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Problem/background : fl ryur/ rmnfl aro{Rr:ririi'uResearch question/objective r rflrmruru/rirorrL
: :l:vrnul:ruurura/n6frn: Case report, retrospective, prospective, randomized trial
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Objective
Setting
Design
Subjects
Method
Results
Limpaphayom K, Taechakraichana N. Poshyachinda M, Jaisamran U. Effect of hormonal
replacement therapy on bone changes in Thai menopausal women : a preliminary reports.
Chula Med J ree4 Nov ; 88 (11) : 6?e-8?.
Setting
Research design
Patients/material
Methods (intervention/
measurement/ statistics)
Results
Conclusion
Key words
To study the effect of hormonal replacement therapy on bone changes.
Menopause Clinic Departrnent of Obsterics and Gynecology, Faculry of Medicine,
Chulalongkorn University.
Prospective, randomized study
One hundred and thirty seven premenopausal and postmenopausal women with
age range of ao-oz (mean + SD = 48.62 t z.ob) years were recruited into the
study. Women in the study group (zz/tlz) used esfrogen replacement therapy
either with or without progestogen. The control group (oo/rsz) did not use
hormonal regimens.
Bone mass density was measured at both lumbar spines and hips in each clients
with Dual Energy X-ray Absorptiometry (DEXA) at o and o months.
There were no significant difference in bone changes between the study group
(Lumbar spines : 0.48 ! o.7oo/o ; Hips : 0.b6 L t.76/o) and the control group
(Lumbar spines i 2.s7 + L.zs/o; Hips : 1.Bz t Laso/o) in the first six-month ofbone monitoring. Nevertheless, when considered into the surgical menopausal
women, it showed that there was tendency of greater bone loss in the non-hormonal
group (Lumbar spines : 0.48 + s.lso/o; Hips : 0.b6 + vTao/o) than in the hormonal
teated goup (Lumbar : -1.70 ! o.78o/o; Hips i -2.8 X o.56o/o)t though there was
no statistically signifrcant difference.
Conclusion : The preliminary results showed some beneficial effects of hormonal replacement
therapy (fRT) in slowing bone loss especially in the group of surgical menopausal,
any further long term effect of HRT in other group of menopausal women willbe followed.
Key words : Hormonal replacement therapy, Bone changes.
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Parkin DM, Clayton D, Black RI, Masuyer E, Friedl [IP, lvanov E, et al. Chidhood leukaemia
in Europe after Chernobyl : b year follow-up. Br J Cancer 1996 ; zB : 1006-12.
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Cdncer in Sootfr"nfrica (editoriul). S Afr Med J rgsa ; 84 : lb.
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Enzensberger W, Fischer PA. Metonome in Parkinson' s disease (t"tt"|. l-anc€t 1996 ; g4? i Lg:l.
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Ringsven MK, Bond D. Gerontology and leadership skills for nurses. 2'd ed. Albany (NY)Delmar Publishers ; 1996.
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