UFRGSUNIVERSIDADE RIO GRANDE DO SULFEDERAL DO
Farmacologia e neurobiologia da dor, estresse, cronobiologia e cronofarmacologiaexperimental.
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INSTITUTO DE CIÊNCIAS BÁSICAS DA SAÚDECONTATOS: Profa. Dra. Iraci Lucena da Silva Torres 55 51 3308 [email protected]
PESQUISACiência, Tecnologia e Inovação
UNIVERSIDADE RIO GRANDE DO SULFEDERAL DO
FARMACOLOGIA
24-Hour Temporal Pattern of NTPDase and 5’-Nucleotidase Enzymes in Rat Blood Serum. Chronobiology International, in press.
Fig. 1 the hydrolysisof ATP, ADP, and AMPwere evaluated in bloodserum during one 24 -h span at ZT 0, 6, 12,and 18.
Fig 2. physiological levelsof corticosterone and melatonin during 24 hin blood serum.
Morphine exposure in early life increases nociceptive behaviour in a rat formalin tonic pain model in adult life. Develop Brain Res, in press.
Fig 1. Effects of indomethacin administration 30 min before the formalin test at P30 (A) and P60 (B) after repeated morphine administration in early life.
Fig 2. Effects of ketamine administration 30 min before the formalin test at P30 and P60 after repeated morphine administration in early life
Principais resultados publicados pelogrupo:
Long-term effect of morphine administrationin young rats on the analgesic opioid responsein adult life . Int J Dev Neurosci, 26:561-5,2008.
Fig 1. after 7 days of dailymorphine administrationthe animals did notdemonstrate developmentof tolerance . The analgesiceffect was observed until90 min after morphineadministration.Fig 2. effect of a secondrepeated morphine administration between P80 and P86 on nociceptiveresponse. The analgesic effect was observed until 30 min after administrationof morphine, but only the morphine/morphine group remained analgesic until 60 min .
Neonatal morphine exposure alters E-NTPDase activity and gene expression patternin spinal cord and cerebral cortex of rats. Eur JPharmacol., 642:72-6, 2010 .
Fig 1. ATP, ADP, and AMP hydrolysis in synaptosomesfrom spinal cord and cerebral cortex at 16 days of age .Fig 2. E-NTPDase1, 2, 3, and 5 -nucleotidase mRNA transcript levels from spinal cord of male rats at 16 days of age.
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