UNIVERSIDADE FEDERAL DE UBERLNDIA
INSTITUTO DE CINCIAS BIOMDICAS
REA DE CINCIAS FISIOLGICASCURSO DE BIOMEDICINA
ESTUDO DIRIGIDO DE FARMACOLOGIA Distribuio, Metabolismo e
Eliminao de Frmacos
Prof. Dr. Hudson Armando Nunes Canabrava
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Nome por Extenso bem Legvel
Uberlndia, ______ de _______________ de 20____
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Assinatura do(a) Aluno(a)
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Visto do(a) Professor(a)
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Aluno(a) na vista da Prova
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Visto do(a) Professor(a)
1 - Defina o Metabolismo de Primeira Passagem e explique como
esse fenmeno pode interfere na farmacocintica das drogas
administradas pela via oral (citando exemplos).
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Um acadmico do curso de Biomedicina iniciou estgio de iniciao
cientfica no laboratrio de Farmacologia e foi incumbido de calcular
o volume de distribuio aparente de um princpio ativo, extrado de
uma planta do Cerrado, o qual apresenta potencial teraputico. O
volume de distribuio calculado para o princpio foi de 68 L /Kg. O
aluno, apesar de bem orientado com relao os procedimentos
experimentais a serem seguidos e com relao aos clculo a serem
realizados, espantou-se com o valor, j que ouvira em suas aulas de
Fisiologia que o volume de gua em um homem de 70 kg de
aproximadamente 40 L. Assim, intrigado, pensou inclusive em repetir
os experimentos, j que julgou ter cometido algum erro gritante. Seu
orientador estava participando de um congresso, de forma que ele no
tinha com quem dividir sua aflio. Contudo, na hora do almoo ele lhe
encontra e comenta o ocorrido. Voc diria a ele que de fato um
grande erro foi cometido? Por qu?
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3- Embora o paracetamol seja um analgsico-antipirtico muito
seguro em doses teraputicas, na dosagem excessiva pode ocorrer
hepatotoxicidade aguda grave. Descreva o mecanismo desse fenmeno,
incluindo uma possvel interao com etanol.
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SC e AP, de 19 e 20 anos, respectivamente, engravidaram mesmo
utilizando contraceptivos orais que contem etinilestradiol, um
estrognio sinttico que metabolizado pela CYP3A4. Poucas semanas
antes de descobrirem a gravidez, SC estava utilizando rifampicina
para o tratamento da tuberculose e AP um antibitico de amplo
espectro, ampicilina, para o tratamento de uma infeco das vias
areas superiores. Estudos realizados em animais de laboratrio
indicam que a ampicilina diminuiu a populao de bactrias da flora
intestinal durante o perodo de tratamento, mas a rifampicina o faz
apenas inicialmente, de forma que nesse caso a ao sobre a flora
pode ser desconsiderada. Baseado nos dados acima e em conhecimentos
de farmacocintica, avente explicaes para a gravidez no planejada de
SC e de AP.
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5- A figura abaixo mostra a excreo urinria do fenobarbital (pka
7,3), um cido fraco, em diferentes condies de pH urinrio.
Explique as diferenas observadas utilizando o pH 7,0 como
referncia.
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