Vrus: De criadores a destruidores da vida

Atila IamarinoVrus e a rvore da Vidahttp://scienceblogs.com.br/rainha/@oatila

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1Questo de perspectivaO que so os vrus

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30 nm30x10-9m35 m35x10-6m

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30 nm30x10-9m35 m35x10-6m

300 nm3x10-7m

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280 m100 000 partculas produzidas aps 4 a 6 horas22,3 cm2,2x10-1m

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2Estratgias de replicaoDiversidade

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RNAmRNA+DNAfs+RNA+ RTDNAfs-RNA-DNAdfRNAdfDNAds

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ArqueasBactriasEucariotosProtistasIPFungosPlantasMetazoriosDNAfdDNAfsRNAfdRNA+RNA-RetroAdaptado de - 1. Nasir A, Forterre P, Kim KM, Caetano-Anolls G. The distribution and impact of viral lineages in domains of life. Front Microbiol. 2014;5: 15. doi:10.3389/fmicb.2014.00194

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Hipteses sobre sua origem:

Estavam sempre aqui

Parasita que regrediuElemento gentico desgovernado

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3Redescoberta tardia O que so os vrus?

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109 partculas por ml1030 a 1031 partculas270 Mt de Carbono20 a 40% das bactrias

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Mimivrus, Megavrus e Pandoravrus

600 nm

Legendre, M., Bartoli, J., Shmakova, L., Jeudy, S., Labadie, K., Adrait, A., et al. (2014). Thirty-thousand-year-old distant relative of giant icosahedral DNA viruses with a pandoravirus morphology. AS, 111(11), 42744279. doi:10.1073/pnas.13206701111m

1,5 m

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Virofgos Lavidaviridae

50 nmLa Scola, B., Desnues, C., Pagnier, I., Robert, C., Barrassi, L., Fournous, G., et al. (2008). The virophage as a unique parasite of the giant mimivirus. Nature, 455(7209), 100104. doi:10.1038/nature07218Krupovic M, Kuhn JH, Fischer MG (2016), "A classification system for virophages and satellite viruses, Archives of Virology 161: 23347, doi:10.1007/s00705-015-2622-9

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Adaptado de - Pennisi, E. (2013, July 19). Ever-bigger viruses shake tree of life. Science, pp. 226227. doi:10.1126/science.341.6143.226

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4A rvore da vidaVivos ou Mortos?

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Belyi, V., Arnold J Levine, and Anna Marie Skalka. 2010. Unexpected Inheritance: Multiple Integrations of Ancient Bornavirus and Ebolavirus/Marburgvirus Sequences in Vertebrate Genomes.. PLoS Pathogens 6 (7): e1001030. doi:10.1371/journal.ppat.1001030.Vrus de RNA, novos ou antigos?

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Adaptado de - Nasir A, Sun F-J, Kim KM, Caetano-Anolls G. Untangling the origin of viruses and their impact on cellular evolution. Ann N Y Acad Sci. 2015; n/an/a. doi:10.1111/nyas.12735

Parasita regredido: Quarto domnio da vida?

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Quarto domnio da vida?Adaptado de Yutin, Natalya, Yuri I Wolf, and Eugene V Koonin. Origin of Giant Viruses From Smaller DNA Viruses Not From a Fourth Domain of Cellular Life. Virology 2014; 466-467: 3852. doi:10.1016/j.virol.2014.06.032.

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Krupovic, Mart, and Eugene V Koonin. 2015. Polintons: a Hotbed of Eukaryotic Virus, Transposon and Plasmid Evolution. Nature Reviews Microbiology 13 (2). Nature Publishing Group: 10515. doi:10.1038/nrmicro3389.Eles estavam aqui desde o comeo

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Elemento genticoKrupovic, Mart, and Eugene V Koonin. 2015. Polintons: a Hotbed of Eukaryotic Virus, Transposon and Plasmid Evolution. Nature Reviews Microbiology 13 (2). 10515. doi:10.1038/nrmicro3389.DNApol - POLIntegrase INTATPaseprotease

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AutonomiaKoonin, E. V., & Starokadomskyy, P. (2016). Are viruses alive? The replicator paradigm sheds decisive light on an old but misguided question. Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences. http://doi.org/10.1016/j.shpsc.2016.02.016

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Hipteses sobre sua origem:

Estavam sempre aqui

Parasita que regrediuElemento gentico desgovernado

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