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Necrose e

apoptose

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Depleção de ATP

ATP-ase de

 sódio e potássio

Síntese

de proteínas

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Depleção de ATP

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Necrose

Necrose é umconceito morfológico

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Necrose

Necrose consiste nas

alterações morfológicas

ue seguem a morte

celular num tecido !i!o

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"orte celular 

#Suicídio$Acidental

so% controle celular 

disfunção celular irre!ersí!el "orte celular programada

&stímulos de morte (ex: Fas-L)

Aus'ncia de estímulos de

so%re!ida (ex: fibroblasto - matriz)

Agentes agressores (ex: lesão

mitocondrial)

Dano do material genético

Tumefação celular 

NecroseApoptose

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Depleção de ATP

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"orfologia da necrose

Processos(

- digestão en)imática

- denaturação protéica

Apar'ncia *istológica(

- alterações nucleares gra!es- *ipereosinofilia citoplasmática

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"orfologia da necrose

 A) Tumefação celular B) Célula normal C) ecrose

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"orfologia da necrose

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! "ue não é necrose

#re$araç%es &istol'icas

orte $or fixação *! crime $erfeito+

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! "ue não é necrose

orte s,bita sem

tradução morfol'ica

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! "ue não é necrose

Autólise

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orfoloia da necrose

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Picnose

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+ariorré,is

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+ariólise

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Necrose

Necrose consiste nas

alterações morfológicas

ue seguem a morte

celular num tecido !i!o

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orfoloia da a$o$tose

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orfoloia da a$o$tose

em células tumorais em e$itélio escamoso

as &e$atites irais a$o$tose necrose

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normal

a$o$tose

(inicial)

a$o$tose(tradia) necrose

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Tipos de necrose

Necrose de coagulação isu'mica.

Necrose liuefati!a

Necrose caseosa

/ f t l d l ã .

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/nfarto renal necrose de coagulação.

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/nfarto renal modelo e,perimental.

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/nfarto renal modelo e,perimental.

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/nfarto renal modelo e,perimental.

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Necrose de coagulação isu'mica.

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Tecido renal normal

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/nfarto renal

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/nfarto renal"edula renal normal

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+ariólise

Picnose

+ariorré,is

/nfarto agudo do miocárdio necrose de coagulação.

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/nfarto agudo do miocárdio necrose de coagulação.

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ecrose li"uefatia

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#us

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#us

#,stula Abscesso

eninite $urulenta

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Apendicite aguda

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Apendicite aguda

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Apendicite aguda

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Apendicite aguda

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Pneumonia %acteriana

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"eningite %acteriana aguda

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"eningite %acteriana aguda

/nfarto isu'mico cere%ral

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/nfarto isu'mico cere%ral

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Neur0nio !ermel*o

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Infarto cerebral antigo

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Infarto cerebral antigo

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Necrose caseosa

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Necrose caseosa

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Necrose do tecido adiposo

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Necrose do tecido adiposo

Necrose do tecido adiposo

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Necrose do tecido adiposo

Necrose do tecido adiposo

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Necrose do tecido adiposo

Necrose do tecido adiposo

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Necrose do tecido adiposo

Necrose do tecido adiposo

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Necrose do tecido adiposo