Supplementary Information

Therapeutic potential of selanyl amide derivatives in the in vitro anticholinesterase

activity and in in vivo anti-amnesic action

Ethel A. Wilhelma, Marina Laura C. P. Torresa, Caroline Ferreira Pereiraa, Ane Gabriela

Vogta, Rodrigo Cervob, Brenda G. T. dos Santosb, Roberta Cargneluttib* and Cristiane

Luchesea*

a Programa de Pós-graduação em Bioquímica e Bioprospecção, Laboratório de Pesquisa

em Farmacologia Bioquímica (LaFarBio), Grupo de Pesquisa em Neurobiotecnologia

(GPN), Centro de Ciências Químicas, Farmacêuticas e de Alimentos, Universidade

Federal de Pelotas (UFPel), CEP 96010-900 Pelotas, RS, Brazil.b Department of Chemistry, Universidade Federal de Santa Maria, LMI – Laboratório de

Materiais Inorgânicos, 97105-900, Santa Maria, RS, Brazil.

Table of contents

NMR spectra of compounds 1-5 ………………………………………….………S1-S14

ESI+ MS spectra of compounds 1 and 2 ……...…………………………………S15-S16

FT-IR spectra of compounds 1 and 2 ……………………………………………S17-S18

1

2

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5

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Figure S1. 1H-NMR spectrum of (1) in CDCl3.

2

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Figure S2. 13C-NMR spectrum of (1) in CDCl3.

Figure S3. 77Se-NMR spectrum of (1) in CDCl3.

3

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Figure S4. 1H-NMR spectrum of (2) in CDCl3.

Figure S5. 13C-NMR spectrum of (2) in CDCl3.

4

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Figure S6. 77Se-NMR spectrum of (2) in CDCl3

Figure S7. 1H-NMR spectrum of (3) in CDCl3.

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Figure S8. 13C-NMR spectrum of (3) in CDCl3.

Figure S9. 1H-NMR spectrum of (4) in CDCl3.

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Figure S10. 13C-NMR spectrum of (4) in CDCl3.

Figure S11. 77Se-NMR spectrum of (4) in CDCl3.

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Figure S12. 1H-NMR spectrum of (5) in CDCl3.

Figure S13. 13C-NMR spectrum of (5) in CDCl3.

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Figure S14. 77Se-NMR spectrum of (5) in CDCl3.

.

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Figure S15. ESI+ MS spectrum of compound (1).

Figure S16. ESI+ MS spectrum of compound (2).

Figure S17. FT-IR spectrum of compound (1).

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7071

727374

Figure S18. FT-IR spectrum of compound (2).

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7576

77