Eliminação de Hofmann (1818 -1892)

produto principal(94%)

CH3CH2CH2CH CH2CH3CH2CH CHCH3CH3CH2CH2 CH

N

CH3

H3C

CH3

CH3

N

CH3

H3C CH3

CH3CH2CH2 CH

OH2+

CH3 CH3CH2CH CHCH3 CH3CH2CH2CH CH2

produto principalH2O

Eliminação de água em álcoois

Eliminação de aminas

Menos impedido

Produto Zaitsev

Produto Hofmann

CH3CH CH2NCH2CH2CH3

CH3

CH3

CH3

CH3CH CH2N:

CH3

CH3

CH3

CH2 CHCH3

1H 2H

CH3CH CH2NCH2CH2CH3

CH3

CH3

CH3

CH3CH CH2N:

CH3

CH3

CH3

CH2 CHCH3

1H 2H

1. CH3I (exc)

2. Ag2O, H2O, calor

NH

1) CH3I exc

2) Ag2O, aquecimento ?

Curare /kjuːˈrɑːriː/[1] is a common name for various arrow

poisons originating from South America. The three main types of curare are:

Tubocurare (also known as tube or bamboo curare, because of its packing into hollow bamboo tubes; main toxin is D-tubocurarine). It is a mono-quaternary alkaloid, an isoquinoline derivative.

Calebas curare (also called "gourd curare" by older Britishclassifications, being packed into hollow gourds; main toxins are alloferine and toxiferine)

Pot curare (packed in terra cotta pots; main toxins are protocurarine, protocurine, and protocuridine).

alloferine

Strychnus toxifera

Tubocurarine chloride is an alkaloid of the benzylisoquinoline type. It is an antagonist of nicotinic neuromuscular acetylcholine receptors that is used to paralyse patients undergoing anaesthesia.

Chondrodendron tomentosum

Tubocurarine chloride

Atracurium besylate injection is indicated, as an adjunct to generalanesthesia, to facilitate endotracheal intubation and to provide skeletalmuscle relaxation during surgery or mechanical ventilation.

The pH is adjusted to 3.25 to 3.65 with benzenesulfonic acid.

Atracurium besylate

Quais seriam os produtos da eliminação de Hofmann quando obesilato de atracurium é tratado em meio alcalino?