Diabetes melitus. Curcumina diminui resistência periférica à insulina no

tecido muscular

25/08/10

A curcumina diminui a glicemia, o colesterol e os triglicérides e facilita o emagrecimento de diabéticos. Agora foi provado que elaaumenta a sensibilidade periférica à insulina, o que facilita a entrada de glicose nas células.

Curcumin improves insulin resistance in skeletal muscle of rats.

Na LX, Zhang YL, Li Y, Liu LY, Li R, Kong T, Sun CH. Nutr Metab Cardiovasc Dis. 2010 Mar 12.Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, Harbin 150086, PR China.

Abstract

BACKGROUND AND AIMS: Curcumin has been reported to lower plasma lipids and glucose in diabetic rats, and to decrease body weightin obese rats, which may partly be due to increased fatty acid oxidation and utilization in skeletal muscle. METHODS AND RESULTS:Diabetic rats induced by high-fat diet plus streptozotocin (STZ, 30mg/kg BW) were fed a diet containing 50, 150, or 250mg/kg BWcurcumin for 7 wk. Curcumin dose-dependently decreased plasma lipids and glucose and the dose 150mg/kg BW appeared to beadequate to produce a significant effect. Curcumin supplementation reduced glucose and insulin tolerance measured as areas under thecurve. L6 myotubes were treated with palmitate (0.25mmol/L) in the presence of different levels of curcumin for 24 h in our in vitroexperiment. Curcumin at 10mumol/L was adequate to cause a significant increase in 2-deoxy-[(3)H]d-glucose uptake by L6 myotubes.Curcumin up-regulated expression of phosphorylated AMP-activated protein kinase (AMPK), CD36, and carnitine palmitoyltransferase 1, but down-regulated expression of pyruvate dehydrogenase 4 and phosphorylated glycogen synthase (GS) inboth in vivo and in vitro studies. Moreover, curcumin increased phosphorylated acetyl COA carboxylase in L6 myotubes. The effectsof curcumin on these enzymes except for GS were suppressed by AMPK inhibitor, Compound C. LKB1, an upstream kinase of AMPK,was activated by curcumin and inhibited by radicicol, an LKB1 destabilizer. CONCLUSION: Curcumin improves muscular insulinresistance by increasing oxidation of fatty acid and glucose, which is, at least in part, mediated through LKB1-AMPK pathway.PMID: 20227862

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