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UNIVERSIDADE FEDERAL DE UBERLNDIA
INSTITUTO DE CINCIAS BIOMDICAS
REA DE CINCIAS FISIOLGICASCURSO DE BIOMEDICINA
ESTUDO DIRIGIDO DE FARMACOLOGIA Distribuio, Metabolismo e Eliminao de Frmacos
Prof. Dr. Hudson Armando Nunes Canabrava
NOME:_______________________________________________________TURMA:___ No DE MAT.:___________
Nome por Extenso bem Legvel
Uberlndia, ______ de _______________ de 20____ _______________________________________________
Assinatura do(a) Aluno(a)
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Visto do(a) Professor(a)
Vista dada em: _____/_____/20______
Pedido de Reviso em: _____/_____/20______
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______________________________________________ Assinatura do(a) Aluno(a) na vista da Prova
Observaes do(a) Professor(a):
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Visto do(a) Professor(a)
1 - Defina o Metabolismo de Primeira Passagem e explique como esse fenmeno pode interfere na farmacocintica das drogas administradas pela via oral (citando exemplos). __________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________2- Um acadmico do curso de Biomedicina iniciou estgio de iniciao cientfica no laboratrio de Farmacologia e foi incumbido de calcular o volume de distribuio aparente de um princpio ativo, extrado de uma planta do Cerrado, o qual apresenta potencial teraputico. O volume de distribuio calculado para o princpio foi de 68 L /Kg. O aluno, apesar de bem orientado com relao os procedimentos experimentais a serem seguidos e com relao aos clculo a serem realizados, espantou-se com o valor, j que ouvira em suas aulas de Fisiologia que o volume de gua em um homem de 70 kg de aproximadamente 40 L. Assim, intrigado, pensou inclusive em repetir os experimentos, j que julgou ter cometido algum erro gritante. Seu orientador estava participando de um congresso, de forma que ele no tinha com quem dividir sua aflio. Contudo, na hora do almoo ele lhe encontra e comenta o ocorrido. Voc diria a ele que de fato um grande erro foi cometido? Por qu?
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3- Embora o paracetamol seja um analgsico-antipirtico muito seguro em doses teraputicas, na dosagem excessiva pode ocorrer hepatotoxicidade aguda grave. Descreva o mecanismo desse fenmeno, incluindo uma possvel interao com etanol. ______________________________________________________________________________________________
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_________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________________4- SC e AP, de 19 e 20 anos, respectivamente, engravidaram mesmo utilizando contraceptivos orais que contem etinilestradiol, um estrognio sinttico que metabolizado pela CYP3A4. Poucas semanas antes de descobrirem a gravidez, SC estava utilizando rifampicina para o tratamento da tuberculose e AP um antibitico de amplo espectro, ampicilina, para o tratamento de uma infeco das vias areas superiores. Estudos realizados em animais de laboratrio indicam que a ampicilina diminuiu a populao de bactrias da flora intestinal durante o perodo de tratamento, mas a rifampicina o faz apenas inicialmente, de forma que nesse caso a ao sobre a flora pode ser desconsiderada. Baseado nos dados acima e em conhecimentos de farmacocintica, avente explicaes para a gravidez no planejada de SC e de AP.
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5- A figura abaixo mostra a excreo urinria do fenobarbital (pka 7,3), um cido fraco, em diferentes condies de pH urinrio.
Explique as diferenas observadas utilizando o pH 7,0 como referncia. ______________________________________________________________________________________________
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