UFRGS UNIVERSIDADE RIO GRANDE DO SUL FEDERAL DO Farmacologia e neurobiologia da dor, estresse, cronobiologia e cronofarmacologia experimental. CIÊNCIAS BIOLÓGICAS FARMACOLOGIA NEUROPSICO- FARMACOLOGIA DOR E NEUROMODULAÇÃO INSTITUTO DE CIÊNCIAS BÁSICAS DA SAÚDE CONTATOS: Profa. Dra. Iraci Lucena da Silva Torres 55 51 3308 3894 [email protected] PESQUISA Ciência, Tecnologia e Inovação UNIVERSIDADE RIO GRANDE DO SUL FEDERAL DO FARMACOLOGIA 24-Hour Temporal Pattern of NTPDase and 5’-Nucleotidase Enzymes in Rat Blood Serum. Chronobiology International, in press. Fig. 1 the hydrolysis of ATP, ADP, and AMP were evaluated in blood serum during one 24 -h span at ZT 0, 6, 12, and 18. Fig 2. physiological levels of corticosterone and melatonin during 24 h in blood serum. Morphine exposure in early life increases nociceptive behaviour in a rat formalin tonic pain model in adult life. Develop Brain Res, in press. Fig 1. Effects of indomethacin administration 30 min before the formalin test at P30 (A) and P60 (B) after repeated morphine administration in early life. Fig 2. Effects of ketamine administration 30 min before the formalin test at P30 and P60 after repeated morphine administration in early life Principais resultados publicados pelo grupo: Long-term effect of morphine administration in young rats on the analgesic opioid response in adult life. Int J Dev Neurosci, 26:561-5,2008. Fig 1. after 7 days of daily morphine administration the animals did not demonstrate development of tolerance . The analgesic effect was observed until 90 min after morphine administration. Fig 2. effect of a second repeated morphine administration between P80 and P86 on nociceptive response. The analgesic effect was observed until 30 min after administration of morphine, but only the morphine/morphine group remained analgesic until 60 min . Neonatal morphine exposure alters E- NTPDase activity and gene expression pattern in spinal cord and cerebral cortex of rats. Eur J Pharmacol., 642:72-6, 2010 . Fig 1. ATP, ADP, and AMP hydrolysis in synaptosomes from spinal cord and cerebral cortex at 16 days of age . Fig 2. E-NTPDase 1, 2, 3, and 5 -nucleotidase mRNA transcript levels from spinal cord of male rats at 16 days of age.

PESQUISA UFRGS Ciência, Tecnologia e Inovação · CONTATOS: Profa. Dra. Iraci Lucena da Silva Torres 55 51 3308 3894 [email protected] PESQUISA Ciência, Tecnologia e Inovação

Download PDF Report

Upload
hoangxuyen
View
214
Download
0

Embed Size (px)

Citation preview

Page 1: PESQUISA UFRGS Ciência, Tecnologia e Inovação · CONTATOS: Profa. Dra. Iraci Lucena da Silva Torres 55 51 3308 3894 iracitorres@gmail.com PESQUISA Ciência, Tecnologia e Inovação

UFRGSUNIVERSIDADE RIO GRANDE DO SULFEDERAL DO

Farmacologia e neurobiologia da dor, estresse, cronobiologia e cronofarmacologiaexperimental.

CIÊ

IAS

BIO

LÓG

ICA

SFA

OLO

GIA

NEU

PSI

-FA

OLO

GIA

R E

EUR

ULA

ÇÃ

INSTITUTO DE CIÊNCIAS BÁSICAS DA SAÚDECONTATOS: Profa. Dra. Iraci Lucena da Silva Torres 55 51 3308 [email protected]

PESQUISACiência, Tecnologia e Inovação

UNIVERSIDADE RIO GRANDE DO SULFEDERAL DO

FARMACOLOGIA

24-Hour Temporal Pattern of NTPDase and 5’-Nucleotidase Enzymes in Rat Blood Serum. Chronobiology International, in press.

Fig. 1 the hydrolysisof ATP, ADP, and AMPwere evaluated in bloodserum during one 24 -h span at ZT 0, 6, 12,and 18.

Fig 2. physiological levelsof corticosterone and melatonin during 24 hin blood serum.

Morphine exposure in early life increases nociceptive behaviour in a rat formalin tonic pain model in adult life. Develop Brain Res, in press.

Fig 1. Effects of indomethacin administration 30 min before the formalin test at P30 (A) and P60 (B) after repeated morphine administration in early life.

Fig 2. Effects of ketamine administration 30 min before the formalin test at P30 and P60 after repeated morphine administration in early life

Principais resultados publicados pelogrupo:

Long-term effect of morphine administrationin young rats on the analgesic opioid responsein adult life . Int J Dev Neurosci, 26:561-5,2008.

Fig 1. after 7 days of dailymorphine administrationthe animals did notdemonstrate developmentof tolerance . The analgesiceffect was observed until90 min after morphineadministration.Fig 2. effect of a secondrepeated morphine administration between P80 and P86 on nociceptiveresponse. The analgesic effect was observed until 30 min after administrationof morphine, but only the morphine/morphine group remained analgesic until 60 min .

Neonatal morphine exposure alters E-NTPDase activity and gene expression patternin spinal cord and cerebral cortex of rats. Eur JPharmacol., 642:72-6, 2010 .

Fig 1. ATP, ADP, and AMP hydrolysis in synaptosomesfrom spinal cord and cerebral cortex at 16 days of age .Fig 2. E-NTPDase1, 2, 3, and 5 -nucleotidase mRNA transcript levels from spinal cord of male rats at 16 days of age.