%"$,)'&<+G&#($-+)1&+!&*+7$+!"'&+*.&4"2&-+$".+&+%&)T7)'&+2"+,3&47@1&+

'(%)*%&?#,J74"'U#*"+%&$+"+',%)&4&J*"+,+&+%&)8,%*$,)'&+%*,)'C!*%&+67,+0#&?0*%*"#"$+&+ *)C%*&+2&+,)',)2*$,)'&+.&>#,+".+),%,..*2"2,.+2,+.,+"04*%"#+%&)8,%*$,)'&.+%*,)'C!*%&.+,+%&)'#&4,.+.&>#,+&.+,/%*0*,)',.<V,.',+.,)'*2&-+&.+0#&%,..&.-+".+)&#?

$".-+&.+,67*0"$,)'&.+,+".+'(%)*%".+%&)'*)7"#"$+"+,3&47*#-+0&..*>*4*'")2&+67,+'"$>($+&.+,/%*0*,)',.+.,+>,),?!*%*"..,$+2".+',%)&4&J*".+2*.0&)C3,*.<+B.+.,J7*)',.+,4,$,)'&.+0&2,$+.,#+%&).*2,#"2&.+2,)'#&+2,.',+0"*),4+2,+'#").*@1&+,)'#,+0".."2&+,+0#,.,)',D

+ W"*.+ A)!".,+ )"+ 67"4*2"2,+ 2&+0#&27'&+!"#$"%A7'*%&+,+2,+.,7.+*).7$&.I+

+ 9)3,.'*J"@1&+2,+2,.3*&.+2,+67"?4*2"2,+ 2,+ 0#&27'&+ ,+ "3"4*"@1&+2"+ *)',#!,#A)%*"+2&.+,/%*0*,)',.+%&$&+!"'&+%"7."2&#I

XG"74"'*)"$,)',+&+%&)8,%*$,)'&+%*,)'C!*%&+0"..&7+"+*)',#!,#*#+)"+0,#%,0@1&+2"+67"4*2"2,+2&.+,/%*0*,)',.+,+)"+#,4"@1&+%&$+"+67"4*2"2,+2&+$,2*%"$,)'&<+G&#($-+)1&+!&*+7$+!"'&+*.&4"2&-+$".+&+%&)T7)'&+2"+,3&47@1&+'(%)*%&?#,J74"'U#*"+%&$+"+',%)&4&J*"+,+&+%&)8,%*$,)'&+%*,)'C!*%&+67,+0#&0*%*"#"$+&+*)C%*&+2&+,)',)2*$,)'&+.&>#,+".+),%,..*2"2,.+2,+.,+"04*%"#+%&)8,%*$,)'&.+%*,)'C!*%&.+,+%&)'#&4,.+.&>#,+&.+,/%*0*,)',.<Y

Page 55: Revista Fármacos & Medicamentos (Edição 64)

!"#$%&'#$()*#+,&$-)$!"#$%&&#&'(%')"*&$#&'*&&+!,-$#&./)01#+2)0$(%'(#&*.%/'*,"*0+&'(%'&-&,%/*',%/!#'!"%&&1#'$#/'2334'567'8$#9,"#:%'%/'!"#$%&&#;

!"#$%&'"()*+*,%)-%.%/012)*+*3045067'8#045093)&:'(;"#%0<

345678$9:3!4$;<#*"#$9"=>$?$@A<BC=D0A<$>#EEF$9)*"#%G$?$BBBH&;1D"#/(*&I;/;<#*"#HA&"

$<<<=#!,-/*>?"*=$#/

4*&A)00#")%1&$-)$EJKID-&0$)$ED&LDEDM#+,&$-)$0I=01N%AD#0

7*".*@A%&$*".*$#I1&"O1DA#$ :-#)-:-B*C1#$$$$D%$9#:#.-*'(%'5&#:*(#"%&$;#*#$"OPD"#$!"#,%C1#'(#'!"#(E,#

!"#$"%&'()*(+),-%"$).*&'/0#"1'-2//3456475($$/8&#*/9''1)(.&:)$;)#<-.,,(((4 4=<44<3545(((47>4=>4?

! "#$%&!&'$()*+,&#%-!

! .')/%&#*! +'01%),$#0*!1*! #2'1+#34#0*56%!'!*17)#8'9!%(!8':*9!;*#8!'<(#=*;'1+%8-

! .')/%&'8!'!0%1/'0#;'1+%!;*#8!0%18#8+'1+'8!8%>&'!'8+*>#)#2*2'-!

! .*#8!0%1/'0#;'1+%!8%>&'!#18(;%8!4*&;*0?(+#0%8!*+#@%8-

! A;=%&+B10#*!2*!<(*)#4#0*56%!2%8!4%&1'0'2%&'8!1%!=&%0'88%!2'!2'4#1#356%!2*!<(*)#2*2'!2%!;'2#0*;'1+%-

! .*#8!0&#+C&#%!'!0'&+'D*!1*!2'+'&3;#1*56%!2'!'8='0#4#0*5E'8-!

! F'+'&;#1*56%!2'!=*&B;'+&%8!0&G3+#0%8!1%8!#18(;%8!4*&;*0?(+#0%8H!

!"#$%&'()*+,-$.,/0)*#*/(&/.,(+,+&1+2*-+-/I8!'J0#=#'1+'8!=%2';!*+(*&!0%;%!

')';'1+%8!0*&&'*2%&'8!2%8!AKL9!4*0#3

)#+*2%&'8!2*!*>8%&56%9!;%2#4#0*2%&'8!

2%!8*>%&9!4*0#)#+*2%&'8!2*!2'$)(+#56%9!

='&;#+#12%!*!*=)#0*56%!2*!(1#2*2'!

=%8%),$#0*9!'1+&'!%8!;*#8!#;=%&+*1+'8H

M%&;*);'1+'! %8! 'J0#=#'1+'8! 2'!

(;*! 4%&;()*56%! 86%! =)*1':*2%8!

=*&*! 16%! #1+'&*$#&! 1%! %&$*1#8;%!

=&%@%0*12%!'4'#+%8! 4*&;*0%),$#0%8!

%(! *=&'8'1+*12%! '4'#+%8! *2@'&8%8H!

N'!16%!'8+#@'&';!>';!'8+(2*2%8!'!

*@*)#*2%8! 1%! 2'8'1@%)@#;'1+%! 2%!

=&%2(+%9!=%2';!#1+'&*$#&!0%;!%!AKL!

O47&;*0%P9! 0%;!%(+&%8! 'J0#=#'1+'8!

'! 0%;! *! ';>*)*$';! =&%@%0*12%!

'@'1+%8! 16%! '8='&*2%8! 2(&*1+'! %!

=&%0'88*;'1+%!'!*!*&;*D'1*$';H!

L88#;9!'J'&0';!*+(*56%!#;=%&+*1+'!

1*! <(*)#2*2'! 2%!;'2#0*;'1+%! '9!

0*8%! 16%! /*:*! %! 2'@#2%! 0%1+&%)'9!

=%2';!0%;=&%;'+'&!*!'4#070#*!2%!

47&;*0%9! )'@*12%! *! #1+'&4'&?10#*8!

8%>&'!*!<(*)#2*2'9!*!8'$(&*15*!'!*!

'4#070#*!2%!;'2#0*;'1+%H!

Q1+&'!%8!=&#10#=*#8!=&%>)';*8!=%+'13

0#*#8!';!=&%2(+%8!4*&;*0?(+#0%89!<('!

=%2';!+'&!*+(*56%!%(!#1+'&4'&?10#*!

2%8!'J0#=#'1+'89!0#+*38'R

! S#%2#8=%1#>#)#2*2'!2%! 47&;*0%R!

T*;*1/%9!=%&%8#2*2'!2*8!=*&+G3

0()*8!%(!4%&;*+%!2%8!0&#8+*#8!2%!

'J0#=#'1+'! =%2';! #1+'&4'&#&! 1*!

)#>'&*56%!2%! 47&;*0%!*4'+*12%!

*88#;!*!>#%2#8=%1#>#)#2*2'-!

! U&%2(+%8!2'!2'$&*2*56%R!N(>;'3

+#2%8!V8!'+*=*8!2%!=&%0'88%!'!2%!

*&;*D'1*;'1+%9!%8!'J0#=#'1+'8!

#1*2'<(*2%8!=%2';!&'*$#&!0%;!%8!

#18(;%8!*+#@%8!'!%8!;*+'&#*#8!2'!

';>*)*$';!=&%2(D#12%!=&%2(+%8!

2'!2'$&*2*56%!<('!=%2';!#1+'&4'&#&!

1*!'8+*>#)#2*2'!2%!=&%2(+%!'!)'@*&!

*!'4'#+%8!+,J#0%8!1%8!=*0#'1+'8-

Page 56: Revista Fármacos & Medicamentos (Edição 64)

T e r c e i r i z a ç ã o

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( " # $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ 2 3 4 3 ! " # $ % & ' (!) * + , & % $ * - . ' ( " # $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ 2 3 4 3 $ $ $ ! 5

! "#$%&'()*+!,&-.'/0'/1'*!2-*!$&-34'**-*!2'!*5/1'*'!-%!2'!*-6.'/1'*!&'*02%)0*7! )*! 0#$%&'()*!$-2'#!1)#89#!0/1'&:'&0&!/)!'*1)80602)2'!'!/)!1-;0402)2'!2-!$&-2%1-<!

! =)6>)*! '! 2'*.0-*! 2'! ?%)602)2'!2-!$&-2%1-+!@*!';40$0'/1'*!4-#!'*$'40:04)AB'*! 0/4-&&'1)*7! 4-#!4-/1)#0/)/1'*!'!4-#!0#$%&'()*!$-2'#!):'1)&! )*!'*$'40:04)AB'*!2-!$&-2%1-!:0/)6!C2%&'()7!:&0)806032)2'7!2'*0/1'D&)AE-7!D&)/%6)AE-7!*-6%80602)2'7!1%&.)AE-7!.0*4-*02)2'!'14FG!-%!$&-.-4)&!0/1'&:'&H/40)*!/)!'*1)80602)2'! C4-&7! 4&0*1)60()AE-7!4-)D%6)AE-7!$&'40$01)AE-!'14FG

! ,'&:06!2'!20**-6%AE-!2-!$&-2%1-+!I! :-&#%6)AE-! 2'! *J602-*! -&)0*!$-2'! *'&!):'1)2)!$'6-! 1)#)/>-!'!:-&#)*!2)*!$)&154%6)*!2-!';403$0'/1'!)61'&)/2-!)!)D6%10/)AE-!'!)!4-#$)41)AE-!2-!4-#$&0#02-!&'*%61)/2-!/)!#-20:04)AE-!2-!$'&:06!2'!20**-6%AE-!2-!0/*%#-!)10.-F

I! ?%)602)2'! 2-*! ';40$0'/1'*! /-!K#801-!2)!?%)602)2'!2-!$&-4'**-!'!2-!$&-2%1-!'7!)0/2)7!4-/:-&#'!)*!/-&#)*!)1%)0*7!*'!&'6)40-/)!'!0#$)41)!4-#+

! L*1%2-*!2'!'*1)80602)2'<!

! M0-20*$-/080602)2'<!

! L?%0.)6H/40)!:)&#)4H%104)<!

! L*1%2-*!2'!$&93:-&#%6)AE-<!

! "#$%&'()*!'!$&-2%1-*!2'!2'D&)32)AE-<

! N)&)41'&0()AE-!2-*! :O&#)4-*! '!';40$0'/1'*<

! "#$&'*40/25.'6!?%)60:04)AE-!2-*!:-&/'4'2-&'*<!

! P'1'&#0/)AE-Q).)60)AE-!4-&&'1)*!2)*!'*$'40:04)AB'*<!!

! P'1'&#0/)AE-!2-*!I1&08%1-*!N&53104-*!2'!R%)602)2'!CINRG<

! S'&'/40)#'/1-!2-!&0*4-!/)!?%)3602)2'F!

L*1'*!#-2'&/-*!'6'#'/1-*!2'!'*1)38'6'40#'/1-!'!2'!)$&0#-&)#'/1-!2)!?%)602)2'!2'!%#!$&-2%1-!:)&#)4H%104-!*'!)$604)#!1)#89#!)-*!';40$0'/1'*F!T-!2'*'/.-6.0#'/1-!2-!$&-2%1-!:)&3

#)4H%104-7!)69#!2-!'*1)8'6'40#'/1-!2-!0/*%#-!:)&#)4H%104-!)10.-!'!)!2':0/0AE-!2)*!'1)$)*!4&0104)*!2-!$&-4'**-7!)!2'1'&3

#0/)AE-!2)!?%)602)2'!2-*!';40$0'/1'*!9!2'!:%/2)#'/1)6!0#$-&1K/40)!$)&)!)!2':0/0AE-!2)!?%)602)2'!2-!$&-2%1-!:0/)6F!

,*-*6$7*89.7:/.8'*6T'*1)!/-.)!'&)!2-!4-/>'40#'/1-7!

)*! 0/-.)AB'*! 194/04)*! )4-/1'4'#!#%01-! &)$02)#'/1'7! '*1)8'6'4'/2-!$)&K#'1&-*! ?%'7! )/1'*7! -%! '&)#!2'*4-/>'402-*!-%!/E-!$-2'&0)#!*'&!0/.'*10D)2-*!'!2'1'&#0/)2-*!2'.02-!U!0/';0*1H/40)!2'!1'4/-6-D0)F,)&)!-!:-&#%6)2-&7!/E-!8)*1)!)$'/)*!

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

).)60)AE-!2)!?%)602)2'!'!2)!)$604)AE-!2-*!0/*%#-*!'!4-/1&08%'#!$)&)!D)&)/10&!-!2'*'#$'/>-!2-!$&-2%1-!:)&#)4H%104-F

;/<*)'=87:>$?>$@&>A:B:7>CD*$?.$B*)8.7.?*).6$I! ?%)60:04)AE-! 2'! :-&/'4'2-&'*!

D)/>)!0#$-&1K/40)!#%610$604)2)!'#!.0&1%2'!2)!4-#$6';02)2'!2)*!-$'3&)AB'*! 2)*! '#$&'*)*! '! 2-*! /-.-*!:)8&04)/1'*!#%/20)0*! 2'! 0/*%#-*F!,-**080601)!U*!0/2X*1&0)*!:)&#)4H%104)*!4-/>'4'&'#!-*! 0/*%#-*!$&'*'/1'*!/-*! $&-4'**-*! 2'! :)8&04)AE-7! -*!:)8&04)/1'*!'!-*!:-&/'4'2-&'*7!$-*3*080601)/2-! )! *'D%&)/A)!/'4'**O&0)!$)&)!)!)?%0*0AE-!'!%*-!2'!0/*%#-*!'#!*'%*!$&-2%1-*F!Y'**)61)3*'! ?%'! -! :)8&04)/1'! 2-!

$&-2%1-!:)&#)4H%104-!&'*$-/2'!$'6-!$&-2%1-! :0/)6!'!$'6-*!';40$0'/1'*!'!:O&#)4-*!?%'!4-6-4)!'#!*'%!$&-2%1-F!!I69#!2'!*'&.0&!$)&)!4-/:0&#)&!)*!

'*$'40:04)AB'*!'!-*!I1&08%1-*!N&5104-*!2'!R%)602)2'!CINRG7!)/1'&0-&#'/1'!2'1'&#0/)2)*7! )! ?%)60:04)AE-! 2'!:-&/'4'2-&'*! 2'! "=I! '! ';40$0'/1'*!9!&'6'.)/1'7!1)#89#7!$)&)!$&'.'/0&!)! '/1&)2)! 2'!#)1'&0)0*! 0/4-&&'1-*!/-! *0*1'#)7! 4-/:-&#'! )! E:F&)>$ 2!2'#-/*1&)F

E:F&)>$2$ G$H)IB:7*$?./*86')>8?*$>$ ).A.-=87:>$ ?>$ @&>A:B:7>CD*$ ?.$B*)8.7.?*).6

E:F&)>$4$G$EA&J*F)>/>$?./*86')>8?*$@&.$>$6.F&)>8C>$?*$<>7:.8'.$'>/(K/$6.$).A>7:*8>$7*/$.6<.7:B:7>CL.6$?.$.J7:<:.8'.6

M6<.7:B:7>CD*MJ7:<:.8'.6

NOP6MJ7:<:.8'.6

P+Q+MR)*?&'*

R>7:.8'.

E*)8.7.?*)P&>A:B:7>?*$

MA:/:8>)S:8:/:1>)T.?&1:)R).-.8:)

;/<&).1>6$E>A6:B:7>CD*$$SI$P&>A:?>?.$M))*6$0.B.:'*6$M6'>(:A:?>?.

R%0

%$PUM

Page 57: Revista Fármacos & Medicamentos (Edição 64)
Page 58: Revista Fármacos & Medicamentos (Edição 64)

T e r c e i r i z a ç ã o

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % 3 4 5 4 ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % 3 4 5 4 % % % ! 6

708+*(9:;<=%>+?%@(*<)'(+?%A*B(<;+?%

>/%C'=D<>=>/%E@ACF%

!"#$%#&%'%()*+,(#,$#%$-%.*/*.,01%$#&"$#%2.*-*%+'%$3#&%4%5$%#%$',6%7%.%(#"$#!'(*68'"$#9(:'*."$#&%#;8,7*&,&%#<!9;=>#!9;#$?"#-("-(*%&,&%$#/:$*.,$3#@8:)*.,$3#6*"7AB*.,$#"8#)*.("6*"7AB*.,$#"8#.,(,.'%(:$'*.,$#@8%#&%4%)#-"$$8*(#8)# 7*)*'%# &%# ."+'("7%# ,-("-(*,&"3#/,*2,$#"8#&*$'(*68*0?"#-,(,#,$$%B8(,(#,# @8,7*&,&%#&%$%C,&,#&"#-("&8'">#!9;# $?"3# B%(,7)%+'%3# ,$$".*,&"$#.")#$86$'D+.*,$#,'*4,$3#%2.*-*%+'%$3#*+'%()%&*E(*"$#%#-("&8'"$#/*+,*$>#F2%)-7"$#&%#!9;#-,(,#$86$'D+.*,$#

,'*4,$# "8# *+'%()%&*E(*"$G# &*$'(*68*50?"# %# ',),+H"#&%#-,(':.87,$3# -I3#-"("$*&,&%3# '*-"# &%# .(*$',73# %+'(%#"8'("$>#;8,+&"#+?"#&%'%()*+,&"$#%# ."+'("7,&"$3# -"&%)# *+'%(/%(*(# %#,/%',(#,#."+'*+8*&,&%#&"#-(".%$$"#"8#*+/78%+.*,(#&*(%',)%+'%#+"#&%$%)-%5+H"#%#+,#@8,7*&,&%#&"#)%&*.,)%+'">#!9;# &"$# -("&8'"$# *+.78%)# ,$#

-("-(*%&,&%$#@8%#."+.%&%)#,#@8,7*5&,&%3#,#$%B8(,+0,#%#,#%/*.E.*,#&%$%5C,&,$>#J,(,#$A7*&"$#"(,*$#$?"#,@8%7%$#,$-%.'"$# @8%# ,/%',)# ,# -8(%K,# &"#

-("&8'"3#,#-"'L+.*,3#,#%$',6*7*&,&%#%#,#7*6%(,0?"#&"#/E(),.">#!9;#-,(,#"8'("$#$*$'%),$#&%#7*6%(,0?"#-"&%)3#,&*.*"+,7)%+'%3# *+.78*(# ,$-%.'"$#%$-%.:/*."$#&"#-("&8'"3# ',*$# .")"#-("-(*%&,&%$# ,%("&*+D)*.,$# -,(,#-("&8'"$#*+,7,&"$3#%$'%(*7*&,&%#-,(,#-,(%+'%(,*$#%#/"(0,#,&%$*4,#-,(,#"$#!"#$%&'#'(,+$&M()*."$>N$#!9;#&"#-("&8'"#$?"#8'*7*K,&"$#

-,(,# B8*,(# "# &%$%+4"74*)%+'"# &"#-("&8'"#%#&"#-(".%$$">#!#7*$',#&"$#!9;#-"'%+.*,*$#-"&%#$%(#)"&*/*.,5&,#$%#,# /"()87,0?"3#"#-(".%$$"#&%#/,6(*.,0?"#%#"#-("&8'"#/"(%)#),*$#."+H%.*&"$>#!9;#(%7%4,+'%$#-"&%)#$%(# *&%+5

'*/*.,&"$#-"(#8)#-(".%$$"#*+'%(,'*4"#&%#B%(%+.*,)%+'"#&"#(*$."#&,#@8,57*&,&%#%#%2-%(*)%+',0?"#@8%#/*2,)#,#,)-7*'8&%3#.8C,$#4,(*,01%$#-"&%)#,-(%$%+',(#*)-,.'"#$"6(%#,#@8,7*&,&%#&"#-("&8'">

708+*(9:;<=%>=%8*GHI+*0'D=JK+%

!#-(M5/"()87,0?"#M#8),#'(*,B%)3#8),#-(M4*,# &"# %$'8&"#&%# %$',6*7*5&,&%3#+,#@8,7#,#,-7*.,0?"#&%#'%$'%$#

)87'*4,(*,&"$# .")#"# /E(),."#%#"$#%2.*-*%+'%$#%)#."+&*01%$#,)6*%+',*$#&%#%$'(%$$%#-"&%#*&%+'*/*.,(#%4%+'8,*$#*+.")-,'*6*7*&,&%$>N#%$'8&"#&%#-(M5/"()87,0?"#%$',5

6%7%.%#8),#),'(*K#&%#,7B8+$#'%$'%$#-(M4*"$#%+'(%#"$#%2.*-*%+'%$#-("4E4%*$#%#%+'(%#"# /E(),."#%#"$#%2.*-*%+'%$#-("4E4%*$# -,(,# 4%(*/*.,(# ,# %$',6*7*5&,&%# &,$#)*$'8(,$3# ,# &%B(,&,0?"3#,# .")-,'*6*7*&,&%#&"$#%2.*-*%+'%$>#N$#'%$'%$#-(M4*"$#$?"#$86)%'*&"$#,#."+&*01%$# ,)6*%+',*$# ."+'("7,&,$#%# "$# (%$87',&"$#&,$# *+'%(,01%$# 4%5(*/*.,&"$>#!$# ."+&*01%$# &"$# '%$'%$#-"&%)#$%(G# '%)-%(,'8(,3#8)*&,&%3#"2*BL+*"3#)%',*$3#78K3#-I>!$$*)3# 8)# (*B"("$"# %$'8&"# &%#

-(M5/"()87,0?"#%#"#%$',6%7%.*)%+'"#,&%@8,&"# %# ."+'("7%# &,$# %$-%.*5/*.,01%$# &"$# %2.*-*%+'%$# 7%4,)# O#-(%4%+0?"# &%# -("67%),$# /8'8("$3#%7*)*+,+&"5$%#-"$$:4%*$#*+'%(,01%$#%#(%,01%$#&%#%2.*-*%+'%$#.")#*+$8)"$#,'*4"$#%#%)6,7,B%+$#%#)*+*)*K,0?"#&%#-("67%),$#&%#@8,7*&,&%#&"#-("5&8'"#/,(),.L8'*.">#

A=*=;(/*<2=JK+%>+?%

IL*0=;+?%/%/M;<8</:(/?%

!# .,(,.'%(*K,0?"# &%# /E(),."$#%# %2.*-*%+'%$# M# 8),# ,6"(&,B%)#+"4,3# @8%# 8'*7*K,# ,7',# '%.+"7"B*,#-,(,#,#&%'%()*+,0?"#&%#-,(D)%'("$#.*%+':/*."$#@8%#,'M#"#)")%+'"#+?"#'L)#$*&"#."+'("7,&"$#+,#("'*+,#&"$#7,6"(,'A(*"$# &%# ."+'("7%# &%# @8,7*5&,&%#&,$# *+&P$'(*,$# /,(),.L8'*.,$>#J,(,#)8*'"$#/E(),."$#%#%2.*-*%+'%$3#.%('"$#,'(*68'"$#-"&%)#.,8$,(#/"('%#*)-,.'"#$"6(%#,#@8,7*&,&%#&"#-("5.%$$"#/,(),.L8'*."#%#&"#-("&8'">!-%$,(#&%#+%)#'"&,$#%$',$#'%.+"7"5

B*,$#$%(%)#,6$"78',)%+'%#+"4,$3#,$#),*$#+"4,$#,*+&,#%$'?"#%)#&%$%+4"754*)%+'"3#),$#/,.%#O$#.")-7%2*&,&%$#%#+%.%$$*&,&%$#'M.+*.,$3#'%+&%(?"#,#$%# '"(+,(# ("'*+%*(,$#+,#@8,7*/*.,0?"#&"$#%2.*-*%+'%$#%#/E(),."$>#!7B8+$#%2%)-7"$#&%$',$#+"4,$# '%.+"7"B*,$#%#$8,#,-7*.,0?"G

# Q,),+H"# %# /"(),#&"$# .(*$',*$G#$"786*7*&,&%3#RST#

Page 59: Revista Fármacos & Medicamentos (Edição 64)
Page 60: Revista Fármacos & Medicamentos (Edição 64)

T e r c e i r i z a ç ã o

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( ! # $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ 2 " 3 " ! " # $ % & ' (!) * + , & % $ * - . ' ( ! # $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ 2 " 3 " $ $ $ 4 5

!"#$%&"'#()*!"!#$%&'%&(!)*!+%$*,-.%!)!/.(0'1*.-%!2)3%!4%-'3&%&)!&)!5.678-.%9!4%$*%-7':.-%9!&%!;8.<)$9.&%&)!&)!=>(!?%'3(!@4546;=?AB!#$%&'%&(!)*!%&*.8.9:$%C>(! .8&'9:$.%3!2)3%!4'8&%C>(!D%8E(3.8.!&%!4%-'3&%&)!?(3.:"-8.-%!@?FGHA!&%!;=?!)!2(99'.!I%9:)$!J'9.8)99!K&*.8.9:$%:.(8!@IJKA!2)3%!4LDM!K:'6%3*)8:)!"!#)$)8:)!&)!/(%9!2$,:.-%9!)!%'&.:($.%9!+%$*%-7':.-%9!&(!=.8&.-%:(!&%!H8&N9:$.%!&)!?$(&':(9!4%$*%-7':.-(9!8(!O9:%&(!&)!=>(!?%'3(!@=HP4;=4KQIKAM

!/////)

J(:):!RM!=.9:)*%!&)!5%3.&%&!4%$*%-"'6:.-%!S)3!=.#3(!TTHM!=M?%'3(U!O&.:($%!Q5PB!VWWXM

H8:)$8%:.(8%3!5(8+)$)8-)!(8!Y%$*(68.9%:.(8!(+!Z)-[8.-%3!Q)0'.$)*)8:9!+($!Q)#.9:$%:.(8!(+!?[%$*%-)':.-%39!+($!Y'*%8! '9)! H5Y!Y%$*(8.9)&!Z$.2%$:.:)!L'.&)3.8)M! H5Y!\X! @QVA! 6!!"#$%#&'()*&#+,-'.'+/0%'1)M! H5YB!=:)2!]!<)$9.(8B!VWW^M!

;M=M! S)2%$:*)8:! (+! Y)%3:[! %8&!Y'*%8! =)$<.-)9! 6! 4((&! %8&!S$'#!K&*.8.9:$%:.(8B!5)8:)$!+($!S$'#!O<%63'%:.(8!%8&!Q)9)%$-[!@5SOQAB!5)8:)$!+($!J.(3(#.-9!O<%3'%:.(8!%8&!Q)9)%$-[!@5JOQAM! ! H5Y!\^!_!L'.&%8-)! +($!H8&'9:$`!6!\'%3.:`!Q.9a!I%8%#)*)8:M!Q(-a<.33)B!ISU!4SKB!R'8)!VWWbM

!"#"$%&'()*+,(-.(/0$1#(')*

H8:)$8%:.(8%3!5(8+)$)8-)!(8!Y%$*(68.9%:.(8!(+!Z)-[8.-%3!Q)0'.$)*)8:9!+($!Q)#.9:$%:.(8!(+!?[%$*%-)':.-%39!+($!Y'*%8!;9)! 6! H5Y!Y%$*(8.9)&!Z$.2%$:.:)!L'.&)3.8)M!H5Y!\cW!6!?[%$6*%-)':.-%3!\'%3.:`!=`9:)*M!H5YM!=:)2!]!<)$9.(8Bd'8)!VWWXM

I($)::(!GSB!5%3.e:(! RM! O9:$':'$%!&(!P(<(!=.9:)*%!&%!\'%3.&%&)!2%$%!%!H8&N9:$.%! 4%$*%-7':.-%M! =>(!?%'3(U!4.8%EE.!?$(2%#%8&%B!<(3'*)!fB!VWW^M

I($)::(! GSB!5%3.e:(! RM!L'.%9! H?O5!Oe-.2.)8:)9!6!J(%9!?$,:.-%9!&)!4%/$.6-%C>(! 6!J(%9!?$,:.-%9!&)!S.9:$./'.6C>(M!=>(!?%'3(U!4.8%EE.!?$(2%#%8&%B!<(3'*)!gB!VWW^M

! K8,3.9)!&)!&.9:$./'.C>(!#$%8'3(*"6:$.-%U!H4K!&)!/%.e%!9(3'/.3.&%&)h!

! 4%.e%! &)! +'9>(U! 2'$)E%! &)! '*!+,$*%-(h!

! S)89.&%&)!-(*2%-:%&%U!&):)$*.68%C>(!)92)-.+.-%Ci)9!2$(-)99(h

! I%99%! )! ,$)%! 9'2)$+.-.%3! )962)-1+.-%9U! +,$*%-(9! &)! /%.e%!9(3'/.3.&%&)h!

! Z)$*(#$%<.*):$.%U!'*.&%&)B!<(3,6:).9B!$)91&'(9B!2'$)E%!9'/9:j8-.%9!-$.9:%3.8%9h!

! 5%3($.*):$.%!Oe23($%:k$.%!S.+)$)86-.%3!@S=5AU!2(3.*($+.9*(h!!

! O92)-:$(+(:(*):$.%!8%!$)#.>(!&(!.8+$%<)$*)3[(!@HDAU!.&)8:.+.-%C>(h

! O92)-:$(+(:(*):$.%!8%!$)#.>(!&(!'3:$%<.(3):%U!.&)8:.+.-%C>(h!

! l$)%! 9'2)$ +.-.%3B! :%*%8[(! )!&.9:$./'.C>(!&(9!2($(9U!<(3'*)B!&)89.&%&)h

! ?($(9.&%&)!&%9!2%$:1-'3%9U!3./)$%6C>(B!*(3[%/.3.&%&)B!)8-[.*)8:(h

! S.+$%C>(!&)! $%.(9!T!m!)9:$':'$%!-$.9:%3.8%B!2(3.*($+.9*(h!

! Z%*%8[(!&)!*.-)3%9!)!-)8:$.+'6#%C>(U!9)2%$%C>(!&)!+%9)9h

! Q)(3(#.%nS)89.&%&)! %2%$)8:)U!)8<%9)!&)!2k9B!-(*2$)99>(h

! I)&.C>(!&)!-($$)8:)U!2(8:(!&)!#$%8'3%C>(!N*.&%M

6*789&:;*5(*!(9!8(<(9!-(8[)-.*)8:(9!)!(!

%<%8C(!&%!:)-8(3(#.%!&.$)-.(8%&%!2%$%!(9!2$(-)99(9!+%$*%-7':.-(9B!(/9)$<%69)!%!8)-)99.&%&)!&)!%0'.9.C>(!&)!)e-.62.)8:)9!/)*!-(8[)-.&(9!)!-(*!9'%9!2$(2$.)&%&)9!&)!0'%3.&%&)!&)+.8.&%9!)! -(8:$(3%&%9!2)3(! +%/$.-%8:)M! ?($!(':$(!%92)-:(B!(! +%/$.-%8:)!&(!*)6&.-%*)8:(!:%*/"*!&)<)!&):)$*.8%$!9'%9!2$k2$.%9!8)-)99.&%&)9!$)3%:.<%9!

%!)92)-.+.-%Ci)9! +19.-%9B!0'1*.-%9!)!*.-$(/.(3k#.-%9!2%$%!(9! +,$*%-(9!)!)e-.2.)8:)9!':.3.E%&(9!)*!9)'9!2$(6&':(9B!&)!*(&(!0')!2(99%!-(8:$(3%$!%!0'%3.&%&)!&(!2$(&':(!+.8%3MK99.*B!(9! )3)*)8:(9! )! -(8-).:(9!

*%.9!$)3)<%8:)9!8(!&)9)8<(3<.*)8:(!&)!2$(&':(9B!8(!j*/.:(!&(9!)e-.2.)8:)9!+%$*%-7':.-(9!9>(U

! \'%3.+.-%C>(!&)!+($8)-)&($)9h

! O9:'&(9!&)!2$"6+($*'3%C>(h

! 5%$%-:)$.E%C>(!&(9! +,$*%-(9! )!)e-.2.)8:)9h

! K5\!)!)92)-.+.-%Ci)9M

O9:)9!)3)*)8:(9B!9)!/)*!#)$)8-.%6&(9! )!*(8.:($%&(9! 2)3%! )*2$)9%B!-(8&'E)*68%! %! (/:)$! 2$(&':(9!+%$*%-7':.-(9! -(*! %3:(! #$%'! &)!0'%3.&%&)!)!-(*! $.9-(9!2(:)8-.%.9!&.*.8'1&(9M

Page 61: Revista Fármacos & Medicamentos (Edição 64)
Page 62: Revista Fármacos & Medicamentos (Edição 64)

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( ! # $ $ $ % & ' & ( ) * + , * - ./ ( ) * + 0 . 1 ./ ( ) * $ " 2 3 2

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

'5)0#(4'&0#!%*(#)!#"'(9%/"#(06'(/57&!8B0# /# !.(!;/5!1/(#)/#9.0)4&0"?#J560%6/,# /# +!)!#6/;#/(#(!'0.# 1.!4#)/# '(90.&A5+'!,#!#1/"&B0#)!"#(4'&!"#'530.(!8C/"#./%/6!5&/"#!0#9.0+/""0#)/#9%!5/K!(/5&0,#/G/+48B0#/#+05&.0%/#)0#

Circular para:

4%5

!"#$%&'()*+,$-#.-#/'012)$,-#$+)3+2$4$,'5623#+-#7(3-#.3#032)8'9#.3:$.'#-#)(-+24'(%-;<32#3,'+=%$,-2#3#)3,+'/>0$,-29#)-$2#,'%'?#0/'@-/$A-;8'9#-/)3(-;<32#3#$+,3()3A-2#+-#3,'+'%$-#%5+.$-/9#&('/$43(-;8'#3#%3+'(32#,$,/'2#.3#:$.-#.3#&('.5)'29#%-$'(32#3B$0C+,$-2#.3#23(:$;'2#3#$+)3+2'#.323+:'/:$%3+)'#)3,+'/>0$,'DE

6789

L e i a n o P o r t a l R a c i n e: : : ; ) < = > ? . ; = * / ; ( )

6@5605

AB4 8CD

%D87@%99E

!"#$%&'$()'*+,-./'(0%(1%&#.%(2%$3%/45-./%6(&%(7$3%8#0%*#3(%'(9$%0,"'$-#(&#(:#&./%3#0-',6&F).G$5<)>.$H>I&.?<I<$H<>'*J$KL(>*$@&>1$D.M>=.)$.$7*N.M>$A<'>N'<$A<)).'*

Page 63: Revista Fármacos & Medicamentos (Edição 64)

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

A Kin Master, há 30 anos, produz insumos farmacêuticos ativos (IFAs) com o objetivo de contribuir na melhoria da qualidade de vida dos indivídu-os, tanto pela efi cácia de seus produtos, como pela metodo-logia de trabalho, atuando com responsabilidade e ética, de maneira social e ecologicamen-te correta. A empresa produz farmoquímicos, destacando-se pela tecnologia avançada e pela seriedade com que atua no mercado. Exportando sua produção para diversos pa-íses, a Kin Master é um ícone em desenvolvimento no setor.

A Kin Master possui experiência no processamento de derivados de origem animal, resultando em uma produção altamente qualifi cada de glicosaminoglicanos, enzimas e extratos. Todos os ingrediente naturais utilizados na produ-ção são previamente aprovados pelas autoridades sanitá-rias do Ministério da Agricultura, Pecuária e Abastecimento (MAPA_. Além disso, os fornecedores das matérias-primas utilizadas pela KM são auditados e controlados.

Para garantir a competitividade da empresa, a Kin Master

investe constantemente em trei-namentos, na busca de inovações, de novos e melhores processos produtivos, na pesquisa e desen-volvimento de novos produtos, com a cooperação de conhecidos centros de pesquisa e universida-des. Apóia, também, a formação universitária de vários colabora-dores, e proporciona cursos de língua estrangeira e treinamentos específi cos quando necessário.

Com uma área de 3.000 m!, a empresa é muito bem estruturada, contando com duas unidades produtivas. Uma responsável pela produção de extratos e a outra pela purificação dos mesmos. A capacidade produtiva operacional da Kin Master é de 18.000 litros, sendo que os equipamentos qualificados atendem plenamente às demandas da produção.

A empresa também possui uma extensão em Buenos Aires, Argentina, que comercializa os produtos Kin Mas-ter e de outras de empresas representadas, e que conta com um departamento responsável pela produção de medicamentos veterinários.

!"#$#%&'()$*+,,-.$%/-012+$3.456578.090$7+$#56809+

Kim.indd 44 dez/07/2010 16:48

0%&.'&7%,1#*%2&7%*&%&%?D'054%&.'&(0',.')&%1&)'>#5150%1&.%&7%,1#*5.%)H9R'10'&(*?5',0'2&<%#4'&#*&-)(,.'&

(#*',0%&.(&7%,7%))G,75(&'&(1&'*/)'1(1&/(11()(*&(&?#17()&,%4(1&!%)*(1&/()(&.'1',4%"4')&#*&.5!')',75("&7%*/'05054%&15-,5!57(054%&'&.#)(.%#)%2&/%51&>#'&(&>#("5.(.'&.%1&/)%.#0%12&>#'&,%&/(11(.%&!%5&#*&5,10)#*',0%&/()(&.5!')',75(6B%2&/(11%#&(&1')&#*&/)'11#/%10%9R%&(1/'70%&!#,75%,("&.(1&'*/)'1(1&

.'&"%-C1057(&8&.510)5?#5.%)(12&()*(+'8,(.%)(1&'&0)(,1/%)0(.%)(1&8&(&7#"0#)(&.(1&?%(1&/)@057(1&,(1&%/')(6E'1&"%-C18057(1&.'&*'.57(*',0%1&3&(5,.(&("-%&,%4%2&/%51&*#50(1&4'+'1&'10(1&(0#(*&'*&%#0)%1&1'-*',0%1&'2&(%&1'&.'/(8)()'*&7%*&%&*')7(.%&!()*(7G#057%&'&.(& 1(S.'2& 1',0'*&.5!57#".(.'1&,(&5*/"(,0(6B%&.(1&*'1*(19&TB%&=%(1&

:)@057(1&3&,(&4').(.'&#*(&!5"%1%!5(&,(&>#("&(1&'*/)'1(1&',4%"45.(1&,'11(1&(0545.(.'1&.'4'*&'10(?'"'7')2&.511'8*5,()&'&*(,0')2&'*&0%.%1&%1&,C4'512&1'0%)'1& '& 0)(?("<(.%)'1& 5,0'),%1& '&'$0'),%1&.(&'*/)'1(9&P1&4(,0(-',1&>#'2&(%& 5*/"(,0()&(1&?%(1&/)@057(12&'11(1&)'-)(1&7%,0)5?#'*&/()(&(&/%"C057(&.'&>#("5.(.'&'&1510'*(&.'&-'10B%&.(&>#("5.(.'&.(1&%)-(,5+(6E'12&,%&("7(,7'&.%1&%?D'054%1&'&*'0(12&'1/'75("*',0'&/()(&*'"<%)&(0',.5*',0%&.%1&7"5',0'19N*&0'*/%1&.'&7%*/'056B%&(75))(.(&

'*&>#'& (1& %)-(,5+(6E'1& %!')'7'*&/)%.#0%1& 15*5"()'1& '*& 0')*%1& .'&/)'6%2& 7()(70')C1057(1& '& >#("5.(.'2&(&.5!')',75(6B%&/%)&*'5%&.%&1')456%&%!')'75.%&(%&7"5',0'&/%.'&-')()&#*(&5*/%)0(,0'& '& 1#10',0@4'"& 4(,0(-'*&7%*/'05054(9& R'10'& 7%,0'$0%2& (1&

Page 64: Revista Fármacos & Medicamentos (Edição 64)

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( ! " # # # $ % & % ' ( ) * + ) , -. ' ( ) * / - 0 -. ' ( ) # 1 2 3 2 ! " # $ % & ' (!) * + , & % $ * - . ' ( ! " # # # $ % & % ' ( ) * + ) , -. ' ( ) * / - 0 -. ' ( ) # 1 2 3 2 # # # 4 5

!"#$!%&%'!"#!()&"*%!'(+',-"#$.*"!(/+'0&%'!1.23(,.&%'%&(./4$.&%5'#&$&'%&/.%6&78+'!'6.0!9.:&78+'0+',9.!(/!;'<&$&'&'9+2=%/.,&5',->+'"&.+$'+?>!/.@+'

A'+6!$!,!$'+%'#$+0-/+%'!'%[email protected]+%'+(0!'%8+'(!,!%%4$.+%'!'(+'"+"!(/+'B-!'%8+'0!%!>&0+%'!'!(/!(0!(0+'B-!'+'(=@!9'0!'%[email protected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email protected]&0!'0+'(!2G,.+;H' /$&(%#+$/!' 0!'"!0.,&"!(/+%'

#&%%&'#+$'-"&' %A$.!'0!'"-0&(7&%',&-%&0&%' #!9&' ,$.&78+' 0!' (+$"&%'0!%0!'B-!'&'.(0I%/$.&'6&$"&,3-/.,&'6+.'/+"&0&'#+$'0!(I(,.&%'0!'6&9%.6.*,&78+'0!'$!"A0.+%5')4'&92-(%'&(+%;'F%'!"#$!%&%'#$!%/&0+$&%'0!'%[email protected]+%'/.@!$&"'B-!'%!'&0!B-&$'&+%'!9!@&0+%'#&0$E!%'0!'B-&9.0&0!'!1.2.0+%'#&$&'+'/$&(%#+$/!'0!'"!0.,&"!(/+%;J!%/!',+(/!1/+5'&'0.%/$.?-.78+'0!'

#$+0-/+%'6&$"&,3-/.,+%5',+(%.0!$&(0+'0!%0!'+%'#$+,!%%+%'0!'&$"&:!(&2!"'&/A'+'/$&(%#+$/!5'$!#$!%!(/&'-"'2$&(0!'0!%&6.+'#&$&'&%'!"#$!%&%'0!'9+2=%/.,&;'H'(=@!9'0!'B-&9.0&0!'0!@!'%!$'"&(/.0+'0-$&(/!' /+0&'&'$!0!'0!'0.%/$.?-.78+5'#&$&'B-!'+%'"!0.,&"!(/+%'(8+'%+6$&"'&9/!$&7E!%'!"'%-&%'#$+#$.!0&0!%'!'!"'%-&'.(/!2$.0&0!;

+6,-7#8-#9-(,:;)<#=()=)9&>#

8-#>,>7:>;?)#8)9#)=-(>8)(-9#

7)@69&:A)9#8-#=()8%&)9#

B>(.>AC%&:A)9

H'+?>!/.@+'0&%'!"#$!%&%'0!' 9+2=%*/.,&',+(%.%/!'!"',+9+,&$'!"'#$4/.,&'-"'#$+>!/+',&#&:'0!'0.6!$!(,.4*9&%5',$.&(0+'@&9+$'#&$&'%!-%',9.!(/!%'#+$'"!.+'0!'-"'%[email protected]+'%-#!$.+$;'H'%!$*@.7+'&+',9.!(/!'A'-"'/!$"+'&"#9+'B-!'.(,9-.'0!%0!'!9!"!(/+%'$!9&,.+(&0+%'C'

0.%#+(.?.9.0&0!'0+'#$+0-/+'&/A'+'&/!(*0."!(/+'#G%*@!(0&;'K+?'&'#!$%#!,/.@&'0&'6-(78+'9+2=%/.,&5'+'%[email protected]+'&+',9.!(/!'A'+' $!%-9/&0+'0!' /+0&%'&%'&/[email protected]&0!%'9+2=%/.,&%;'L!%/&'6+$"&5'+'#$+>!/+'0+'%.%/!"&'9+2=%/.,+'0!/!$".(&'+'(=@!9'0!'%[email protected]+'&'%!$'+6!$!,.0+'&+',9.!(/!;F92-(%'0+%'&/$.?-/+%'"&.%'@&9+$.:&*

0+%'#!9+%',9.!(/!%'!%/8+'.(/."&"!(/!'9.2&0+%' C' +#!$&78+'0!' /$&(%#+$/!5',+"+' !(/$!2&%'"&.%' 6$!BM!(/!%5'0.%#+(.?.9.0&0!' 0!'"!$,&0+$.&%5'&-%3(,.&' 0!' &@&$.&%5' ,-"#$."!(/+'0!' #$&:+%5' .(6+$"&7E!%' %+?$!' +%'#!0.0+%5' !(/$!' @4$.+%' +-/$+%' ./!(%'B-!',$.&"'@&9+$5'&+'$!0-:.$'+%',-%/+%'#&$&' +' ,9.!(/!' !D+-' &-"!(/&$' %-&'@&(/&2!"',+"#!/./.@&;F#G%'&'0!6.(.78+'0+'%!2"!(/+'0!'

"!$,&0+'!"'B-!'&'!"#$!%&'&/-&$45'+'#$G1."+'#&%%+',+(%.%/!'!"' .0!(*/.6.,&$' &%' !1#!,/&/.@&%'0+%' ,9.!(/!%'!'+%' !9!"!(/+%' ,$=/.,+%'0+' %[email protected]+'#&$&'&/!(03*9&%;'N"'%!2-.0&5'0!@!*%!'.0!(/.6.,&$',+"+'+'0!%!"#!()+'0!%*/!%'!9!"!(/+%'!%/4'%!(0+',+(/$+9&0+'!5'#+$'6."5'@!$.6.,&$'&'B-&9.0&0!'!'&',&#&,./&78+'0+%'%.%/!"&%'.(/!$(+%'0&'!"#$!%&;'F'&(49.%!'0!%%!%'#$+,!%%+%'

.(/!$(+%'#!$"./!'&@&9.&$' %!'&'!%#!*,.6.,&78+'0+' %[email protected]+'!%/4' $!69!/.(0+'&%' !1#!,/&/.@&%' 0+%' ,9.!(/!%;' <&$&'/&(/+5'-/.9.:&"*%!'0!'.(0.,&0+$!%'0!'0!%!"#!()+5'&,+"#&()&0+%'(+'2!*$!(,.&"!(/+'0!'$+/.(&'!'!"'&-0./+$.&%'.(/!$(&%5'&(/!,.#&(0+'#$+?9!"&%'B-!'#+0!$8+'%!$'0!%,+?!$/+%'!"'&-0./+$.&%'!1/!$(&%;O9.!(/!%' 0!' %!2"!(/+%' 0.%/.(/+%'

0!@!"'%!$'/$&/&0+%'0!'6+$"&'0.6!$!(*/!5'&6.(&95',9.!(/!%'0.6!$!(/!%'#+0!"'0!%!>&$'0.6!$!(/!%'(=@!.%' !' /.#+%'0!'%[email protected]+;'L!%/&'6+$"&5'&(/!%'0!'/$&7&$'B-&9B-!$'!%/$&/A2.&5'&'!"#$!%&'0!@!'0!6.(.$'+'%!2"!(/+'0!'"!$,&0+'B-!'%!$4' &/!(0.0+' !' +%' !9!"!(/+%' B-!',+"#+$8+'+'%[email protected]+'&'%!$'#$!%/&0+;'F%%."5'#&$&'&/!(0!$'#9!(&"!(/!'&'-"'0!/!$".(&0+'%!2"!(/+5'!"'#$."!.$+'9-2&$'A'(!,!%%4$.+'.0!(/.6.,&$'B-&.%'%8+'!%/!%'&%#!,/+%'0!'0!%!"#!()+'(+%'B-&.%'%-&%'!1#!,/&/.@&%'&#&$!,!"P'0!%/&'6+$"&5'&'!"#$!%&'#+0!$4'6+,&9.:&$'%!-%'!%6+$7+%'#&$&'B-!'%-&'+#!$&78+'&/.(>&'!9!@&0+'0!%!"#!()+'(+%'&%#!,/+%'B-!' %!-%' ,9.!(/!%' &9@+' ,+(%.0!$&"'."#+$/&(/!%'&"#9.&(0+'%-&%',)&(,!%'0!'(+@+%'(!2G,.+%;

D-:>#>#,-(9?)#:E&-@(>7#8-9&-#>(&:@)#E)#4)(&>7#F>A:E-<#GGGH(>A:E-HA).H'(

!/////)

!"#$%&'()$*%'+*,"%-),)'+)*./'A'2$&0-&0&'!"'6&$"4,.&'#!9&'Q(.@!$%.*0&0!'O&".9+'O&%/!9+'R$&(,+'SQJTOFKUNVHW5'!%#!,.&9.%/&'!"'%&I0!'#I?9.,&'#!9&'Q(.@!$%.0&0!'0!'X.?!.$8+'<$!/+' SQJFNX<W'!'!%#!,.&9.%/&'!"'F-0./+$.&'Y&$"&,3-/.,&'*'Y+$"&78+'0!'F-0./+$!%'#&$&'&'O&0!.&'T(0-%/$.&9'Y&$"&,3-/.,&'#!9+' T(%/./-/+'X&,.(!;'F/-&9"!(/!'A'F%%.%/!(/!'UA,(.,&'0!'<9&(!>&"!(/+'0!'F7E!%'0&'K&I0!'TT'SFU<FK'TTW'(&'L.@.%8+'UA,(.,&'0!'Z!0.,&"!(/+%'0+'O!(/$+'0!'[.2.9\(,.&'K&(./4$.&'0+'N%/&0+'0!'K8+'<&-9+'SO[KDK<W;'

012*/'3"*4'5%6*7%$' A' 2$&0-&0+' !"' 6&$"4,.&' !' !%#!,.&9.%/&' !"'&(49.%!%',9=(.,&%'#!9&'Q(.@!$%.0&0!'<&-9.%/&' SQJT<W' !' !%#!,.&9.%/&' !"'F-0./+$.&' Y&$*"&,3-/.,&' *' Y+$"&78+'0!'F-0./+$!%'#&$&' &'O&0!.&' T(0-%/$.&9' Y&$"&,3-/.,&'#!9+' T(%/./-/+'X&,.(!;'F/-&9"!(/!' A' ,++$0!(&0+$' 6&$"&,3-/.,+'0+' %!/+$'0!'B-.".+/!$&#.&'0+']+%#./&9'R&(0!.$&(/!%;

8/9%6*':).*9.)':)$$%./' A' 2$&0-&0&' !"' 6&$"4,.&'#!9&'Q(.@!$%.0&0!' Y!*0!$&9'0&'R&).&' SQYRFW5'!%#!,.&9.%/&'!"'F-0./+$.&'Y&$"&,3-/.,&' *' Y+$"&78+'0!'F-0./+$!%' #&$&' &'O&0!.&' T(0-%/$.&9' Y&$"&,3-/.,&'#!9+' T(%/./-/+'X&,.(!;'F/-&9"!(/!'A',++$0!(&0+$&'0!'6&$"4,.&')+%#./&9&$'S4$!&'0!'%-#$."!(/+%W'0+']+%#./&9'F(&'J!$.;

L e i a n o P o r t a l R a c i n eG G G H ( > A : E - H A ) . H ' (

Page 65: Revista Fármacos & Medicamentos (Edição 64)

! " ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % 3 4 5 4 ! " # $ % & ' (!) * + , & % $ * - . ' ( # $ % % % & ' ( ' ) * + , - + . /0 ) * + , 1 / 2 /0 ) * + % 3 4 5 4 % % % # 6

N a v e g u e! / 7 8 ' 9 7 :%; < = > 9 ? :

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

]]]VE*+(/?V+*LV)*G%!"#$%/)%`-60$/)/$%J.)"0+$0.)%S.IA=1-2)45-%a$61-+I306)%US.-#$6V%/02'+3)%)""'1#-"%/$%01#$.$""$%_"%B.$)"%/$%*$"R'0")%$%/$"$12-+20($1#-%/$%01-2)4<$"%#$61-+I306)"%1-%J.)"0+@%20")1/-%)%).#06'+)45-%$1#.$%-%"$#-.%*.-/'#02-@%)"%01"#0#'04<$"%#$61-+I30A6)"%$%-"%I.35-"%/$%3-2$.1-:%;-(%,-.#$%01#$3.)45-%6-(%-%=1"#0#'#-%/$%S$"R'0")%$%?$"$12-+20($1#-%/$%bB.()6-"%$%S.-/'#-"%b).()6E'#06-"%U=S?Ab).()V@%)*.$"$1#)%01,-.()4<$"% $(%/02$.")"% B.$)"@% $1#.$% $+)"@% 01/8"#.0)% ,).()6E'#06)@%K'()1)%$%2$#$.01B.0)@%/$%R'7(06)%,01)%$%90-#$61-+-30):%P%'(%!"#$%6-(%)#')+0])4<$"@%1-#760)"@%*'9+06)4<$"@%+$30"+)45-@%$/0#)0"%$%/02'+3)45-%/$%$2$1#-"%/-%"$#-.:

]]]V?<9>9?:V?+V'^Y%*B301)%/)%c-.+/%H$/06)+%a$6K1-+-3d%W$e"%&%2-+#)/)%*).)%)%B.$)%/$%90-#$6A1-+-30)@%6-(%,-6-%1-%"$#-.%/$%/$206$"%$%/0)31I"#06-":%a.)]%01,-.()4<$"%"-9.$%S>?@%+$30"+)45-@%2030+X160)@%)1B+0"$"%/$%($.6)/-@%1$3I60-"@%$1#.$20"#)"@%).#03-"%$%27/$-":%S-""'0%'()%"$45-%*-.%.$305-%$(%R'$%)"%1-#760)"%$%)"%)#')+0])4<$"%*-A/$(%"$.%)3.'*)/)"%$%+-6)+0])/)"%*-.%9+-6-"%$6-1f(06-"T%g`Y@%!'.-*)@%Y(&.06)%h)#01)@%i"0)%$%S)67,06-%$%H'1/-:%!Q0"#$(%01,-.()4<$"%01#$.$"")1#$"%"-9.$%=>?%$%$(*.$")"%!#%&#'()!%$(%90-#$61-+-30)%$%1)1-#$61-+-30):

!

!

Page 66: Revista Fármacos & Medicamentos (Edição 64)
Page 67: Revista Fármacos & Medicamentos (Edição 64)
Page 68: Revista Fármacos & Medicamentos (Edição 64)

Recommended