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1.Agrawal, PB., Pandi, AB. (2003). Isolation of alphaglucosidase from Saccharomyces cerevisiae, Cell disruption and adsorption. Biochem Ene J, 15; 37-45.2.Aguilar- Uscanga, B., Francois, JM. (2003). A study of the yeast cell wall composition and structure in response to growth conditions and mode of cultivation. Appl Microbiol, 37; 268-274.3.Bonyadi, F., Tukmechi, A., Nejati, V. (2012). Comparative study on the effect of obtained cell
wall and cytoplasmic fraction from Saccharomyces cerevisiae and Saccharomyces boulardii on K562 cell line. Pharm Sci, 18; 69-78. 4.Ferringer, T., Miller, OF. (2002). Cutaneus manifestations of diabetes mellitus. Dermatol Clin, 20; 483-92. 5. Gomes, AC., Bueno, AA., Machado Souza, RG., Mota, JF. (2014). Gut microbiota,
Probiotics and diabetes. Nutrition Journal, 13; 60. 6.Gontcharova, V., Youn, E., Sun, Y., Wolcottr, D., Dowd, SE. (2010). A comparison of bacterial composition in diabetic ulcers and contralateral intact skin. The Open Microbiology Journal, 4; 8-19. 7.Gupta, AK., Koonikov, N., Macdonald, P. (1998). Prevalence and epidemiology of toenail onychomycosis in diabetics: a multicenter survey. Br J Dermatol, 139; 665-71.
8.Hoseinifar, SH., Mirvaghefi, A., Mojazi Amiri, B., Khoshbavar Rostami, H., Merrifield, DL. (2011). Effects of oligofructose on growth performance, survival and autochthonous intestinal microbiota of beluga (Huso huso). Juvenile Aquaculture Nutrition, 17; 498-504.9.Jobbour, SA., Miller, JL. (2000). Endocrinopathies and the skin. Int J Dermatol, 39; 88-99. 10.Kim, J., Woo, HJ., Kim, YS., Kim, KH., Lee, HJ. (2003). Cell cycle deregulation induced by cytoplasmic of Lactobacillus lactis spp. in
Capparis spinosa
62
SNUC2A, a colon cancer cell line. Nutr Cancer, 46; 197-201. 11.Klis, FM., Mol, P., Helingwerf, K. (2002). Dynamics of cell wall structure in Saccharomyces cerevisiae. FEMS Microbiol, 26; 239-256. 12.Kurtmann, J. (2009). Pre- and Probiotics for human skin. J Dermatol Sci, 54;1-5. 13.Ring, E., Olsen Regifstad, TO., Dalmo, RA., Amlund, H., Hemre, GI. Bake, AM. (2010). Prebiotics in aquaculture: a review. Aquaculture Nutrition, 16;117-136. 14.Sener, G., Ecsioglu-Demiraop, E., Cetiner, M., Ercan Yegen, BC. (2006). Beta glucan ameliorates methotrexate induced oxidative organinjury via its antioxidant and immunomo dulatory effects. Europ J Pharmacol, 542;170-178.
15.Smith, K. (1997). Ulcerating necrobiosis lipoidica resolving in response to cyclos Porin-A. Dermatol Online J, 3;2. 16.Tatti, R., Abolghasemi, SJ., Tatina, M., Nasre Tajan, M. (2012). Influence of prebiotic immune wall on growth performance, body composition and immune physiological variables in juvenile great sturgeon, Huso huso. Annals of Biological Research, 3(9); 4435-4441. 17.Tuchmechi, A., Rahmati Andani, HR., Sheikhzadeh, N. (2011). Dietary administration of beta-mercapto-ethanol treated Saccharomyces cerevisiae enhanced the growth, innate immune response and disease resistance of the rainbow trout, Onco rhynchus mykiss. Fish shellfish Immune, 30: 923-8. 18.Westran, RP., Struthers, JK. (2003). Clinical bacteriology. Manson Publishing, 45-54.