FisioSangCap10_GRUPOS_SANGUINEOS

7/29/2019 FisioSangCap10_GRUPOS_SANGUINEOS

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Captulo 10

GRUPOS SANGUNEOS

Introduo

A membrana celular de todas as clulas tem antignios glicoproteicos especficos para

cada indivduo.

No caso dos eritrcitos estes antignios chamam-se aglutinognios e provocam a

aglutinao de eritrcitos quando em contacto com sangue tendo aglutinognios

diferentes, podendo causar acidentes fatais numa transfuso.

No homem h pelo menos 30 aglutinognios.

Os AB0 e Rh so os mais importantes.

Grupo ABO

So antignios geneticamente codificados que se encontram na membrana celular.H quatro antignios diferentes definindo quatro subgruposA, B, AB e 0.

No soro h anticorpos do grupo oposto (Quadro 10.I).

Quadro 10.I

Grupos sanguneos

Grupo Eritrcito Soro

A A b

B B a

AB A e B -

0 - a e b

http://en.wikipedia.org/wiki/Blood_typeFig. 10.1Grupos ABO
http://en.wikipedia.org/wiki/Blood_typehttp://en.wikipedia.org/wiki/Blood_typehttp://en.wikipedia.org/wiki/Blood_type


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Uma reaco entre dois grupos diferentes produz aglutinao quando fora do corpo e

hemolise quando dentro.

Os antignios A e B so formados pelo acrscimo ao antignio O de acetilglicosamina

ou galactose respectivamente.

Human red blood cells before (left) and after (right) adding serum containing anti-A antibodies. The

agglutination reaction reveals the presence of the A antigen on the surface of the cells.

Human red blood cells before (left) and after (right) adding serum containing anti-A antibodies. The

agglutination reaction reveals the presence of the A antigen on the surface of the cells.

http://en.wikipedia.org/wiki/Blood_type

Fig. 10.2Composio dos grupos sanguneos

http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/B/BloodGroups.html

Fig. 10.3

Pesquisa dos grupos sanguneos
http://en.wikipedia.org/wiki/Blood_typehttp://en.wikipedia.org/wiki/Blood_typehttp://users.rcn.com/jkimball.ma.ultranet/BiologyPages/B/BloodGroups.htmlhttp://users.rcn.com/jkimball.ma.ultranet/BiologyPages/B/BloodGroups.htmlhttp://users.rcn.com/jkimball.ma.ultranet/BiologyPages/B/BloodGroups.htmlhttp://en.wikipedia.org/wiki/Blood_type


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Gentica dos grupos sanguneos

A and B arecodominant, giving the ABphenotype.

Blood group inheritance

Mother/Father O A B AB

O O O, A O, B A, B

A O, A O, A O, A, B, AB A, B, AB

B O, B O, A, B, AB O, B A, B, AB

AB A, B A, B, AB A, B

Fig. 10.4 - Herana dos grupos sanguneos
http://en.wikipedia.org/wiki/Dominance_relationship#Codominancehttp://en.wikipedia.org/wiki/Dominance_relationship#Codominancehttp://en.wikipedia.org/wiki/Dominance_relationship#Codominancehttp://en.wikipedia.org/wiki/Phenotypehttp://en.wikipedia.org/wiki/Phenotypehttp://en.wikipedia.org/wiki/Phenotypehttp://en.wikipedia.org/wiki/Phenotypehttp://en.wikipedia.org/wiki/Dominance_relationship#Codominance


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Grupos sanguneos raros

ISBTN

Commonname abbreviation

Epitopeor carrier, notes Locus

001 ABO ABO

Carbohydrate (N-

Acetylgalactosamine,

galactose). A, B and H antigens

mainly elicitIgMantibody

reactions, although anti-H is

very rare, see theHh antigen

system(Bombay phenotype,

ISBT #18).

9

002 MNS MNS

GPA / GPB (glycophorinsA

and B). Main antigens M, N, S,

s.

4

003 P P1 Glycolipid. 22

004 Rhesus RH

Protein. C, c, D, E, e antigens

(there is no "d" antigen;lowercase "d" indicates the

absence of D).

1

005 Lutheran LU

Protein (member of the

immunoglobulin superfamily).

Set of 21 antigens.

19

006 Kell KEL

Glycoprotein. K1 can cause

hemolytic disease of the

newborn (anti-Kell), which can

be severe.

7

007 Lewis LE

Carbohydrate (fucoseresidue).

Main antigens Lea and Leb -

associated with tissue ABH

antigen secretion.

19
http://en.wikipedia.org/wiki/International_Society_of_Blood_Transfusionhttp://en.wikipedia.org/wiki/International_Society_of_Blood_Transfusionhttp://en.wikipedia.org/wiki/Epitopehttp://en.wikipedia.org/wiki/Epitopehttp://en.wikipedia.org/wiki/ABO_blood_group_systemhttp://en.wikipedia.org/wiki/ABO_blood_group_systemhttp://en.wikipedia.org/wiki/N-Acetylgalactosaminehttp://en.wikipedia.org/wiki/N-Acetylgalactosaminehttp://en.wikipedia.org/wiki/N-Acetylgalactosaminehttp://en.wikipedia.org/wiki/N-Acetylgalactosaminehttp://en.wikipedia.org/wiki/Galactosehttp://en.wikipedia.org/wiki/Galactosehttp://en.wikipedia.org/wiki/IgMhttp://en.wikipedia.org/wiki/IgMhttp://en.wikipedia.org/wiki/IgMhttp://en.wikipedia.org/wiki/Hh_antigen_systemhttp://en.wikipedia.org/wiki/Hh_antigen_systemhttp://en.wikipedia.org/wiki/Hh_antigen_systemhttp://en.wikipedia.org/wiki/Hh_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_9http://en.wikipedia.org/wiki/Chromosome_9http://en.wikipedia.org/wiki/MNS_antigen_systemhttp://en.wikipedia.org/wiki/MNS_antigen_systemhttp://en.wikipedia.org/wiki/Glycophorinhttp://en.wikipedia.org/wiki/Glycophorinhttp://en.wikipedia.org/wiki/Glycophorinhttp://en.wikipedia.org/wiki/Chromosome_4http://en.wikipedia.org/wiki/Chromosome_4http://en.wikipedia.org/wiki/P_antigen_systemhttp://en.wikipedia.org/wiki/P_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_22http://en.wikipedia.org/wiki/Chromosome_22http://en.wikipedia.org/wiki/Rhesus_blood_group_systemhttp://en.wikipedia.org/wiki/Rhesus_blood_group_systemhttp://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/Lutheran_antigen_systemhttp://en.wikipedia.org/wiki/Lutheran_antigen_systemhttp://en.wikipedia.org/wiki/Immunoglobulin_superfamilyhttp://en.wikipedia.org/wiki/Immunoglobulin_superfamilyhttp://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Kell_antigen_systemhttp://en.wikipedia.org/wiki/Kell_antigen_systemhttp://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn_(anti-Kell)http://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn_(anti-Kell)http://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn_(anti-Kell)http://en.wikipedia.org/wiki/Chromosome_7http://en.wikipedia.org/wiki/Chromosome_7http://en.wikipedia.org/wiki/Lewis_antigen_systemhttp://en.wikipedia.org/wiki/Lewis_antigen_systemhttp://en.wikipedia.org/wiki/Fucosehttp://en.wikipedia.org/wiki/Fucosehttp://en.wikipedia.org/wiki/Fucosehttp://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Fucosehttp://en.wikipedia.org/wiki/Lewis_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_7http://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn_(anti-Kell)http://en.wikipedia.org/wiki/Hemolytic_disease_of_the_newborn_(anti-Kell)http://en.wikipedia.org/wiki/Kell_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Immunoglobulin_superfamilyhttp://en.wikipedia.org/wiki/Lutheran_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/Rhesus_blood_group_systemhttp://en.wikipedia.org/wiki/Chromosome_22http://en.wikipedia.org/wiki/P_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_4http://en.wikipedia.org/wiki/Glycophorinhttp://en.wikipedia.org/wiki/MNS_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_9http://en.wikipedia.org/wiki/Hh_antigen_systemhttp://en.wikipedia.org/wiki/Hh_antigen_systemhttp://en.wikipedia.org/wiki/IgMhttp://en.wikipedia.org/wiki/Galactosehttp://en.wikipedia.org/wiki/N-Acetylgalactosaminehttp://en.wikipedia.org/wiki/N-Acetylgalactosaminehttp://en.wikipedia.org/wiki/ABO_blood_group_systemhttp://en.wikipedia.org/wiki/Epitopehttp://en.wikipedia.org/wiki/International_Society_of_Blood_Transfusion


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008 Duffy FY

Protein (chemokine receptor).

Main antigens Fya and Fyb.

Individuals lacking Duffy

antigens altogether are immune

tomalariacaused byPlasmodium vivaxand

Plasmodium knowlesi.

1

009 Kidd JKProtein (urea transporter). Main

antigens Jka and Jkb.18

010 Diego DI

Glycoprotein (band 3, AE 1, or

anion exchange). Positive blood

is found only amongEast

AsiansandNative Americans.

17

011Yt or

CartwrightYT

Protein (AChE,

acetylcholinesterase).7

012 XG XG Glycoprotein. X

013 Scianna SC Glycoprotein. 1

014 Dombrock DO

Glycoprotein (fixed to cell

membrane by GPI, orglycosyl-

phosphatidyl-inositol).

12

015 Colton COAquaporin 1. Main antigens

Co(a) and Co(b).7

016Landsteiner-

WienerLW

Protein (member of the

immunoglobulin superfamily).19

017 Chido/Rodgers CH/RGC4A C4B (complement

fractions).6

018 Hh/Bombay H Carbohydrate (fucoseresidue). 19
http://en.wikipedia.org/wiki/Duffy_antigenhttp://en.wikipedia.org/wiki/Duffy_antigenhttp://en.wikipedia.org/wiki/Chemokine_receptorhttp://en.wikipedia.org/wiki/Chemokine_receptorhttp://en.wikipedia.org/wiki/Chemokine_receptorhttp://en.wikipedia.org/wiki/Malariahttp://en.wikipedia.org/wiki/Malariahttp://en.wikipedia.org/wiki/Malariahttp://en.wikipedia.org/wiki/Plasmodium_vivaxhttp://en.wikipedia.org/wiki/Plasmodium_vivaxhttp://en.wikipedia.org/wiki/Plasmodium_knowlesihttp://en.wikipedia.org/wiki/Plasmodium_knowlesihttp://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/Kidd_antigen_systemhttp://en.wikipedia.org/wiki/Kidd_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_18http://en.wikipedia.org/wiki/Chromosome_18http://en.wikipedia.org/wiki/Diego_antigen_systemhttp://en.wikipedia.org/wiki/Diego_antigen_systemhttp://en.wikipedia.org/wiki/Band_3http://en.wikipedia.org/wiki/Band_3http://en.wikipedia.org/wiki/Band_3http://en.wikipedia.org/wiki/East_Asiahttp://en.wikipedia.org/wiki/East_Asiahttp://en.wikipedia.org/wiki/East_Asiahttp://en.wikipedia.org/wiki/East_Asiahttp://en.wikipedia.org/wiki/Indigenous_peoples_of_the_Americashttp://en.wikipedia.org/wiki/Indigenous_peoples_of_the_Americashttp://en.wikipedia.org/wiki/Indigenous_peoples_of_the_Americashttp://en.wikipedia.org/wiki/Chromosome_17http://en.wikipedia.org/wiki/Chromosome_17http://en.wikipedia.org/wiki/Yt_antigen_systemhttp://en.wikipedia.org/wiki/Yt_antigen_systemhttp://en.wikipedia.org/wiki/Yt_antigen_systemhttp://en.wikipedia.org/wiki/Acetylcholinesterasehttp://en.wikipedia.org/wiki/Acetylcholinesterasehttp://en.wikipedia.org/wiki/Chromosome_7http://en.wikipedia.org/wiki/Chromosome_7http://en.wikipedia.org/wiki/XG_antigen_systemhttp://en.wikipedia.org/wiki/XG_antigen_systemhttp://en.wikipedia.org/wiki/X_chromosomehttp://en.wikipedia.org/wiki/X_chromosomehttp://en.wikipedia.org/wiki/Scianna_antigen_systemhttp://en.wikipedia.org/wiki/Scianna_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/Dombrock_antigen_systemhttp://en.wikipedia.org/wiki/Dombrock_antigen_systemhttp://en.wikipedia.org/wiki/Glycosyl-phosphatidyl-inositolhttp://en.wikipedia.org/wiki/Glycosyl-phosphatidyl-inositolhttp://en.wikipedia.org/wiki/Glycosyl-phosphatidyl-inositolhttp://en.wikipedia.org/wiki/Glycosyl-phosphatidyl-inositolhttp://en.wikipedia.org/wiki/Chromosome_12http://en.wikipedia.org/wiki/Chromosome_12http://en.wikipedia.org/wiki/Colton_antigen_systemhttp://en.wikipedia.org/wiki/Colton_antigen_systemhttp://en.wikipedia.org/wiki/Aquaporin_1http://en.wikipedia.org/wiki/Aquaporin_1http://en.wikipedia.org/wiki/Chromosome_7http://en.wikipedia.org/wiki/Chromosome_7http://en.wikipedia.org/wiki/Landsteiner-Wiener_antigen_systemhttp://en.wikipedia.org/wiki/Landsteiner-Wiener_antigen_systemhttp://en.wikipedia.org/wiki/Landsteiner-Wiener_antigen_systemhttp://en.wikipedia.org/wiki/Immunoglobulin_superfamilyhttp://en.wikipedia.org/wiki/Immunoglobulin_superfamilyhttp://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Chido_antigen_systemhttp://en.wikipedia.org/wiki/Chido_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_6http://en.wikipedia.org/wiki/Chromosome_6http://en.wikipedia.org/wiki/Hh_antigen_systemhttp://en.wikipedia.org/wiki/Hh_antigen_systemhttp://en.wikipedia.org/wiki/Fucosehttp://en.wikipedia.org/wiki/Fucosehttp://en.wikipedia.org/wiki/Fucosehttp://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Fucosehttp://en.wikipedia.org/wiki/Hh_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_6http://en.wikipedia.org/wiki/Chido_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Immunoglobulin_superfamilyhttp://en.wikipedia.org/wiki/Landsteiner-Wiener_antigen_systemhttp://en.wikipedia.org/wiki/Landsteiner-Wiener_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_7http://en.wikipedia.org/wiki/Aquaporin_1http://en.wikipedia.org/wiki/Colton_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_12http://en.wikipedia.org/wiki/Glycosyl-phosphatidyl-inositolhttp://en.wikipedia.org/wiki/Glycosyl-phosphatidyl-inositolhttp://en.wikipedia.org/wiki/Dombrock_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/Scianna_antigen_systemhttp://en.wikipedia.org/wiki/X_chromosomehttp://en.wikipedia.org/wiki/XG_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_7http://en.wikipedia.org/wiki/Acetylcholinesterasehttp://en.wikipedia.org/wiki/Yt_antigen_systemhttp://en.wikipedia.org/wiki/Yt_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_17http://en.wikipedia.org/wiki/Indigenous_peoples_of_the_Americashttp://en.wikipedia.org/wiki/East_Asiahttp://en.wikipedia.org/wiki/East_Asiahttp://en.wikipedia.org/wiki/Band_3http://en.wikipedia.org/wiki/Diego_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_18http://en.wikipedia.org/wiki/Kidd_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/Plasmodium_knowlesihttp://en.wikipedia.org/wiki/Plasmodium_vivaxhttp://en.wikipedia.org/wiki/Malariahttp://en.wikipedia.org/wiki/Chemokine_receptorhttp://en.wikipedia.org/wiki/Duffy_antigen


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019 Kx XK Glycoprotein. X

020 Gerbich GE

GPC / GPD (GlycophorinsC

and D). 2

021 Cromer CROM

Glycoprotein (DAF orCD55,

regulates complement fractions

C3 and C5, attached to the

membrane by GPI).

1

022 Knops KNGlycoprotein (CR1 orCD35,

immune complex receptor).

1

023 Indian INGlycoprotein (CD44adhesion

function?).11

024 Ok OK Glycoprotein (CD147). 19

025 Raph MER2 Transmembrane glycoprotein. 11

026 JMH JMHProtein (fixed to cell membrane

by GPI).6

027 Ii IBranched (I) / unbranched (i)

polysaccharide.6

028 Globoside P Glycolipid. 3

029 GIL GIL Aquaporin 3. 9

http://en.wikipedia.org/wiki/Blood_groups
http://en.wikipedia.org/wiki/XK_(protein)http://en.wikipedia.org/wiki/XK_(protein)http://en.wikipedia.org/wiki/X_chromosomehttp://en.wikipedia.org/wiki/X_chromosomehttp://en.wikipedia.org/wiki/Gerbich_antigen_systemhttp://en.wikipedia.org/wiki/Gerbich_antigen_systemhttp://en.wikipedia.org/wiki/Glycophorinhttp://en.wikipedia.org/wiki/Glycophorinhttp://en.wikipedia.org/wiki/Glycophorinhttp://en.wikipedia.org/wiki/Chromosome_2http://en.wikipedia.org/wiki/Chromosome_2http://en.wikipedia.org/wiki/Cromer_antigen_systemhttp://en.wikipedia.org/wiki/Cromer_antigen_systemhttp://en.wikipedia.org/wiki/CD55http://en.wikipedia.org/wiki/CD55http://en.wikipedia.org/wiki/CD55http://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/Knops_antigen_systemhttp://en.wikipedia.org/wiki/Knops_antigen_systemhttp://en.wikipedia.org/wiki/CD35http://en.wikipedia.org/wiki/CD35http://en.wikipedia.org/wiki/CD35http://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/Indian_antigen_systemhttp://en.wikipedia.org/wiki/Indian_antigen_systemhttp://en.wikipedia.org/wiki/CD44http://en.wikipedia.org/wiki/CD44http://en.wikipedia.org/wiki/CD44http://en.wikipedia.org/wiki/Chromosome_11http://en.wikipedia.org/wiki/Chromosome_11http://en.wikipedia.org/w/index.php?title=Ok_antigen_system&action=edit&redlink=1http://en.wikipedia.org/w/index.php?title=Ok_antigen_system&action=edit&redlink=1http://en.wikipedia.org/wiki/CD147http://en.wikipedia.org/wiki/CD147http://en.wikipedia.org/wiki/CD147http://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/Raph_antigen_systemhttp://en.wikipedia.org/wiki/Raph_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_11http://en.wikipedia.org/wiki/Chromosome_11http://en.wikipedia.org/wiki/JMH_antigen_systemhttp://en.wikipedia.org/wiki/JMH_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_6http://en.wikipedia.org/wiki/Chromosome_6http://en.wikipedia.org/wiki/Ii_antigen_systemhttp://en.wikipedia.org/wiki/Ii_antigen_systemhttp://en.wikipedia.org/wiki/Polysaccharidehttp://en.wikipedia.org/wiki/Polysaccharidehttp://en.wikipedia.org/wiki/Chromosome_6http://en.wikipedia.org/wiki/Chromosome_6http://en.wikipedia.org/w/index.php?title=Globoside_antigen_system&action=edit&redlink=1http://en.wikipedia.org/w/index.php?title=Globoside_antigen_system&action=edit&redlink=1http://en.wikipedia.org/wiki/Glycolipidhttp://en.wikipedia.org/wiki/Glycolipidhttp://en.wikipedia.org/wiki/Chromosome_3http://en.wikipedia.org/wiki/Chromosome_3http://en.wikipedia.org/wiki/GIL_antigen_systemhttp://en.wikipedia.org/wiki/GIL_antigen_systemhttp://en.wikipedia.org/wiki/Aquaporin_3http://en.wikipedia.org/wiki/Aquaporin_3http://en.wikipedia.org/wiki/Chromosome_9http://en.wikipedia.org/wiki/Chromosome_9http://en.wikipedia.org/wiki/Blood_groupshttp://en.wikipedia.org/wiki/Blood_groupshttp://en.wikipedia.org/wiki/Blood_groupshttp://en.wikipedia.org/wiki/Chromosome_9http://en.wikipedia.org/wiki/Aquaporin_3http://en.wikipedia.org/wiki/GIL_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_3http://en.wikipedia.org/wiki/Glycolipidhttp://en.wikipedia.org/w/index.php?title=Globoside_antigen_system&action=edit&redlink=1http://en.wikipedia.org/wiki/Chromosome_6http://en.wikipedia.org/wiki/Polysaccharidehttp://en.wikipedia.org/wiki/Ii_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_6http://en.wikipedia.org/wiki/JMH_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_11http://en.wikipedia.org/wiki/Raph_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_19http://en.wikipedia.org/wiki/CD147http://en.wikipedia.org/w/index.php?title=Ok_antigen_system&action=edit&redlink=1http://en.wikipedia.org/wiki/Chromosome_11http://en.wikipedia.org/wiki/CD44http://en.wikipedia.org/wiki/Indian_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/CD35http://en.wikipedia.org/wiki/Knops_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_1http://en.wikipedia.org/wiki/CD55http://en.wikipedia.org/wiki/Cromer_antigen_systemhttp://en.wikipedia.org/wiki/Chromosome_2http://en.wikipedia.org/wiki/Glycophorinhttp://en.wikipedia.org/wiki/Gerbich_antigen_systemhttp://en.wikipedia.org/wiki/X_chromosomehttp://en.wikipedia.org/wiki/XK_(protein)


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Sistema Rh

Protenas transmembranarias com ansas expostas superfcie.

So usadas para transportar anidrido carbnico e ou amnia atravs da membrana.

H vrios tipos de antignios Rh.

As clulas Rh positivas designam-se por D.15% da populao no tem antignio D e por isso diz-se Rh negativa.

Genetica do Rh

Parents' Rh types Possible allele combinations Possible Rh in the children

Both + ++ & ++ ++ Positive

Both + ++ & +- ++ or +- Positive

Both + +- & +- ++ or +- or --poitive ornegative

Both - -- & -- -- Negative

One + & One - ++ & -- +- Positive

One + & One - +- & -- +- or --poitive ornegative

http://www.paternityangel.com/Articles_zone/Blood/BloodType3.htm

Genotipos Rh

Rhesus genotypes

Genotype Symbol Rh(D) status

cde/cde Rr Negative

CDe/cde R1r Positive

CDe/CDe R1R1 Positive

cDE/cde R2r Positive

CDe/cDE R1R2 Positive

cDE/Cde R2R2 Positive
http://www.paternityangel.com/Articles_zone/Blood/BloodType3.htmhttp://www.paternityangel.com/Articles_zone/Blood/BloodType3.htmhttp://www.paternityangel.com/Articles_zone/Blood/BloodType3.htm


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Incompatibilidade me-feto

O maior problema em sade a incompatibilidade me-feto.

Se a me Rh-negativa e o filho positivo (herana paterna) a me pode criar anticorposanti-Rh que num prximo filho poder originar uma reaco antignio-anticorpo

provocando a destruio quase total dos eritrcitos do filho, resultando a doena

hemoltica do recm-nascido ou eritroblastose fetal, doena grave que pode ser mortal.

http://www.nlm.nih.gov/medlineplus/ency/presentations/100217_1.htm

http://www.nlm.nih.gov/medlineplus/ency/imagepages/9069.htm

Fig. 10.5Incompatibilidade me-feto

Antes tratava-se com a exsanguineo transfuso transfuso total de sangue.

Actualmente trata-se com a injeco em cada gravidez e 72 horas aps o nascimento da

imunoglobulina Rh (RhIg) ou Rhogam.
http://www.nlm.nih.gov/medlineplus/ency/presentations/100217_1.htmhttp://www.nlm.nih.gov/medlineplus/ency/presentations/100217_1.htmhttp://www.nlm.nih.gov/medlineplus/ency/imagepages/9069.htmhttp://www.nlm.nih.gov/medlineplus/ency/imagepages/9069.htmhttp://www.nlm.nih.gov/medlineplus/ency/imagepages/9069.htmhttp://www.nlm.nih.gov/medlineplus/ency/presentations/100217_1.htm

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FisioSangCap10_GRUPOS_SANGUINEOS